histidine => urocanate + NH4+

Stable Identifier
R-HSA-70899
Type
Reaction [transition]
Species
Homo sapiens
Compartment
cytosol
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histidine => urocanate + NH4+
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Cytosolic histidine ammonia lyase (HAL) catalyzes the reaction of histidine to form urocanate and NH4+ (Kawai et al. 2005).

Literature References
PubMed ID Title Journal Year
15806399 Molecular characterization of histidinemia: identification of four missense mutations in the histidase gene

Asai, K, Sumi, S, Coleman-Campbell, CM, Morishita, H, Moriyama, A, Kawai, Y, Suchi, M

Hum Genet 2005
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Catalyst Activity

histidine ammonia-lyase activity of HAL [cytosol]

Physical Entity
HAL [cytosol] (Homo sapiens)
Activity
histidine ammonia-lyase activity (GO:0004397)
Orthologous Events
histidine => urocanate + NH4+ (Bos taurus)
histidine => urocanate + NH4+ (Caenorhabditis elegans)
histidine => urocanate + NH4+ (Canis familiaris)
histidine => urocanate + NH4+ (Danio rerio)
histidine => urocanate + NH4+ (Dictyostelium discoideum)
histidine => urocanate + NH4+ (Gallus gallus)
histidine => urocanate + NH4+ (Mus musculus)
histidine => urocanate + NH4+ (Rattus norvegicus)
histidine => urocanate + NH4+ (Sus scrofa)
histidine => urocanate + NH4+ (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2003-06-24)
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