Reactome | MCEE [mitochondrial matrix]

MCEE [mitochondrial matrix]

Stable Identifier

R-HSA-71012

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

methylmalonyl-CoA epimerase, methylmalonyl-CoA racemase

Locations in the PathwayBrowser for interactor UniProt:P11182 DBT

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Literature References

PubMed ID	Title	Journal	Year
	The Metabolic and Molecular Bases of Inherited Disease, 8th ed Scriver, CR, Beaudet, AL, Valle, D, Sly, WS		2001
11481338	Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome. Bobik, TA, Rasche, ME	J Biol Chem	2001
13934211	Metabolism of propionic acid in animal tissues. IX. Methylmalonyl coenzyme A racemase Mazumder, R, Sasakawa, T, Kaziro, Y, Ochoa, S	J Biol Chem	1962

External Reference Information

External Reference

UniProt:Q96PE7 MCEE

Gene Names

MCEE

Chain

transit peptide:1-36, chain:37-176

Reference Genes

BioGPS Gene:84693 MCEE

COSMIC (genes):MCEE MCEE

CTD Gene:84693 MCEE

dbSNP Gene:84693 MCEE

ENSEMBL:ENSG00000124370 MCEE

HGNC:16732 MCEE

KEGG:hsa:84693 MCEE

Monarch:84693 MCEE

NCBI Gene:84693 MCEE

OMIM:608419 MCEE

UCSC:Q96PE7 MCEE

Reference Transcript

RefSeq:NM_032601.3 MCEE

Other Identifiers

11742736_at

16898890

226238_PM_at

226238_at

2558975

2558977

2558978

2558979

2558980

2558982

2558987

2558989

2558990

2558993

2558994

2558995

2558997

2558998

2558999

2559000

2559001

2559002

55666_at

8052934

84693

A_23_P56654

GE79796

GO:0004493

GO:0005515

GO:0005739

GO:0005759

GO:0006629

GO:0006790

GO:0016853

GO:0019626

GO:0046491

GO:0046872

GO:0055086

HMNXSV003015028

HMNXSV003047492

Hs.94949.0.A1_3p_at

ILMN_1735347

PH_hs_0005189

Inferred To

mcee [mitochondrial matrix] (Danio rerio)

mcee [mitochondrial matrix] (Dictyostelium discoideum)

mcee [mitochondrial matrix] (Xenopus tropicalis)

Mcee [mitochondrial matrix] (Mus musculus)

mce-1 [mitochondrial matrix] (Caenorhabditis elegans)

MCEE [mitochondrial matrix] (Bos taurus)

MCEE [mitochondrial matrix] (Canis familiaris)

MCEE [mitochondrial matrix] (Gallus gallus)

MCEE [mitochondrial matrix] (Rattus norvegicus)

MCEE [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_115990.3

ENSEMBL

ENSG00000124370, ENST00000244217, ENSP00000244217

OpenTargets

ENSG00000124370

IntEnz

5.1.99.1

GeneCards

MCEE

HPA

ENSG00000124370-MCEE

PRO

Q96PE7

Pharos - Targets

Q96PE7

Orphanet

MCEE

HMDB Protein

HMDBP00256

PDB

6QH4, 3RMU

Interactors (8)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q96DZ9-2 CMTM5			0.718	6
UniProt:Q6RW13-2 AGTRAP			0.718	6
UniProt:Q6RW13 AGTRAP	2	AGTRAP(1-159)-p-BRAF(288-545) fusion [cytosol] (R-HSA-6802511) AGTRAP(1-159)-BRAF(288-545) fusion [cytosol] (R-HSA-6802262)	0.666	4
UniProt:Q96DZ9 CKLF5			0.666	4
UniProt:Q9UNK0 STX8			0.556	3
UniProt:P60033 CD81	1	CD81 [plasma membrane] (R-HSA-197933)	0.556	3
UniProt:O75153 CLU			0.527	2
UniProt:P11182 DBT	11	Lipo-K105-DBT [mitochondrial matrix] (R-HSA-70017) Isobutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859151) Isovaleryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859144) 2-Methylbutyryl-lipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859145) LipoH2-K105-DBT [mitochondrial matrix] (R-HSA-9859167) DBT [mitochondrial matrix] (R-HSA-6792584) P276C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865046) S399C Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865036) K313_Y338del Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865051) I98M Lipo-K105-DBT [mitochondrial matrix] (R-HSA-9865057) DBT [cytosol] (R-HSA-9714663)	0.527	3

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