isocitrate + NAD+ => alpha-ketoglutarate + CO2 + NADH + H+ [IDH3]

Stable Identifier
R-HSA-70967
Type
Reaction [transition]
Species
Homo sapiens
Compartment
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Mitochondrial isocitrate dehydrogenase IDH3 catalyzes the irreversible reaction of isocitrate and NAD+ to form alpha ketoglutarate, CO2, and NADH + H+. The enzyme is a heteromer containing four polypeptide chains, two IDH3A, one IDH3B, and one IDH3G, and two Mn++ (Dange and Colman 2010). It is activated by ADP (Soundar et al. 2003, 2006; Bzymek and Colman 2007). This is the first of four oxidation reactions in the citric acid cycle, and the first decarboxylation.

Participants
Participates
Catalyst Activity

isocitrate dehydrogenase (NAD+) activity of IDH3 complex [mitochondrial matrix]

This event is regulated
Positively by
Orthologous Events
Cross References
Rhea
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