D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate

Stable Identifier
R-HSA-70475
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate
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The reversible isomerization of fructose-6-phosphate to form glucose-6-phosphate is catalyzed by cytosolic phosphoglucose isomerase (Noltman 1972; Xu and Beutler 1994; Tsuboi et al. 1958).

Literature References
PubMed ID Title Journal Year
7989588 The characterization of gene mutations for human glucose phosphate isomerase deficiency associated with chronic hemolytic anemia

Beutler, E, Xu, W

J Clin Invest 1994
13538944 Enzymes of the human erythrocyte. IV. Phosphoglucose isomerase, purification and properties.

Tsuboi, KK, Hudson, PB, Estrada, J

J Biol Chem 1958
  The Enzymes, 3rd ed

Boyer, PD

  1972
Participants
Input
Output
Participates
as an event of
Catalyst Activity

glucose-6-phosphate isomerase activity of GPI dimer [cytosol]

Physical Entity
GPI dimer [cytosol] (Homo sapiens)
Activity
glucose-6-phosphate isomerase activity (GO:0004347)
Orthologous Events
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Bos taurus)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Caenorhabditis elegans)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Canis familiaris)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Danio rerio)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Dictyostelium discoideum)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Drosophila melanogaster)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Gallus gallus)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Mus musculus)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Plasmodium falciparum)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Rattus norvegicus)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Saccharomyces cerevisiae)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Schizosaccharomyces pombe)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Sus scrofa)
D-fructose 6-phosphate <=> alpha-D-Glucose 6-phosphate (Xenopus tropicalis)
Cross References
Rhea
Authored
Schmidt, EE  (2003-02-05)
Reviewed
D'Eustachio, P  (2003-06-25)
Zaccara, S  (2016-02-04)
Inga, A  (2016-02-04)
Harris, RA  (2008-09-10)
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