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CPS1 [mitochondrial matrix]
Stable Identifier
R-HSA-70544
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
carbamoyl-phosphate synthetase I, carbamoyl-phosphate synthase (ammonia), mitochondrial, CPSase I
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Urea cycle (Homo sapiens)
2 ATP + NH4+ + HCO3- => 2 ADP + orthophosphate + carbamoyl phosphate [mitochondrial] (Homo sapiens)
CPS1 [mitochondrial matrix] (Homo sapiens)
External Reference Information
External Reference
UniProt:P31327 CPS1
Gene Names
CPS1
Chain
transit peptide:1-38, chain:39-1500
Reference Genes
BioGPS Gene:1373 CPS1
COSMIC (genes):CPS1 CPS1
CTD Gene:1373 CPS1
dbSNP Gene:1373 CPS1
ENSEMBL:ENSG00000021826 CPS1
HGNC:2323 CPS1
KEGG:hsa:1373 CPS1
Monarch:1373 CPS1
NCBI Gene:1373 CPS1
OMIM:608307 CPS1
UCSC:P31327 CPS1
Reference Transcript
RefSeq:NM_001122634.3 CPS1
RefSeq:XM_011510641.2 CPS1
RefSeq:NM_001122633.2 CPS1
RefSeq:NM_001875.4 CPS1
RefSeq:XM_011510644.2 CPS1
RefSeq:XM_011510642.2 CPS1
RefSeq:XM_011510643.2 CPS1
Other Identifiers
11721219_a_at
11741247_a_at
11755015_s_at
1373
16890347
204920_PM_at
204920_at
217564_PM_s_at
217564_s_at
2525990
2525995
2526003
2526004
2526012
2526013
2526015
2526016
2526017
2526018
2526019
2526020
2526022
2526024
2526025
2526027
2526028
2526029
2526030
2526031
2526033
2526034
2526036
2526038
2526039
2526040
2526041
2526042
2526043
2526050
2526051
2526052
2526054
2526055
2526056
2526057
2526059
2526060
2526061
2526062
2526063
2526066
2526067
2526068
2526069
2526070
2526071
2526072
2526073
2526074
2526075
2526076
2526077
2526078
2526079
34884_at
8048026
A_14_P108650
A_14_P109326
A_14_P111051
A_14_P121491
A_23_P5300
A_33_P3242798
D90282_at
GE57447
GO:0000050
GO:0001889
GO:0003013
GO:0003824
GO:0004087
GO:0004088
GO:0004175
GO:0005509
GO:0005515
GO:0005524
GO:0005543
GO:0005634
GO:0005730
GO:0005737
GO:0005739
GO:0005743
GO:0005759
GO:0005886
GO:0006207
GO:0006520
GO:0006541
GO:0006629
GO:0006790
GO:0007494
GO:0008289
GO:0009410
GO:0009636
GO:0010043
GO:0014075
GO:0016595
GO:0016787
GO:0016874
GO:0019240
GO:0019433
GO:0019637
GO:0030154
GO:0030955
GO:0032094
GO:0032496
GO:0032991
GO:0033762
GO:0034201
GO:0036094
GO:0042311
GO:0042594
GO:0042645
GO:0043200
GO:0043226
GO:0044344
GO:0044877
GO:0046209
GO:0046872
GO:0048545
GO:0048856
GO:0050667
GO:0051384
GO:0051591
GO:0055081
GO:0055086
GO:0060416
GO:0070365
GO:0070409
GO:0071242
GO:0071320
GO:0071377
GO:0071400
GO:0071548
GO:0071941
GO:0072341
GO:0140096
HMNXSV003026373
Hs.326685.0.A1_3p_s_at
ILMN_1792748
PH_hs_0036028
TC02001246.hg
g5020419_3p_at
Inferred To
CPS1 [mitochondrial matrix]
(Bos taurus)
CPS1 [mitochondrial matrix]
(Canis familiaris)
CPS1 [mitochondrial matrix]
(Gallus gallus)
CPS1 [mitochondrial matrix]
(Mus musculus)
CPS1 [mitochondrial matrix]
(Rattus norvegicus)
CPS1 [mitochondrial matrix]
(Saccharomyces cerevisiae)
CPS1 [mitochondrial matrix]
(Schizosaccharomyces pombe)
CPS1 [mitochondrial matrix]
(Sus scrofa)
cps1 [mitochondrial matrix]
(Xenopus tropicalis)
Cross References
OpenTargets
ENSG00000021826
ENSEMBL
ENSP00000501022
,
ENST00000430249
,
ENST00000233072
,
ENST00000451903
,
ENST00000673630
,
ENSP00000501073
,
ENST00000673510
,
ENSP00000500537
,
ENSP00000402608
,
ENSP00000233072
,
ENSP00000406136
,
ENST00000673711
IntEnz
6.3.4.16
HPA
ENSG00000021826-CPS1
PRO
P31327
Pharos - Targets
P31327
Orphanet
CPS1
GlyGen
P31327
HMDB Protein
HMDBP00359
PDB
5DOT
,
5DOU
,
6W2J
,
5OJO
,
4UTR
,
4UU8
,
4UU7
,
2YVQ
,
4UTV
,
4UUB
,
6UEL
,
4UUA
,
4UTZ
,
4UTX
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.564
2
UniProt:O95861 BPNT1
1
BPNT1 [cytosol]
(R-HSA-176573)
0.527
2
UniProt:P58557 YBEY
0.527
2
UniProt:Q5J5C9 DEFB121
3
DEFB121(?-76) [extracellular region]
(R-HSA-1471330)
DEFB121(?-76) [Golgi lumen]
(R-HSA-975806)
DEFB121(1-76) [Golgi lumen]
(R-HSA-1470037)
0.527
2
UniProt:Q9UK85 DKKL1
0.527
3
UniProt:Q96DR7 ARHGEF26
1
ARHGEF26 [cytosol]
(R-HSA-8873912)
0.527
3
UniProt:O75251 NDUFS7
1
NDUFS7 [mitochondrial matrix]
(R-HSA-6788521)
0.527
4
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