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RPA binds to the Flap
Stable Identifier
R-HSA-69140
Type
Reaction [binding]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Cell Cycle (Homo sapiens)
Cell Cycle, Mitotic (Homo sapiens)
S Phase (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
RPA binds to the Flap (Homo sapiens)
DNA Replication (Homo sapiens)
Synthesis of DNA (Homo sapiens)
DNA strand elongation (Homo sapiens)
Lagging Strand Synthesis (Homo sapiens)
Processive synthesis on the lagging strand (Homo sapiens)
Removal of the Flap Intermediate (Homo sapiens)
RPA binds to the Flap (Homo sapiens)
General
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
The first step in the removal of the flap intermediate is the binding of Replication Protein A (RPA) to the long flap structure. RPA is a eukaryotic single-stranded DNA binding protein.
Literature References
PubMed ID
Title
Journal
Year
11473323
RPA governs endonuclease switching during processing of Okazaki fragments in eukaryotes.
Seo, YS
,
Bae, SH
,
Bae, KH
,
Kim, JA
Nature
2001
Participants
Input
Processive complex:Okazaki fragment:Flap [nucleoplasm]
(Homo sapiens)
RPA heterotrimer [nucleoplasm]
(Homo sapiens)
Output
Processive complex:Okazaki fragment:Flap:RPA heterotrimer [nucleoplasm]
(Homo sapiens)
Participates
as an event of
Removal of the Flap Intermediate (Homo sapiens)
Orthologous Events
RPA binds to the Flap (Bos taurus)
RPA binds to the Flap (Canis familiaris)
RPA binds to the Flap (Drosophila melanogaster)
RPA binds to the Flap (Mus musculus)
RPA binds to the Flap (Plasmodium falciparum)
RPA binds to the Flap (Rattus norvegicus)
RPA binds to the Flap (Schizosaccharomyces pombe)
RPA binds to the Flap (Sus scrofa)
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