arginine + H2O => ornithine + urea [ARG1]

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic Arginase 1 (ARG1) trimer catalyzes the hydrolysis of arginine to yield ornithine and urea (DiCostanzo et al. 2005). Patients expressing mutated forms of the enzyme with diminished in vitro arginase activity can accumulate arginine to pathogenic levels in the blood (e.g., Uchino et al. 1995).

Literature References
PubMed ID Title Journal Year
16141327 Crystal structure of human arginase I at 1.29-A resolution and exploration of inhibition in the immune response

Centeno, F, Rodriguez, PC, Mora, A, Christianson, DW, Di Costanzo, L, Ochoa, AC, Sabio, G

Proc Natl Acad Sci U S A 2005
7649538 Molecular basis of phenotypic variation in patients with argininemia

Shapira, SK, Matsuda, I, Uchino, T, Lambert, M, Smit, LM, Qureshi, IA, Snyderman, SE, Sansaricq, C, Jakobs, C

Hum Genet 1995
Catalyst Activity

arginase activity of ARG1 trimer [cytosol]

Orthologous Events
Cross References
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