Cytosolic FBP (fructose-1,6-bisphosphatase) tetramers catalyze the physiologically irreversible hydrolysis of F1,6PP (fructose-1,6-bisphosphate) to form Fru(6)P (fructose-6-phosphate) and Pi (orthophosphate). In the body, two isoforms of the enzyme are expressed, one ubiquitous and one muscle-specific (Kikawa et al. 1997; Tillmann and Eschrich 1998).
Nakai, A, Taketo, A, Sudo, M, Yamamoto, Y, Jin, BY, Fujisawa, K, Hata, I, Mayumi, M, Kaji, S, Inuzuka, M, Kikawa, Y, Mizunuma, H, Shigematsu, Y, Koga, J-i
Tillmann, H, Eschrich, K
fructose 1,6-bisphosphate 1-phosphatase activity of FBP tetramer [cytosol]
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