Reactome | ornithine => putrescine + CO2

ornithine => putrescine + CO2

Stable Identifier

R-HSA-70692

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

L-ornithine + H(+) => putrescine + CO2

ReviewStatus

4/5

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L-ornithine is converted into putrescine by cytosolic ornithine decarboxylase (ODC). The enzyme, conjugated with pyridoxal phosphate, is active as a dimer (Almrud et al. 2000; Dufe et al. 2007).

Literature References

PubMed ID	Title	Journal	Year
10623504	Crystal structure of human ornithine decarboxylase at 2.1 A resolution: structural insights to antizyme binding Almrud, JJ, Oliveira, MA, Kern, AD, Grishin, NV, Phillips, MA, Hackert, ML	J Mol Biol	2000
17407445	A structural insight into the inhibition of human and Leishmania donovani ornithine decarboxylases by 1-amino-oxy-3-aminopropane Dufe, VT, Ingner, D, Heby, O, Khomutov, AR, Persson, L, al-Karadaghi, S	Biochem J	2007