alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+

Stable Identifier
R-HSA-70941
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+
Click the image above or here to open this reaction in the Pathway Browser
The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Alpha-aminoadipic semialdehyde dehydrogenase (ALDH7A1) catalyzes the reaction of alpha-aminoadipic semialdehyde and NAD+ to form alpha-aminoadipate and NADH + H+ (Mills et al. 2006). Unpublished crystallographic data (PDB 2J6L) indicate that the enzyme is a homodimer. Recent immunofluorescence studies of both endogenous and GFP-tagged ALDH7A1 proteins in cultured human embryonic kidney cells indicate that the protein is present in both mitochondria and the cytosol (Wong et al. 2010).
Literature References
PubMed ID Title Journal Year
19885858 Is antiquitin a mitochondrial Enzyme?

Fong, WP, Tang, WK, Wong, JW, Chan, CL, Cheng, CH

J Cell Biochem 2010
16491085 Mutations in antiquitin in individuals with pyridoxine-dependent seizures

Struys, E, Mills, PB, Willemsen, MA, Baumgartner, M, Baxter, P, Uhlenberg, B, Clayton, PT, Weschke, B, Tacke, U, Plecko, B, Jakobs, C, Omran, H

Nat Med 2006
Participants
Input
Output
Participates
as an event of
Catalyst Activity

L-aminoadipate-semialdehyde dehydrogenase activity of ALDH7A1 tetramer [mitochondrial matrix]

Physical Entity
ALDH7A1 tetramer [mitochondrial matrix] (Homo sapiens)
Activity
L-aminoadipate-semialdehyde dehydrogenase activity (GO:0004043)
Orthologous Events
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Bos taurus)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Caenorhabditis elegans)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Canis familiaris)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Danio rerio)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Dictyostelium discoideum)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Drosophila melanogaster)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Gallus gallus)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Mus musculus)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Rattus norvegicus)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Sus scrofa)
alpha-aminoadipoate semialdehyde + NAD+ => alpha-aminoadipate + NADH + H+ (Xenopus tropicalis)
Cross References
Rhea
Authored
D'Eustachio, P  (2003-06-24)
Cite Us!