Reactome | GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc

GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc

Stable Identifier

R-HSA-70369

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

UDP-alpha-D-galactose=> UDP-alpha-D-glucose, UDP-galactose <=> UDP-glucose

ReviewStatus

5/5

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GALE:NAD+ dimer reversibly epimerises UDP-Gal to UDP-Glc

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Cytosolic UDP-galactose 4-epimerase catalyzes the interconversion of UDP-D-galactose and UDP-D-glucose (Schulz et al. 2004). The active form of the enzyme is a homodimer with one molecule of bound NAD+ per monomer (Thoden et al. 2000).

Literature References

PubMed ID	Title	Journal	Year
10801319	Crystallographic evidence for Tyr 157 functioning as the active site base in human UDP-galactose 4-epimerase Thoden, JB, Wohlers, TM, Fridovich-Keil, JL, Holden, HM	Biochemistry	2000
15175331	Determinants of function and substrate specificity in human UDP-galactose 4'-epimerase Schulz, JM, Watson, AL, Sanders, R, Ross, KL, Thoden, JB, Holden, HM, Fridovich-Keil, JL	J Biol Chem	2004