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LDHA [cytosol]
Stable Identifier
R-HSA-70502
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
lactate dehydrogenase A, L-lactate dehydrogenase A chain , LDH-A, LDH muscle subunit, LDH-M
Locations in the PathwayBrowser for interactor UniProt:P00338 LDHA
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Pyruvate metabolism (Homo sapiens)
Regulation of pyruvate metabolism (Homo sapiens)
CTLH E3 ligase ubiquitinates LDHA (Homo sapiens)
LDHA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00338 LDHA
Gene Names
LDHA, PIG19
Chain
initiator methionine:, chain:2-332
Reference Genes
BioGPS Gene:3939 LDHA
COSMIC (genes):LDHA LDHA
CTD Gene:3939 LDHA
dbSNP Gene:3939 LDHA
ENSEMBL:ENSG00000134333 LDHA
ENSEMBL_homo_sapiens_GENE:ENSG00000134333.15 LDHA
ENSEMBL_homo_sapiens_GENE:ENSG00000288299.1 LDHA
HGNC:6535 LDHA
KEGG Gene (Homo sapiens):3939 LDHA
Monarch:3939 LDHA
NCBI Gene:3939 LDHA
OMIM:150000 LDHA
UCSC:P00338 LDHA
Reference Transcript
RefSeq:NM_001135239.1 LDHA
RefSeq:NM_001165415.1 LDHA
RefSeq:NM_001165414.1 LDHA
RefSeq:NM_005566.3 LDHA
RefSeq:NM_001165416.1 LDHA
Other Identifiers
11733020_s_at
11733021_x_at
11742116_x_at
11756723_x_at
16722603
200650_PM_s_at
200650_s_at
2386590
2478578
2478586
2478587
3199613
3199615
3322776
3322777
3322781
3322782
3322783
3322784
3322785
3322788
3322790
3322792
3322794
3322795
3322797
3322800
3322801
3322802
3322803
3322804
3322805
3322806
3939
41485_at
7938777
A_23_P47565
GE59637
GO:0003824
GO:0004459
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0005975
GO:0006089
GO:0006090
GO:0006091
GO:0006096
GO:0016020
GO:0016491
GO:0016616
GO:0019752
GO:0021762
GO:0042802
GO:0043226
GO:0045296
GO:0048856
GO:0055086
GO:0070062
GO:1901135
GO:1990204
HMNXSV003053356
ILMN_1807106
PH_hs_0028715
TC11000240.hg
TC11002588.hg
X02152_at
g5031856_3p_a_at
Participates
as an input of
CTLH E3 ligase ubiquitinates LDHA (Homo sapiens)
as a component of
lactate dehydrogenase A4 complex [cytosol] (Homo sapiens)
lactate dehydrogenase AB3 complex [cytosol] (Homo sapiens)
lactate dehydrogenase A3B complex [cytosol] (Homo sapiens)
lactate dehydrogenase A2B2 complex [cytosol] (Homo sapiens)
Other forms of this molecule
PolyUb-LDHA [cytosol]
Inferred To
LDHA [cytosol]
(Bos taurus)
LDHA [cytosol]
(Caenorhabditis elegans)
LDHA [cytosol]
(Danio rerio)
LDHA [cytosol]
(Drosophila melanogaster)
LDHA [cytosol]
(Gallus gallus)
LDHA [cytosol]
(Mus musculus)
LDHA [cytosol]
(Rattus norvegicus)
LDHA [cytosol]
(Sus scrofa)
LDHA [cytosol]
(Xenopus tropicalis)
LOC490690 [cytosol]
(Canis familiaris)
Homologues of LDHA [cytosol]
(Drosophila melanogaster)
Cross References
RefSeq
NP_001158886.1
,
NP_001158887.1
,
NP_005557.1
,
NP_001128711.1
,
NP_001158888.1
OpenTargets
ENSG00000134333
ZINC - Substances
LDHA_HUMAN
ZINC target
P00338
PRO
P00338
PDB
4QSM
,
6SBU
,
7M2N
,
6MVA
,
6ZZR
,
4L4R
,
4M49
,
4QT0
,
6Q0D
,
8FW6
,
4R69
,
5ZJF
,
6BAG
,
6SBV
,
6BAX
,
4L4S
,
6Q13
,
4OJN
,
5W8H
,
4ZVV
,
4RLS
,
5W8I
,
4QO7
,
6BB1
,
4JNK
,
5IXS
,
1I10
,
5W8J
,
4AJP
,
6BB0
,
4QO8
,
6BAZ
,
5W8K
,
6BB3
,
6MV8
,
5ZJE
,
4OKN
,
5IXY
,
5W8L
,
4R68
,
5ZJD
,
6BB2
,
6BAD
HPA
ENSG00000134333-LDHA
GeneCards
P00338
Ensembl
ENSP00000499898
,
ENSP00000445331
,
ENST00000227157
,
ENSP00000368722
,
ENSP00000499977
,
ENST00000673083
,
ENSG00000288299
,
ENST00000672405
,
ENST00000430553
,
ENSP00000395337
,
ENST00000673204
,
ENSP00000227157
,
ENSP00000500354
,
ENSP00000379524
,
ENST00000542179
,
ENST00000671981
,
ENST00000672078
,
ENST00000396222
,
ENST00000672996
,
ENSG00000134333
,
ENSP00000500168
,
ENST00000673007
,
ENSP00000500953
,
ENSP00000500284
,
ENSP00000406172
,
ENST00000379412
,
ENST00000422447
,
ENSP00000500603
Pharos - Targets
P00338
ZINC - Predictions - Purchasable
LDHA_HUMAN
Orphanet
16344
HMDB Protein
HMDBP03579
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07195 LDHB
1
LDHB [cytosol]
(R-HSA-70503)
0.804
5
UniProt:P07864 LDHC
1
LDHC [cytosol]
(R-HSA-6807524)
0.708
6
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
20
UniProt:P00338 LDHA
2
PolyUb-LDHA [cytosol]
(R-HSA-9861549)
LDHA [cytosol]
(R-HSA-70502)
0.668
3
UniProt:P11142 HSPA8
10
Me3K561-HSPA8 [nucleoplasm]
(R-HSA-8932217)
HSPA8 [secretory granule lumen]
(R-HSA-6801530)
HSPA8 [extracellular region]
(R-HSA-6805936)
HSPA8 [ficolin-1-rich granule lumen]
(R-HSA-6801494)
HSPA8 [nucleoplasm]
(R-HSA-5082380)
HSPA8 [plasma membrane]
(R-HSA-936508)
HSPA8 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane]
(R-HSA-888599)
HSPA8 [late endosome lumen]
(R-HSA-9631104)
HSPA8 [lysosomal lumen]
(R-HSA-9625182)
HSPA8 [cytosol]
(R-HSA-264476)
0.639
4
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
5
UniProt:P0DTD1-PRO_0000449630 REP
0.527
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.527
3
UniProt:P0DTD1-PRO_0000449627 REP
0.482
2
ChEBI:16851 1-PHOSPHATIDYL-1D-MYO-INOSITOL 3,5-BISPHOSPHATE
0.462
2
ChEBI:18348 1-PHOSPHATIDYL-1D-MYO-INOSITOL 4,5-BISPHOSPHATE
0.462
2
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