Reactome | Phosphorylation of Cyclin E:CDK2 complexes by WEE1

Phosphorylation of Cyclin E:CDK2 complexes by WEE1

Stable Identifier

R-HSA-69195

Type

Reaction [transition]

Species

Homo sapiens

Compartment

nucleoplasm

ReviewStatus

5/5

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Phosphorylation of Cyclin E:CDK2 complexes by WEE1

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WEE1 phosphorylates CDK2, inhibiting entry into S-phase (Watanabe et al., 1995; Wu et al., 2001). WEE1-mediated phosphorylation of CDK2 is enhanced in the presence of CABLES1, which can form a complex with CDK2 bound to cyclin E (CCNE) or cyclin A (CCNA) (Wu et al. 2001).

Literature References

PubMed ID	Title	Journal	Year
7743995	Regulation of the human WEE1Hu CDK tyrosine 15-kinase during the cell cycle Broome, M, Hunter, T, Watanabe, N	EMBO J	1995
11585773	Cables enhances cdk2 tyrosine 15 phosphorylation by Wee1, inhibits cell growth, and is lost in many human colon and squamous cancers Chung, DC, Zukerberg, LR, Xiao, H, Chuang, Y, Wu, CL, Kirley, SD	Cancer Res	2001