WEE1 phosphorylates CDK2, inhibiting entry into S-phase (Watanabe et al., 1995; Wu et al., 2001). WEE1-mediated phosphorylation of CDK2 is enhanced in the presence of CABLES1, which can form a complex with CDK2 bound to cyclin E (CCNE) or cyclin A (CCNA) (Wu et al. 2001).
Broome, M, Hunter, T, Watanabe, N
Chung, DC, Zukerberg, LR, Xiao, H, Chuang, Y, Wu, CL, Kirley, SD
protein tyrosine kinase activity of WEE1 [nucleoplasm]
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