Reactome | HSD17B10 [mitochondrial matrix]

HSD17B10 [mitochondrial matrix]

Stable Identifier

R-HSA-70831

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

2-methyl-3-hydroxybutyryl-CoA dehydrogenase, HADH2, 3-hydroxyacyl-CoA dehydrogenase type II, endoplasmic reticulum-associated amyloid beta-peptide binding protein, 3-hydroxyacyl-CoA dehydrogenase type II , Endoplasmic reticulum-associated amyloid beta-peptide binding protein

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
12696021	2-Methyl-3-hydroxybutyryl-CoA dehydrogenase deficiency is caused by mutations in the HADH2 gene. Ofman, R, Ruiter, JP, Feenstra, M, Duran, M, Poll-The, BT, Zschocke, J, Ensenauer, R, Lehnert, W, Sass, JO, Sperl, W	Am J Hum Genet	2003

External Reference Information

External Reference

UniProt:Q99714 HSD17B10

Gene Names

HSD17B10, ERAB, HADH2, MRPP2, SCHAD, SDR5C1, XH98G2

Chain

initiator methionine:1, chain:2-261

Reference Genes

COSMIC (genes):HSD17B10 HSD17B10

dbSNP Gene:3028 HSD17B10

ENSEMBL:ENSG00000072506 HSD17B10

Participates

as a component of

as a member of

Substrate of LONP1 (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)

Inferred To

hsd17b10 [mitochondrial matrix] (Danio rerio)

hsd17b10 [mitochondrial matrix] (Xenopus tropicalis)

ard-1 [mitochondrial matrix] (Caenorhabditis elegans)

HSD17B10 [mitochondrial matrix] (Bos taurus)

HSD17B10 [mitochondrial matrix] (Canis familiaris)

HSD17B10 [mitochondrial matrix] (Dictyostelium discoideum)

HSD17B10 [mitochondrial matrix] (Drosophila melanogaster)

HSD17B10 [mitochondrial matrix] (Gallus gallus)

HSD17B10 [mitochondrial matrix] (Mus musculus)

HSD17B10 [mitochondrial matrix] (Rattus norvegicus)

HSD17B10 [mitochondrial matrix] (Sus scrofa)

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.747	7
UniProt:P05455 SSB	1	SSB [nucleoplasm] (R-HSA-58418)	0.527	2
UniProt:P13639 EEF2	10	EEF2 [secretory granule lumen] (R-HSA-6801504) EEF2 [extracellular region] (R-HSA-6806499) EEF2 [ficolin-1-rich granule lumen] (R-HSA-6801513) EEF2 [cytosol] (R-HSA-156901) aminocarboxypropyl EEF2 [cytosol] (R-HSA-5358478) Me-diphthine EEF2 [cytosol] (R-HSA-5367025) nascent EEF2 [cytosol] (R-HSA-5358472) diphthine EEF2 [cytosol] (R-HSA-5358501) ADP-ribo-EEF2 [cytosol] (R-HSA-5334764) Me3K525-EEF2 [cytosol] (R-HSA-8932237)	0.499	3
UniProt:Q12931 TRAP1	1	TRAP1 [mitochondrial matrix] (R-HSA-8874494)	0.499	3

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