The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin

Stable Identifier
R-HSA-68950
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
At the beginning of this reaction, 1 molecule of 'dTTP', 1 molecule of 'dGTP', 1 molecule of 'dATP', 1 molecule of 'RNA primer:origin duplex:DNA polymerase alpha:primase complex', and 1 molecule of 'dCTP' are present. At the end of this reaction, 1 molecule of 'RNA primer-DNA primer:origin duplex' is present.

This reaction takes place in the 'nucleus' and is mediated by the 'DNA-directed DNA polymerase activity' of 'DNA polymerase alpha:primase'.
Literature References
PubMed ID Title Journal Year
6094569 Purification of a DNA polymerase-DNA primase complex from calf thymus glands

Rafter, E, Bollum, FJ, Chang, LM, Augl, C

J. Biol. Chem. 1984
Participants
Input
Output
Participates
as an event of
Catalyst Activity

DNA-directed DNA polymerase activity of DNA polymerase alpha:primase [nucleoplasm]

Physical Entity
DNA polymerase alpha:primase [nucleoplasm] (Homo sapiens)
Activity
DNA-directed DNA polymerase activity (GO:0003887)
Orthologous Events
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Bos taurus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Caenorhabditis elegans)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Canis familiaris)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Dictyostelium discoideum)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Drosophila melanogaster)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Gallus gallus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Mus musculus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Plasmodium falciparum)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Rattus norvegicus)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Saccharomyces cerevisiae)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Schizosaccharomyces pombe)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin (Sus scrofa)
Cite Us!