Reactome | TAT deaminates tyrosine

TAT deaminates tyrosine

Stable Identifier

R-HSA-71155

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

Synonyms

2-oxoglutarate + L-tyrosine => 3-(4-hydroxyphenyl)pyruvate + L-glutamate, tyrosine + alpha-ketoglutarate <=> p-hydroxyphenylpyruvate + glutamate

ReviewStatus

5/5

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Cytosolic tyrosine aminotransferase (TAT) catalyzes the reversible reaction of tyrosine and alpha-keto (2-oxo) glutarate to form 3-(4-hydroxyphenyl)pyruvate (HPP, 4-HPPA) and glutamate (Sivaraman & Kirsch, 2006). The enzymatic activity of mouse and rat homologs was also studied (Mitchell et al., 2001; Mehere et al., 2010). Unpublished crystallographic studies (PDB 3DYD) have shown TAT to be a homodimer with a pyridoxal phosphate moiety attached to lysine-280 in each monomer. Mutations in TAT can lead to tyrosinemia type 2 (TYRSN2, MIM:276600; reviewed in Scott, 2006).

Literature References

PubMed ID	Title	Journal	Year
16640556	The narrow substrate specificity of human tyrosine aminotransferase--the enzyme deficient in tyrosinemia type II Sivaraman, S, Kirsch, JF	FEBS J	2006
16602095	The genetic tyrosinemias Scott, CR	Am J Med Genet C Semin Med Genet	2006
	The Metabolic and Molecular Bases of Inherited Disease, 8th ed Scriver, CR, Beaudet, AL, Valle, D, Sly, WS		2001
21153519	Tyrosine aminotransferase: biochemical and structural properties and molecular dynamics simulations Mehere, P, Han, Q, Lemkul, JA, Vavricka, CJ, Robinson, H, Bevan, DR, Li, J	Protein Cell	2010