Fumarate + H2O <=> (S)-Malate

Stable Identifier
R-HSA-70982
Type
Reaction [transition]
Species
Homo sapiens
Compartment
mitochondrial matrix
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Fumarate + H2O <=> (S)-Malate
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Mitochondrial fumarate hydratase catalyzes the reversible reaction of fumarate and water to form malate, the seventh step of the TCA cycle (Bourgeron et al. 1994). Unpublished crystallographic data indicate that the protein is a tetramer (PDB 3E04).

Literature References
PubMed ID Title Journal Year
8200987 Mutation of the fumarase gene in two siblings with progressive encephalopathy and fumarase deficiency

Chretien, D, Landrieu, P, Doonan, S, Bourgeron, T, Rabier, D, Poggi-Bach, J, Rötig, A, Letouzé, P, Munnich, A, Rustin, P

J Clin Invest 1994
Participants
Input
Output
Participates
as an event of
Catalyst Activity

fumarate hydratase activity of FH tetramer [mitochondrial matrix]

Physical Entity
FH tetramer [mitochondrial matrix] (Homo sapiens)
Activity
fumarate hydratase activity (GO:0004333)
Orthologous Events
fumarate + H2O <=> malate (Gallus gallus)
Fumarate + H2O <=> (S)-Malate (Bos taurus)
Fumarate + H2O <=> (S)-Malate (Caenorhabditis elegans)
Fumarate + H2O <=> (S)-Malate (Canis familiaris)
Fumarate + H2O <=> (S)-Malate (Danio rerio)
Fumarate + H2O <=> (S)-Malate (Dictyostelium discoideum)
Fumarate + H2O <=> (S)-Malate (Drosophila melanogaster)
Fumarate + H2O <=> (S)-Malate (Gallus gallus)
Fumarate + H2O <=> (S)-Malate (Mus musculus)
Fumarate + H2O <=> (S)-Malate (Rattus norvegicus)
Fumarate + H2O <=> (S)-Malate (Saccharomyces cerevisiae)
Fumarate + H2O <=> (S)-Malate (Schizosaccharomyces pombe)
Fumarate + H2O <=> (S)-Malate (Sus scrofa)
Fumarate + H2O <=> (S)-Malate (Xenopus tropicalis)
Cross References
Rhea
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