Phosphorylation of Cdc25A at Ser-123 by Chk1

Stable Identifier
R-HSA-69604
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
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Phosphorylation of Cdc25A at Ser-123 by Chk1
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Detection of DNA damage caused by ionizing radiation results in the phosphorylation of Cdc25A at Ser-123 by Chk1, inhibiting Cdc25A.

Literature References
PubMed ID Title Journal Year
12399544 Disruption of the checkpoint kinase 1/cell division cycle 25A pathway abrogates ionizing radiation-induced S and G2 checkpoints.

Piwnica-Worms, H, Zhao, H, Watkins, JL

Proc Natl Acad Sci U S A 2002
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as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S317,S345-CHEK1 [nucleoplasm]

Physical Entity
p-S317,S345-CHEK1 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Caenorhabditis elegans)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Canis familiaris)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Danio rerio)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Drosophila melanogaster)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Mus musculus)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Rattus norvegicus)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Saccharomyces cerevisiae)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Schizosaccharomyces pombe)
Phosphorylation of Cdc25A at Ser-123 by Chk1 (Sus scrofa)
Created
Hoffmann, I  (2003-06-05)
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