urocanate + H2O => 4-imidazolone-5-propionate

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic urocanate hydratase (UROC1) catalyzes the hydrolysis of urocanate to form 4-imidazolone-5-propanoate. Human UROC1 was first identified in surveys of genes differentially expressed in hepatoblastoma (Yamamda et al. 2004). Recent biochemical and molecular studies of UROC1 protein and cDNA from a patient with urocanic aciduria has confirmed the function of UROC1 in vivo (Espinos et al. 2009).
Literature References
PubMed ID Title Journal Year
19304569 Mutations in the urocanase gene UROC1 are associated with urocanic aciduria

Vilaseca, MA, Palau, F, Espinós, C, Spaapen, LJ, Martinez-Rubio, D, Artuch, R, Ormazabal, A, Lupo, V, Pineda, M

J Med Genet 2009
15221005 Expression profiling and differential screening between hepatoblastomas and the corresponding normal livers: identification of high expression of the PLK1 oncogene as a poor-prognostic indicator of hepatoblastomas

Kaneko, M, Yamada, S, Ohnuma, N, Suita, S, Suzuki, Y, Hirata, T, Nakagawara, A, Horie, H, Ando, H, Ando, K, Sasaki, F, Hayashi, Y, Sugano, S, Goto, T, Takayasu, H, Ohira, M, Matsunaga, T, Hashizume, K, Hiyama, E

Oncogene 2004
Catalyst Activity

urocanate hydratase activity of UROC1:NAD+ [cytosol]

Orthologous Events
Cross References
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