Reactome | FBP1 [cytosol]

FBP1 [cytosol]

Stable Identifier

R-HSA-70476

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fructose-1,6-bisphosphatase 1, D-fructose-1,6-bisphosphate 1-phosphohydrolase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P09467 FBP1

Gene Names

FBP1, FBP

Chain

initiator methionine:1, chain:2-338

Reference Genes

BioGPS Gene:2203 FBP1

COSMIC (genes):FBP1 FBP1

CTD Gene:2203 FBP1

dbSNP Gene:2203 FBP1

ENSEMBL:ENSG00000165140 FBP1

HGNC:3606 FBP1

KEGG Gene (Homo sapiens):2203 FBP1

Monarch:2203 FBP1

NCBI Gene:2203 FBP1

OMIM:611570 FBP1

UCSC:P09467 FBP1

Reference Transcript

Other Identifiers

0006590390

11721491_a_at

17096030

209696_at

2203

3215571

3215572

3215573

3215574

3215575

3215577

3215579

3215580

3215584

3215586

3215587

3215590

3215591

3215592

3215593

36495_at

8162502

A_23_P257111

GE57858

GE60530

GO:0000122

GO:0001085

GO:0003674

GO:0003824

GO:0005515

GO:0005575

GO:0005576

GO:0005615

GO:0005622

GO:0005634

GO:0005737

GO:0005829

GO:0005975

GO:0005986

GO:0006000

GO:0006002

GO:0006091

GO:0006094

GO:0006111

GO:0007165

GO:0008134

GO:0008150

GO:0008152

GO:0009056

GO:0009058

GO:0016208

GO:0016311

GO:0016787

GO:0016791

GO:0030308

GO:0030388

GO:0034641

GO:0035690

GO:0040007

GO:0042132

GO:0042578

GO:0042802

GO:0043167

GO:0043226

GO:0044281

GO:0045820

GO:0046580

GO:0046872

GO:0048029

GO:0070062

GO:0071286

HMNXSV003051252

ILMN_1728799

PH_hs_0024020

TC09001357.hg

U21931_at

g439225_3p_at

Participates

as a component of

FBP1 tetramer [cytosol] (Homo sapiens)

Inferred To

fbp1b [cytosol] (Danio rerio)

fbp-1 [cytosol] (Caenorhabditis elegans)

FBP1 [cytosol] (Bos taurus)

FBP1 [cytosol] (Canis familiaris)

FBP1 [cytosol] (Gallus gallus)

FBP1 [cytosol] (Saccharomyces cerevisiae)

fbp1 [cytosol] (Schizosaccharomyces pombe)

fbp1 [cytosol] (Xenopus tropicalis)

fbp [cytosol] (Dictyostelium discoideum)

fbp [cytosol] (Drosophila melanogaster)

Fbp1 [cytosol] (Mus musculus)

Fbp1 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

NP_000498.2, NP_001121100.1

OpenTargets

ENSG00000165140

IntEnz

3.1.3.11

GeneCards

P09467

HPA

ENSG00000165140-FBP1

ZINC target

P09467

Ensembl

ENST00000375326, ENST00000415431, ENSG00000165140, ENSP00000408025, ENSP00000364475

PRO

P09467

Orphanet

16034

HMDB Protein

HMDBP00803

PDB

3KC0, 6LS5, 2WBD, 6LW2, 5Q06, 5PZY, 2FIX, 5PZQ, 2Y5K, 5Q07, 2WBB, 5PZR, 5PZZ, 2FHY, 2VT5, 5Q04, 5PZW, 5Q0B, 1FTA, 3KC1, 5Q05, 2Y5L, 5PZX, 3KBZ, 3A29, 7CVN, 4MJO, 5Q02, 5PZU, 2JJK, 5Q0A, 5Q03, 5PZV, 5Q08, 5Q00, 5PZS, 5LDZ, 2FIE, 5Q09, 5PZT, 5Q01

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q16665 HIF1A	7	2xHP-HIF1A [nucleoplasm] (R-HSA-1234105) HN-HIF1A [cytosol] (R-HSA-1234110) 2xHP-HIF1A [cytosol] (R-HSA-1234131) p-Y565,S797-HIF1A [cytosol] (R-HSA-9634700) p-Y565-HIF1A [cytosol] (R-HSA-8857584) HIF1A [cytosol] (R-HSA-1234102) HIF1A [nucleoplasm] (R-HSA-1234135)	0.602	5
UniProt:Q99814 EPAS1	5	2xHP-EPAS1 [nucleoplasm] (R-HSA-1234151) HN-EPAS1 [cytosol] (R-HSA-1234112) 2xHP-EPAS1 [cytosol] (R-HSA-1234149) EPAS1 [cytosol] (R-HSA-1234119) EPAS1 [nucleoplasm] (R-HSA-452560)	0.602	4
UniProt:P42858 HTT	1	HTT [nucleoplasm] (R-HSA-9023590)	0.556	3