Reactome | PCK1 phosphorylates OA to yield PEP

PCK1 phosphorylates OA to yield PEP

Stable Identifier

R-HSA-70241

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate

ReviewStatus

5/5

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The transfer of a high-energy phosphate bond from GTP to oxaloacetate (OA), to form phosphoenolpyruvate (PEP), GDP, and CO2, is catalyzed by cytosolic phosphoenolpyruvate carboxykinase PCK1 (Dunten et al. 2002). This reaction is irreversible under physiological conditions.

Literature References

PubMed ID	Title	Journal	Year
11851336	Crystal structure of human cytosolic phosphoenolpyruvate carboxykinase reveals a new GTP-binding site Dunten, P, Belunis, C, Crowther, R, Hollfelder, K, Kammlott, U, Levin, W, Michel, H, Ramsey, GB, Swain, A, Weber, D, Wertheimer, SJ	J Mol Biol	2002