D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate

Stable Identifier
R-HSA-70475
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
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The reversible isomerization of fructose-6-phosphate to form glucose-6-phosphate is catalyzed by cytosolic phosphoglucose isomerase (Noltman 1972; Xu and Beutler 1994; Tsuboi et al. 1958).

Literature References
PubMed ID Title Journal Year
13538944 Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.

Tsuboi, KK, Estrada, J, Hudson, PB

J Biol Chem 1958
7989588 The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia

Xu, W, Beutler, E

J Clin Invest 1994
  The Enzymes, 3rd ed

Boyer, PD

  1972
Participants
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Event Information
Reverse Reaction
alpha-D-glucose 6-phosphate <=> D-fructose 6-phosphate (Homo sapiens)
Catalyst Activity

glucose-6-phosphate isomerase activity of GPI dimer [cytosol]

Physical Entity
GPI dimer [cytosol] (Homo sapiens)
Activity
glucose-6-phosphate isomerase activity (GO:0004347)
Orthologous Events
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Caenorhabditis elegans)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Canis familiaris)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Danio rerio)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Dictyostelium discoideum)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Drosophila melanogaster)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Gallus gallus)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Mus musculus)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Plasmodium falciparum)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Rattus norvegicus)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Saccharomyces cerevisiae)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Schizosaccharomyces pombe)
Authored
Schmidt, EE  (2003-02-05)
Reviewed
D'Eustachio, P  (2003-06-25)
Harris, RA  (2008-09-10)
Inga, A  (2016-02-04)
Zaccara, S  (2016-02-04)
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