Reactome | ADAM15 [plasma membrane]

ADAM15 [plasma membrane]

Stable Identifier

R-HSA-708329

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Disintegrin and metalloproteinase domain-containing protein 15, ADA15_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13444 ADAM15

Gene Names

ADAM15, MDC15

Chain

signal peptide:1-17, propeptide:18-206, chain:207-863

Reference Genes

BioGPS Gene:8751 ADAM15

COSMIC (genes):ADAM15 ADAM15

CTD Gene:8751 ADAM15

dbSNP Gene:8751 ADAM15

ENSEMBL:ENSG00000143537 ADAM15

ENSEMBL_homo_sapiens_GENE:ENSG00000143537.14 ADAM15

HGNC:193 ADAM15

KEGG Gene (Homo sapiens):8751 ADAM15

Monarch:8751 ADAM15

NCBI Gene:8751 ADAM15

OMIM:605548 ADAM15

UCSC:Q13444 ADAM15

Reference Transcript

Other Identifiers

11719513_a_at

11745926_a_at

11745927_x_at

11746516_a_at

11755474_a_at

11760450_x_at

1555896_PM_a_at

1555896_a_at

16671579

217007_PM_s_at

217007_s_at

2360577

2360578

2360579

2360581

2360582

2360583

2360584

2360586

2360587

2360588

2360592

2360593

2360595

2360596

2360597

2360598

2360600

2360603

2360604

2360605

2360607

2360608

2360609

2360610

2360611

2360612

2360615

2360618

2360622

2360623

2360624

2360626

2360627

2360628

2360629

2360630

2360632

38282_at

7905881

8751

A_23_P159227

A_33_P3380693

GE59149

GO:0001525

GO:0001669

GO:0001953

GO:0002376

GO:0002418

GO:0003824

GO:0004222

GO:0005178

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0005912

GO:0005929

GO:0006508

GO:0007155

GO:0007160

GO:0007229

GO:0008233

GO:0008237

GO:0008584

GO:0009986

GO:0012505

GO:0016020

GO:0016787

GO:0017124

GO:0022414

GO:0022617

GO:0023052

GO:0030154

GO:0030198

GO:0030308

GO:0030336

GO:0030574

GO:0031410

GO:0031514

GO:0042246

GO:0042995

GO:0043226

GO:0045087

GO:0046872

GO:0048856

GO:0048870

GO:0060317

GO:0070062

GO:0070161

GO:0098542

GO:0140096

GO:1900121

GO:1904628

GO:1990910

HMNXSV003010124

HMNXSV003026996

Hs.92208.1.S1_3p_s_at

ILMN_1751500

ILMN_1756920

ILMN_2384544

PH_hs_0023730

TC01006331.hg

U41767_s_at

Participates

as a member of

Inferred To

ADAM15 [plasma membrane] (Bos taurus)

ADAM15 [plasma membrane] (Canis familiaris)

ADAM15 [plasma membrane] (Drosophila melanogaster)

ADAM15 [plasma membrane] (Gallus gallus)

ADAM15 [plasma membrane] (Mus musculus)

ADAM15 [plasma membrane] (Rattus norvegicus)

ADAM15 [plasma membrane] (Schizosaccharomyces pombe)

ADAM15 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_997077.1, NP_001248395.1, NP_001248393.1, NP_997079.1, NP_997080.1, NP_001248394.1, NP_997078.1, NP_003806.3, NP_997074.1

Guide to Pharmacology - Targets

1661

OpenTargets

ENSG00000143537

GeneCards

Q13444

HPA

ENSG00000143537-ADAM15

Ensembl

ENST00000359280, ENST00000271836, ENSP00000432347, ENSP00000349436, ENST00000360674, ENSP00000432927, ENSP00000476000, ENSP00000348227, ENST00000355956, ENST00000368413, ENST00000368412, ENST00000526491, ENSP00000403843, ENST00000531455, ENSP00000271836, ENST00000356955, ENST00000449910, ENST00000447332, ENSP00000357397, ENSP00000352226, ENSP00000353892, ENSP00000357398, ENSG00000143537, ENST00000529473, ENSP00000434227

PRO

Q13444

Pharos - Targets

Q13444

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P12931 SRC	6	p-Y419-SRC [nucleoplasm] (R-HSA-8937690) SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.75	4
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.713	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.713	4
UniProt:P06239 LCK	4	p-Y394-LCK [plasma membrane] (R-HSA-8857940) p-Y505-LCK [plasma membrane] (R-HSA-202159) p-Y394-LCK [cytosol] (R-HSA-202308) LCK [cytosol] (R-HSA-167609)	0.667	4
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)	0.609	2
UniProt:P06241 FYN	6	p-S21,Y420-FYN [cytosol] (R-HSA-5218745) p-Y531-FYN [cytosol] (R-HSA-391819) MyrG2-PalmC3,6-FYN [plasma membrane] (R-HSA-9606873) p-Y420-FYN [cytosol] (R-HSA-391821) MyrG-p-Y420-FYN [plasma membrane] (R-HSA-1810410) FYN [cytosol] (R-HSA-200917)	0.589	2
UniProt:Q06187 BTK	6	Active BTK [cytosol] (R-HSA-8964323) p-Y223,Y551-BTK [cytosol] (R-HSA-2424454) p-Y551-BTK [cytosol] (R-HSA-2685603) BTK [cytosol] (R-HSA-197948) p-Y551-BTK [plasma membrane] (R-HSA-9606165) p-Y223,Y551-BTK [plasma membrane] (R-HSA-984807)	0.558	2
UniProt:Q8N9N5 BANP	1	BANP [nucleoplasm] (R-HSA-3221973)	0.556	3
UniProt:Q99962 SH3GL2	4	SH3GL2 [cytosol] (R-HSA-182958) SH3GL2 [plasma membrane] (R-HSA-177495) SH3GL2 [clathrin-coated endocytic vesicle membrane] (R-HSA-2130629) SH3GL2 [Golgi membrane] (R-HSA-351189)	0.508	2

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