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Lipo-K110-DLST [mitochondrial matrix]
Stable Identifier
R-HSA-69993
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
alpha-ketoglutarate dehydrogenase E2, DLST, Dihydrolipoamide succinyltransferase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
OGDH complex synthesizes succinyl-CoA from 2-OG (Homo sapiens)
DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
DLST transfers succinyl to CoA (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
OGDH dimer decarboxylates 2-OG (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Glyoxylate metabolism and glycine degradation (Homo sapiens)
Glycine degradation (Homo sapiens)
DLD dimer:2xFAD oxidises GCSH:DHLL to GCSH:lipoate (Homo sapiens)
OGDH complex [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
Lysine catabolism (Homo sapiens)
OADH complex synthesizes glutaryl-CoA from 2-OA (Homo sapiens)
DHTKD1 dimer decarboxylates 2-OA (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
OADH complex [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
OADH complex [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
DLST transfers glutaryl to CoA (Homo sapiens)
OADH complex [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
Protein lipoylation (Homo sapiens)
LIPT1 transfers lipoyl group from lipoyl-GCSH to DBT/DLST (Homo sapiens)
Lipoylated DBT/DLST [mitochondrial matrix] (Homo sapiens)
Lipo-K110-DLST [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36957 DLST
Gene Names
DLST, DLTS
Chain
transit peptide:1-67, chain:68-453
Reference Genes
BioGPS Gene:1743 DLST
COSMIC (genes):DLST DLST
CTD Gene:1743 DLST
dbSNP Gene:1743 DLST
ENSEMBL:ENSG00000119689 DLST
HGNC:2911 DLST
KEGG:hsa:1743 DLST
Monarch:1743 DLST
NCBI Gene:1743 DLST
OMIM:126063 DLST
UCSC:P36957 DLST
Reference Transcript
RefSeq:NM_001933.4 DLST
Other Identifiers
11720929_a_at
11720930_s_at
11720931_x_at
11720932_s_at
11748080_a_at
11751226_x_at
11761177_at
16786524
1743
215210_PM_s_at
215210_s_at
2418675
2418678
2418682
2418684
2418687
2418688
33257_at
33258_g_at
3544349
3544350
3544351
3544352
3544353
3544354
3544355
3544356
3544357
3544358
3544360
3544361
3544362
3544363
3544364
3544365
3544367
3544368
3544369
3544370
3544372
3544373
3544374
3544375
3544376
3544377
3544378
3544379
3544380
3544381
45545_at
7975747
A_14_P109426
A_24_P13572
D26535_s_at
GE61495
GO:0003824
GO:0004149
GO:0005515
GO:0005634
GO:0005654
GO:0005739
GO:0005759
GO:0005829
GO:0006091
GO:0006099
GO:0006103
GO:0006104
GO:0006520
GO:0006790
GO:0016020
GO:0016740
GO:0016746
GO:0033512
GO:0043226
GO:0045252
GO:0055086
GO:0140096
GO:0160167
GO:1901135
HMNXSV003018081
HMNXSV003048834
Hs.296348.0.S1_3p_s_at
ILMN_1773228
PH_hs_0029663
PH_hs_0032549
TC14000465.hg
TC14001772.hg
Participates
as an output of
DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)
DLD dimer dehydrogenates dihydrolipoyl (Homo sapiens)
as an input of
DHTKD1 dimer decarboxylates 2-OA (Homo sapiens)
OGDH dimer decarboxylates 2-OG (Homo sapiens)
as a member of
Lipoylated DBT/DLST [mitochondrial matrix] (Homo sapiens)
as a component of
lipo-DLST trimer [mitochondrial matrix] (Homo sapiens)
Other forms of this molecule
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
LipoH2-K110-DLST [mitochondrial matrix]
DLST [mitochondrial matrix]
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
Inferred To
KGD2 [mitochondrial matrix]
(Saccharomyces cerevisiae)
odhB [mitochondrial matrix]
(Dictyostelium discoideum)
dlst-1 [mitochondrial matrix]
(Caenorhabditis elegans)
DLST [mitochondrial matrix]
(Bos taurus)
DLST [mitochondrial matrix]
(Canis familiaris)
DLST [mitochondrial matrix]
(Gallus gallus)
DLST [mitochondrial matrix]
(Sus scrofa)
Dlst [mitochondrial matrix]
(Drosophila melanogaster)
Dlst [mitochondrial matrix]
(Mus musculus)
Dlst [mitochondrial matrix]
(Rattus norvegicus)
kgd2 [mitochondrial matrix]
(Schizosaccharomyces pombe)
Lipo-K110-DLST [mitochondrial matrix]
(Plasmodium falciparum)
dlst [mitochondrial matrix]
(Danio rerio)
dlst [mitochondrial matrix]
(Xenopus tropicalis)
Modified Residues
Name
N6-lipoyl-L-lysine at 110
Coordinate
110
PsiMod Name
N6-lipoyl-L-lysine [MOD:00127]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-lipoyl-L-lysine.
Cross References
RefSeq
NP_001924.2
OpenTargets
ENSG00000119689
ENSEMBL
ENSP00000335304
,
ENST00000334220
IntEnz
2.3.1.61
HPA
ENSG00000119689-DLST
PRO
P36957
Pharos - Targets
P36957
GlyGen
P36957
HMDB Protein
HMDBP00939
PDB
6H05
Interactors (81)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P43686 PSMC4
2
PSMC4 [nucleoplasm]
(R-HSA-174315)
PSMC4 [cytosol]
(R-HSA-68777)
0.666
5
UniProt:Q96EF9 ZHX1R
0.556
3
UniProt:Q68CL5-3 TPGS2
0.556
3
UniProt:P09471 GNAO1
1
GNAO1 [plasma membrane]
(R-HSA-2997536)
0.556
3
UniProt:O75175 CNOT3
1
CNOT3 [cytosol]
(R-HSA-429872)
0.556
3
UniProt:Q9NX07 TSAP1
0.556
3
UniProt:Q7Z698 SPRED2
2
SPRED2 [cytosol]
(R-HSA-5654211)
SPRED2 [plasma membrane]
(R-HSA-5658229)
0.556
3
IntAct:EBI-25833913 CCSB
0.556
3
UniProt:Q3SY56 SP6
0.556
3
IntAct:EBI-25831691 CCSB
0.556
3
UniProt:Q96E17 RAB3C
2
GGC-RAB3C [cytosol]
(R-HSA-8874012)
RAB3C [cytosol]
(R-HSA-8873684)
0.556
3
UniProt:Q9NVM1 EVA1B
0.556
3
UniProt:O94983-5 CAMTA2
0.556
3
UniProt:Q9HC98-4 NEK6
0.556
3
UniProt:P36382 GJA5
1
GJA5 [endoplasmic reticulum membrane]
(R-HSA-190648)
0.556
3
UniProt:Q7Z780 Q7Z780
0.556
3
UniProt:Q96GK7 FAH2A
0.556
3
UniProt:Q8TAB5 CA216
0.556
3
UniProt:Q02978 SLC25A11
1
SLC25A11 [mitochondrial inner membrane]
(R-HSA-198451)
0.556
3
UniProt:P49184 DNASE1L1
2
DNASE1L1 [extracellular region]
(R-HSA-6806320)
DNASE1L1 [specific granule lumen]
(R-HSA-6799554)
0.556
3
UniProt:Q96L03 SPT17
0.556
3
UniProt:Q9H2S6-2 TNMD
0.556
3
UniProt:F6Y2X3 F6Y2X3
0.556
3
UniProt:Q96I25 RBM17
1
RBM17 [nucleoplasm]
(R-HSA-8865891)
0.556
3
UniProt:A2RUH7 MBPHL
0.556
3
UniProt:Q9BT49 THAP7
0.556
3
UniProt:Q8N1W1-4 ARHGEF28
0.556
3
UniProt:Q9Y617 PSAT1
1
PXLP-K200-PSAT1 [cytosol]
(R-HSA-977330)
0.556
3
UniProt:Q9BQ29 Q9BQ29
0.556
3
UniProt:Q8TB02 Q8TB02
0.556
3
UniProt:P43356 MAGA2
0.556
3
UniProt:Q96JJ7-2 Q96JJ72
0.556
3
UniProt:P14060 HSD3B1
1
HSD3B1 [endoplasmic reticulum membrane]
(R-HSA-192072)
0.556
3
UniProt:P79483 HLA-DRB3
9
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lumenal side of endoplasmic reticulum membrane]
(R-HSA-2130513)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [ER to Golgi transport vesicle membrane]
(R-HSA-2130432)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [Golgi membrane]
(R-HSA-2214381)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [trans-Golgi network membrane]
(R-HSA-2130452)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [transport vesicle membrane]
(R-HSA-2130559)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130515)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [endocytic vesicle membrane]
(R-HSA-2130377)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [lysosomal membrane]
(R-HSA-2130676)
HLA class II histocompatibility antigen, DRB3-1 beta chain precursor [plasma membrane]
(R-HSA-197577)
0.556
3
UniProt:Q6P4D5-2 PABIR3
0.556
3
UniProt:Q9ULW0 TPX2
2
TPX2 [nucleoplasm]
(R-HSA-2564700)
TPX2 [cytosol]
(R-HSA-8853407)
0.556
3
UniProt:Q6P5S2 LEG1H
0.556
3
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.556
3
UniProt:O75317 USP12
1
USP12 [nucleoplasm]
(R-HSA-5696907)
0.556
3
IntAct:EBI-25834143 CCSB
0.556
3
IntAct:EBI-25833532 RZPDO839F06154
0.556
3
UniProt:P16422 EPCAM
1
EPCAM [plasma membrane]
(R-HSA-375068)
0.556
3
UniProt:P26715 KLRC1
1
KLRC1 [plasma membrane]
(R-HSA-3006545)
0.556
3
UniProt:Q13200 PSMD2
5
PSMD2 [cytosol]
(R-HSA-68796)
PSMD2 [nucleoplasm]
(R-HSA-174311)
PSMD2 [secretory granule lumen]
(R-HSA-6800919)
PSMD2 [extracellular region]
(R-HSA-6806479)
PSMD2 [ficolin-1-rich granule lumen]
(R-HSA-6800435)
0.556
3
UniProt:Q10981 FUT2
1
FUT2 [Golgi membrane]
(R-HSA-2980904)
0.556
3
UniProt:P61224 RAP1B
2
RAP1B [plasma membrane]
(R-HSA-377590)
RAP1B [azurophil granule membrane]
(R-HSA-6804972)
0.556
3
UniProt:P07437 TUBB
3
TUBB [extracellular region]
(R-HSA-380317)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [cytosol]
(R-HSA-9020816)
0.556
3
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.556
3
UniProt:P52756 RBM5
1
RBM5 [nucleoplasm]
(R-HSA-72049)
0.556
3
UniProt:Q8N2W9 PIAS4
2
PIAS4 [nucleoplasm]
(R-HSA-2993789)
monoSUMO1-K35-PIAS4 [nucleoplasm]
(R-HSA-3968415)
0.556
3
UniProt:Q7Z6Z7-2 HUWE1
0.556
3
UniProt:Q6UXH1-2 CRELD2
0.556
3
UniProt:Q8N323 NXPE1
0.556
3
UniProt:Q9NPC7 MYNN
0.556
3
UniProt:Q8IY82 DRC7
0.556
3
IntAct:EBI-25833683 CCSB
0.556
3
UniProt:Q96P20 NLRP3
2
NLRP3 [cytosol]
(R-HSA-561189)
K63polyUb-NLRP3 [cytosol]
(R-HSA-6783288)
0.556
3
IntAct:EBI-25833762 CCSB
0.556
3
UniProt:P09382 LGALS1
2
LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8956711)
p-LGALS1 [endoplasmic reticulum lumen]
(R-HSA-8957003)
0.556
3
UniProt:Q8NCR3 MFI
0.556
3
UniProt:P50749 RASF2
0.556
3
UniProt:Q8NCF5-2 NFATC2IP
0.556
3
UniProt:Q99944 EGFL8
0.556
3
UniProt:O14829 PPEF1
1
PPEF1 [cytosol]
(R-HSA-2632517)
0.556
3
UniProt:Q96QH2 PRAM
0.556
3
UniProt:Q9Y3Y4 PYGO1
1
PYGO1 [nucleoplasm]
(R-HSA-201705)
0.556
3
UniProt:Q9ULR0 ISY1
1
ISY1 [nucleoplasm]
(R-HSA-6781963)
0.556
3
UniProt:O00214-2 LGALS8
0.556
3
UniProt:A0JP07 A0JP07
0.556
3
UniProt:P48775 TDO2
1
TDO2 [cytosol]
(R-HSA-71184)
0.556
3
UniProt:P49746 THBS3
1
THBS3 [extracellular region]
(R-HSA-66522)
0.556
3
UniProt:Q96EY8 MMAB
4
MMAB E193K [mitochondrial matrix]
(R-HSA-3322150)
MMAB R191W [mitochondrial matrix]
(R-HSA-3322112)
MMAB R186W [mitochondrial matrix]
(R-HSA-3322128)
MMAB [mitochondrial matrix]
(R-HSA-2980970)
0.556
3
UniProt:Q8NBT0 POC1A
0.556
3
UniProt:Q13636 RAB31
5
GGC-RAB31 [early endosome membrane]
(R-HSA-8877278)
GGC-RAB31 [cytosol]
(R-HSA-8873974)
RAB31 [cytosol]
(R-HSA-8873690)
RAB31 [plasma membrane]
(R-HSA-6804813)
RAB31 [secretory granule membrane]
(R-HSA-6804797)
0.556
3
UniProt:O75874 IDH1
10
IDH1 [cytosol]
(R-HSA-389549)
IDH1 [peroxisomal matrix]
(R-HSA-389546)
IDH1 [secretory granule lumen]
(R-HSA-6800980)
IDH1 [extracellular region]
(R-HSA-6806433)
IDH1 [tertiary granule lumen]
(R-HSA-6800163)
IDH1 [ficolin-1-rich granule lumen]
(R-HSA-6800977)
IDH1 R132C mutant [cytosol]
(R-HSA-880031)
IDH1 R132S mutant [cytosol]
(R-HSA-880048)
IDH1 R132L mutant [cytosol]
(R-HSA-880000)
IDH1 R132H mutant [cytosol]
(R-HSA-880015)
0.556
3
UniProt:P55209 NP1L1
0.547
3
UniProt:P09622 DLD
8
DLD [mitochondrial matrix]
(R-HSA-69978)
M361V DLD [mitochondrial matrix]
(R-HSA-9907714)
I393T DLD [mitochondrial matrix]
(R-HSA-9907713)
E375K DLD [mitochondrial matrix]
(R-HSA-9907711)
R495G DLD [mitochondrial matrix]
(R-HSA-9907710)
G229C DLD [mitochondrial matrix]
(R-HSA-9907709)
D479V DLD [mitochondrial matrix]
(R-HSA-9907708)
I47T DLD [mitochondrial matrix]
(R-HSA-9907707)
0.527
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.499
4
UniProt:P06493 CDK1
11
p-T161-CDK1 [nucleoplasm]
(R-HSA-170066)
p-T14,Y15,T161-CDK1 [nucleoplasm]
(R-HSA-170074)
p-T161-CDK1 [cytosol]
(R-HSA-157415)
p-T14,Y15,T161-CDK1 [cytosol]
(R-HSA-170071)
CDK1 [cytosol]
(R-HSA-170075)
CDK1 [nucleoplasm]
(R-HSA-68889)
p-T14-CDK1 [cytosol]
(R-HSA-170064)
p-T14-CDK1 [nucleoplasm]
(R-HSA-170045)
p-T14,T161-CDK1 [nucleoplasm]
(R-HSA-170078)
p-Y4-CDK1 [cytosol]
(R-HSA-9836187)
CDK1 [endoplasmic reticulum membrane]
(R-HSA-264424)
0.499
3
UniProt:Q9H9B4 SFXN1
0.483
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
8
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