Reactome | GPI dimer isomerizes Fru(6)P to G6P

GPI dimer isomerizes Fru(6)P to G6P

Stable Identifier

R-HSA-70475

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

beta-D-fructose 6-phosphate => alpha-D-glucose 6-phosphate

ReviewStatus

5/5

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The reversible isomerization of Fru(6)P (fructose-6-phosphate) to form G6P (glucose-6-phosphate) is catalyzed by cytosolic GPI (phosphoglucose isomerase) dimer (Noltman 1972; Tsuboi et al. 1958; Xu and Beutler 1994).

Literature References

PubMed ID	Title	Journal	Year
7989588	The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia Beutler, E, Xu, W	J Clin Invest	1994
13538944	Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties. Tsuboi, KK, Hudson, PB, Estrada, J	J Biol Chem	1958
	The Enzymes, 3rd ed Boyer, PD		1972