Reactome | Lipo-K110-DLST [mitochondrial matrix]

Lipo-K110-DLST [mitochondrial matrix]

Stable Identifier

R-HSA-69993

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

alpha-ketoglutarate dehydrogenase E2, DLST, Dihydrolipoamide succinyltransferase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P36957 DLST

Gene Names

DLST, DLTS

Chain

transit peptide:1-67, chain:68-453

Reference Genes

BioGPS Gene:1743 DLST

COSMIC (genes):DLST DLST

CTD Gene:1743 DLST

dbSNP Gene:1743 DLST

ENSEMBL:ENSG00000119689 DLST

ENSEMBL:ENSG00000119689.15 DLST

HGNC:2911 DLST

KEGG Gene (Homo sapiens):1743 DLST

Monarch:1743 DLST

NCBI Gene:1743 DLST

OMIM:126063 DLST

UCSC:P36957 DLST

Reference Transcript

RefSeq:NM_001933.4 DLST

Other Identifiers

11720929_a_at

11720930_s_at

11720931_x_at

11720932_s_at

11748080_a_at

11751226_x_at

16786524

1743

215210_PM_s_at

215210_s_at

2418675

2418678

2418682

33257_at

33258_g_at

3544351

3544352

3544353

3544354

3544355

3544356

3544358

3544360

3544363

3544364

3544365

3544367

3544369

3544370

3544372

3544373

3544374

3544375

3544376

3544377

3544378

3544379

3544380

3544381

45545_at

7975747

A_14_P109426

A_24_P13572

D26535_s_at

GE61495

GO:0003824

GO:0004149

GO:0005515

GO:0005634

GO:0005654

GO:0005739

GO:0005759

GO:0005829

GO:0006091

GO:0006099

GO:0006103

GO:0006104

GO:0006520

GO:0006790

GO:0016020

GO:0016740

GO:0016746

GO:0033512

GO:0036211

GO:0043226

GO:0045252

GO:0055086

GO:0106077

GO:0140096

GO:1901135

GO:1990204

HMNXSV003018081

HMNXSV003048834

Hs.296348.0.S1_3p_s_at

ILMN_1773228

PH_hs_0029663

PH_hs_0032549

TC14000465.hg

TC14001772.hg

Participates

as a component of

lipo-aKGDH E2 [mitochondrial matrix] (Homo sapiens)

Other forms of this molecule

DLST [mitochondrial matrix]

Inferred To

KGD2 [mitochondrial matrix] (Saccharomyces cerevisiae)

odhB [mitochondrial matrix] (Dictyostelium discoideum)

dlst-1 [mitochondrial matrix] (Caenorhabditis elegans)

alpha-KGDHC [mitochondrial matrix] (Drosophila melanogaster)

DLST [mitochondrial matrix] (Bos taurus)

DLST [mitochondrial matrix] (Gallus gallus)

DLST [mitochondrial matrix] (Sus scrofa)

Dlst [mitochondrial matrix] (Mus musculus)

Dlst [mitochondrial matrix] (Rattus norvegicus)

kgd2 [mitochondrial matrix] (Schizosaccharomyces pombe)

Lipo-K110-DLST [mitochondrial matrix] (Canis familiaris)

Lipo-K110-DLST [mitochondrial matrix] (Danio rerio)

Lipo-K110-DLST [mitochondrial matrix] (Plasmodium falciparum)

dlst [mitochondrial matrix] (Xenopus tropicalis)

Modified Residues

Name

N6-lipoyl-L-lysine at 110

Coordinate

110

PsiMod Name

N6-lipoyl-L-lysine [MOD:00127]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine.

Cross References

RefSeq

NP_001924.2

OpenTargets

ENSG00000119689

IntEnz

2.3.1.61

GeneCards

P36957

HPA

ENSG00000119689-DLST

Ensembl

ENSP00000335304, ENSG00000119689, ENST00000334220

PRO

P36957

Pharos - Targets

P36957

PDB

6H05

HMDB Protein

HMDBP00939

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9ULW0 TPX2	2	TPX2 [cytosol] (R-HSA-8853407) TPX2 [nucleoplasm] (R-HSA-2564700)	0.556	3
UniProt:Q96P20 NLRP3	2	K63polyUb-NLRP3 [cytosol] (R-HSA-6783288) NLRP3 [cytosol] (R-HSA-561189)	0.556	3
UniProt:P07437 TUBB	3	TUBB [cytosol] (R-HSA-9020816) TUBB [azurophil granule lumen] (R-HSA-6799370) TUBB [extracellular region] (R-HSA-380317)	0.556	3
UniProt:Q10981 FUT2	1	FUT2 [Golgi membrane] (R-HSA-2980904)	0.556	3
UniProt:Q8N2W9 PIAS4	2	PIAS4 [nucleoplasm] (R-HSA-2993789) monoSUMO1-K35-PIAS4 [nucleoplasm] (R-HSA-3968415)	0.556	3
UniProt:Q7Z434 MAVS	2	MAVS [mitochondrial outer membrane] (R-HSA-913730) K48polyUb-MAVS [mitochondrial outer membrane] (R-HSA-983463)	0.556	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.556	3
UniProt:P16422 EPCAM	1	EPCAM [plasma membrane] (R-HSA-375068)	0.556	3
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3
UniProt:P61224 RAP1B	2	RAP1B [azurophil granule membrane] (R-HSA-6804972) RAP1B [plasma membrane] (R-HSA-377590)	0.556	3
UniProt:P26715 KLRC1	1	KLRC1 [plasma membrane] (R-HSA-3006545)	0.556	3
UniProt:P06493 CDK1	11	CDK1 [endoplasmic reticulum membrane] (R-HSA-264424) p-Y4-CDK1 [cytosol] (R-HSA-9836187) p-T14,T161-CDK1 [nucleoplasm] (R-HSA-170078) p-T14-CDK1 [nucleoplasm] (R-HSA-170045) p-T14-CDK1 [cytosol] (R-HSA-170064) CDK1 [nucleoplasm] (R-HSA-68889) CDK1 [cytosol] (R-HSA-170075) p-T14,Y15,T161-CDK1 [cytosol] (R-HSA-170071) p-T161-CDK1 [cytosol] (R-HSA-157415) p-T14,Y15,T161-CDK1 [nucleoplasm] (R-HSA-170074) p-T161-CDK1 [nucleoplasm] (R-HSA-170066)	0.499	3
UniProt:P62258 YWHAE	1	YWHAE [cytosol] (R-HSA-194368)	0.499	4

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