Phosphorylation of Cdc25A at Ser-123 by Chk2

Stable Identifier
R-HSA-69608
Type
Reaction [transition]
Species
Homo sapiens
Compartment
nucleoplasm
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Phosphorylation of Cdc25A at Ser-123 by Chk2
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout

Detection of DNA damage caused by ionizing radiation results in the phosphorylation of Cdc25A at Ser-123 by Chk2 (Mailand et al. 2001).

Literature References
PubMed ID Title Journal Year
11298456 The ATM-Chk2-Cdc25A checkpoint pathway guards against radioresistant DNA synthesis.

Lukas, J, Syljuåsen, RG, Mailand, N

Nature 2001
Participants
Input
Output
Participates
as an event of
Catalyst Activity

protein serine/threonine kinase activity of p-S,3T-CHEK2 [nucleoplasm]

Physical Entity
p-S,3T-CHEK2 [nucleoplasm] (Homo sapiens)
Activity
protein serine/threonine kinase activity (GO:0004674)
Orthologous Events
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Bos taurus)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Caenorhabditis elegans)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Danio rerio)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Dictyostelium discoideum)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Drosophila melanogaster)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Gallus gallus)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Mus musculus)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Rattus norvegicus)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Saccharomyces cerevisiae)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Schizosaccharomyces pombe)
Phosphorylation of Cdc25A at Ser-123 by Chk2 (Sus scrofa)
Created
Hoffmann, I  (2003-06-05)
Cite Us!