Reactome | PDHB [mitochondrial matrix]

PDHB [mitochondrial matrix]

Stable Identifier

R-HSA-69967

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

pyruvate dehydrogenase E1 beta apoprotein, ODPA_HUMAN, Pyruvate dehydrogenase E1 component beta subunit, mitochondrial precursor , PDHE1-B

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P11177 PDHB

Gene Names

PDHB, PHE1B

Chain

transit peptide:1-30, chain:31-359

Reference Genes

BioGPS Gene:5162 PDHB

COSMIC (genes):PDHB PDHB

CTD Gene:5162 PDHB

dbSNP Gene:5162 PDHB

ENSEMBL:ENSG00000168291 PDHB

ENSEMBL_homo_sapiens_GENE:ENSG00000168291.13 PDHB

HGNC:8808 PDHB

KEGG Gene (Homo sapiens):5162 PDHB

Monarch:5162 PDHB

NCBI Gene:5162 PDHB

OMIM:179060 PDHB

UCSC:P11177 PDHB

Reference Transcript

Other Identifiers

11725620_a_at

16955511

208911_PM_s_at

208911_s_at

211023_PM_at

211023_at

2678368

2678369

2678370

2678371

2678372

2678374

2678375

2678378

2678379

2678380

2678381

2678382

2678383

2678385

39160_at

5162

8088384

A_33_P3364884

D90086_at

GE57444

GO:0003824

GO:0004739

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005759

GO:0005967

GO:0005975

GO:0006006

GO:0006086

GO:0006091

GO:0006099

GO:0006790

GO:0016491

GO:0034604

GO:0043226

GO:0045254

GO:0055086

GO:1901135

HMNXSV003005028

ILMN_1739274

PH_hs_0022756

TC03001499.hg

TC03002933.hg

g190791_3p_a_at

Participates

as a member of

as a component of

PDH E1 [mitochondrial matrix] (Homo sapiens)

Inferred To

pdhb [mitochondrial matrix] (Xenopus tropicalis)

Pdhb [mitochondrial matrix] (Drosophila melanogaster)

PDHB [mitochondrial matrix] (Bos taurus)

PDHB [mitochondrial matrix] (Caenorhabditis elegans)

PDHB [mitochondrial matrix] (Canis familiaris)

PDHB [mitochondrial matrix] (Dictyostelium discoideum)

PDHB [mitochondrial matrix] (Gallus gallus)

PDHB [mitochondrial matrix] (Mus musculus)

PDHB [mitochondrial matrix] (Rattus norvegicus)

PDHB [mitochondrial matrix] (Saccharomyces cerevisiae)

PDHB [mitochondrial matrix] (Schizosaccharomyces pombe)

PDHB [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_001166939.1, NP_001302465.1, NP_000916.2

OpenTargets

ENSG00000168291

GeneCards

P11177

HPA

ENSG00000168291-PDHB

Ensembl

ENST00000383714, ENSP00000373220, ENSG00000168291, ENSP00000417267, ENST00000302746, ENST00000485460, ENSP00000307241

PRO

P11177

Pharos - Targets

P11177

Orphanet

16632

HMDB Protein

HMDBP00012

PDB

3EXF, 3EXI, 3EXH, 3EXE, 6CFO, 3EXG, 6CER, 2OZL, 1NI4

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10515 DLAT	4	DLAT [mitochondrial matrix] (R-HSA-6792585) Lipo-K259-DLAT [mitochondrial matrix] (R-HSA-69969) LipoH2-K259-DLAT [mitochondrial matrix] (R-HSA-9861664) AcetyllipoH2-K132,K259-DLAT [mitochondrial matrix] (R-HSA-9861594)	0.558	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	6