Cytosolic Arginase 1 (ARG1) trimer catalyzes the hydrolysis of arginine to yield ornithine and urea (DiCostanzo et al. 2005). Patients expressing mutated forms of the enzyme with diminished in vitro arginase activity can accumulate arginine to pathogenic levels in the blood (e.g., Uchino et al. 1995).
Centeno, F, Rodriguez, PC, Mora, A, Christianson, DW, Di Costanzo, L, Ochoa, AC, Sabio, G
Shapira, SK, Matsuda, I, Uchino, T, Lambert, M, Smit, LM, Qureshi, IA, Snyderman, SE, Sansaricq, C, Jakobs, C
arginase activity of ARG1 trimer [cytosol]
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