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IDH3A [mitochondrial matrix]
Stable Identifier
R-HSA-70962
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
mitochondrial matrix
Synonyms
isocitrate dehydrogenase 3 (NAD+) alpha, Isocitrate dehydrogenase (NAD) subunit alpha, mitochondrial precursor, Isocitric dehydrogenase, NAD+-specific ICDH
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Aerobic respiration and respiratory electron transport (Homo sapiens)
Citric acid cycle (TCA cycle) (Homo sapiens)
IDH3 complex decarboxylates isocitrate (Homo sapiens)
IDH3 octamer [mitochondrial matrix] (Homo sapiens)
IDH3 complex [mitochondrial matrix] (Homo sapiens)
IDH3A [mitochondrial matrix] (Homo sapiens)
IDH3A [mitochondrial matrix] (Homo sapiens)
Metabolism of proteins (Homo sapiens)
Mitochondrial protein degradation (Homo sapiens)
CLPXP binds mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
IDH3A [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
IDH3A [mitochondrial matrix] (Homo sapiens)
CLPXP degrades mitochondrial matrix proteins (Homo sapiens)
CLPXP:substrate protein (mitochondrial matrix) [mitochondrial matrix] (Homo sapiens)
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
IDH3A [mitochondrial matrix] (Homo sapiens)
Literature References
PubMed ID
Title
Journal
Year
20435888
Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function
Dange, M
,
Colman, RF
J Biol Chem
2010
External Reference Information
External Reference
UniProt:P50213 IDH3A
Gene Names
IDH3A
Chain
transit peptide:1-27, chain:28-366
Reference Genes
BioGPS Gene:3419 IDH3A
COSMIC (genes):IDH3A IDH3A
CTD Gene:3419 IDH3A
dbSNP Gene:3419 IDH3A
ENSEMBL:ENSG00000166411 IDH3A
HGNC:5384 IDH3A
KEGG:hsa:3419 IDH3A
Monarch:3419 IDH3A
NCBI Gene:3419 IDH3A
OMIM:601149 IDH3A
UCSC:P50213 IDH3A
Reference Transcript
RefSeq:NM_005530.2 IDH3A
Other Identifiers
11737792_a_at
11737793_a_at
11745965_a_at
11749830_a_at
11756565_x_at
16803436
202069_PM_s_at
202069_s_at
202070_PM_s_at
202070_s_at
231137_PM_at
231137_at
3419
3603200
3603201
3603206
3603210
3603211
3603212
3603213
3603214
3603215
3603216
3603217
3603218
3603219
3603220
3603221
3603222
3603223
3603224
3603225
3603226
3603228
3603229
3603231
3603232
3603233
3603234
3603235
3603236
3603237
3603238
3603240
36195_at
7985134
81140_at
A_14_P102928
A_14_P111891
A_14_P127327
A_14_P133899
A_23_P140668
A_24_P167806
GE593140
GE79752
GO:0000287
GO:0003824
GO:0004449
GO:0005515
GO:0005634
GO:0005739
GO:0005759
GO:0005975
GO:0006099
GO:0006102
GO:0016491
GO:0016616
GO:0043226
GO:0045242
GO:0046872
GO:0051287
HMNXSV003037515
Hs.116413.0.A1_3p_at
Hs.250616.0.S1_3p_a_at
ILMN_1698533
PH_hs_0013268
TC15000724.hg
TC15002299.hg
U07681_at
g5031776_3p_a_at
Participates
as a member of
Substrate of CLPXP (mitrochondrial matrix) [mitochondrial matrix] (Homo sapiens)
as a component of
IDH3 complex [mitochondrial matrix] (Homo sapiens)
Inferred To
idh3a [mitochondrial matrix]
(Xenopus tropicalis)
IDH3A [mitochondrial matrix]
(Bos taurus)
IDH3A [mitochondrial matrix]
(Caenorhabditis elegans)
IDH3A [mitochondrial matrix]
(Canis familiaris)
IDH3A [mitochondrial matrix]
(Dictyostelium discoideum)
IDH3A [mitochondrial matrix]
(Drosophila melanogaster)
IDH3A [mitochondrial matrix]
(Mus musculus)
IDH3A [mitochondrial matrix]
(Rattus norvegicus)
IDH3A [mitochondrial matrix]
(Saccharomyces cerevisiae)
IDH3A [mitochondrial matrix]
(Schizosaccharomyces pombe)
IDH3A [mitochondrial matrix]
(Sus scrofa)
Cross References
RefSeq
NP_005521.1
ENSEMBL
ENST00000299518
,
ENSP00000299518
,
ENSG00000166411
OpenTargets
ENSG00000166411
IntEnz
1.1.1.41
GeneCards
IDH3A
HPA
ENSG00000166411-IDH3A
PRO
P50213
Pharos - Targets
P50213
GlyGen
P50213
Orphanet
IDH3A
HMDB Protein
HMDBP00899
PDB
5GRI
,
5GRH
,
8GRD
,
6KE3
,
5YVT
,
6L57
,
7CE3
,
6KDY
,
5GRE
,
8GRG
,
8GRH
,
8GRU
,
5GRL
,
8GS5
,
5GRF
,
8GRB
,
6L59
,
6KDF
,
6KDE
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
7
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