Reactome | PXLP-OAT(26-439) [mitochondrial matrix]

PXLP-OAT(26-439) [mitochondrial matrix]

Stable Identifier

R-HSA-70638

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ornithine aminotransferase, mitochondrial, OAT, ornithine-oxo-acid aminotransferase

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P04181 OAT

Gene Names

OAT

Chain

transit peptide:1-35, transit peptide:1-25, chain:26-439, chain:36-439

Reference Genes

BioGPS Gene:4942 OAT

COSMIC (genes):OAT OAT

CTD Gene:4942 OAT

dbSNP Gene:4942 OAT

ENSEMBL:ENSG00000065154 OAT

ENSEMBL:ENSG00000065154.12 OAT

HGNC:8091 OAT

KEGG Gene (Homo sapiens):4942 OAT

Monarch:4942 OAT

NCBI Gene:4942 OAT

OMIM:613349 OAT

UCSC:P04181 OAT

Reference Transcript

Other Identifiers

11757997_s_at

16719233

201599_PM_at

201599_at

3311159

3311160

3311161

3311162

3311163

3311166

3311167

3311172

3311173

3311174

3311175

3311176

3311181

3311183

36636_at

3976599

3976600

4007325

4007408

4007414

4942

7936871

A_23_P98092

GE57811

GO:0003824

GO:0004587

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0006520

GO:0007601

GO:0008483

GO:0010121

GO:0016740

GO:0019544

GO:0030170

GO:0042802

GO:0043226

GO:0050155

GO:0050877

GO:0055129

HMNXSV003019730

ILMN_1654441

ILMN_2068747

M29927_at

PH_hs_0004331

TC10001726.hg

g4557808_3p_at

Participates

as a component of

OAT hexamer [mitochondrial matrix] (Homo sapiens)

Inferred To

PXLP-OAT(26-439) [mitochondrial matrix] (Canis familiaris)

car2 [mitochondrial matrix] (Schizosaccharomyces pombe)

Oat [mitochondrial matrix] (Drosophila melanogaster)

Oat [mitochondrial matrix] (Mus musculus)

Oat [mitochondrial matrix] (Rattus norvegicus)

oatr-1 [mitochondrial matrix] (Caenorhabditis elegans)

OAT [mitochondrial matrix] (Bos taurus)

OAT [mitochondrial matrix] (Gallus gallus)

OAT [mitochondrial matrix] (Plasmodium falciparum)

OAT [mitochondrial matrix] (Sus scrofa)

CAR2 [mitochondrial matrix] (Saccharomyces cerevisiae)

oat.2 [mitochondrial matrix] (Xenopus tropicalis)

si:dkey-68e16.4 [mitochondrial matrix] (Danio rerio)

oatA [mitochondrial matrix] (Dictyostelium discoideum)

Modified Residues

Name

N6-pyridoxal phosphate-L-lysine at 292

Coordinate

292

PsiMod Name

N6-pyridoxal phosphate-L-lysine [MOD:00128]

PsiMod Definition

A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.

Cross References

RefSeq

NP_000265.1, NP_001309897.1, NP_001309894.1, NP_001309900.1, NP_001309896.1, NP_001309899.1, NP_001165285.1, NP_001309898.1, NP_001309895.1

OpenTargets

ENSG00000065154

IntEnz

2.6.1.13

HPA

ENSG00000065154-OAT

GeneCards

P04181

Ensembl

ENSG00000065154, ENSP00000439042, ENST00000539214, ENST00000368845, ENSP00000357838

PRO

P04181

Pharos - Targets

P04181

Orphanet

16583

HMDB Protein

HMDBP00400

PDB

7LNM, 7LK1, 2BYJ, 7LOM, 6V8D, 1OAT, 6OIA, 2BYL, 5VWO, 7T9Z, 7LK0, 6V8C, 2CAN, 7TA0, 7TA1, 7JX9, 6HX7, 1GBN, 2OAT, 7TEV, 7TED, 8EZ1, 7TFP, 7LON

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-687) [extracellular region] (R-HSA-9010033) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(18-770) [endosome lumen] (R-HSA-5229077) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP [endoplasmic reticulum lumen] (R-HSA-8956696) APP(672-711) [extracellular region] (R-HSA-976740) APP(672-711) [cytosol] (R-HSA-877188) APP(672-713) [extracellular region] (R-HSA-879340)	0.556	3

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