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DNA replication initiation
Stable Identifier
R-HSA-68952
DOI
10.3180/REACT_2244.1
Type
Pathway
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
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Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA replication initiation (Homo sapiens)
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DNA polymerases are not capable of de novo DNA synthesis and require synthesis of a primer, usually by a DNA-dependent RNA polymerase (primase) to begin DNA synthesis. In eukaryotic cells, the primer is synthesized by DNA polymerase alpha:primase. First, the DNA primase portion of this complex synthesizes approximately 6-10 nucleotides of RNA primer and then the DNA polymerase portion synthesizes an additional 20 nucleotides of DNA (Frick & Richardson 2002; Wang et al 1984).
Literature References
PubMed ID
Title
Journal
Year
11395402
DNA primases.
Frick, DN
,
Richardson, CC
Annu Rev Biochem
2002
6693436
DNA primase from KB cells. Characterization of a primase activity tightly associated with immunoaffinity-purified DNA polymerase-alpha.
Hu, SZ
,
Korn, D
,
Wang, TS
J Biol Chem
1984
Participants
Events
The primase component of DNA polymerase:primase synthesizes a 6-10 nucleotide RNA primer at the origin
(Homo sapiens)
The polymerase component of DNA polymerase alpha:primase synthesizes a 20-nucleotide primer at the origin
(Homo sapiens)
Participates
as an event of
Synthesis of DNA (Homo sapiens)
Event Information
Go Biological Process
DNA replication initiation (0006270)
Orthologous Events
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DNA replication initiation (Gallus gallus)
DNA replication initiation (Mus musculus)
DNA replication initiation (Plasmodium falciparum)
DNA replication initiation (Rattus norvegicus)
DNA replication initiation (Saccharomyces cerevisiae)
DNA replication initiation (Schizosaccharomyces pombe)
DNA replication initiation (Sus scrofa)
Created
O'Donnell, M (2003-06-05)
Davey, MJ (2003-06-05)
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