Reactome | FAH [cytosol]

FAH [cytosol]

Stable Identifier

R-HSA-71174

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

fumarylacetoacetate hydrolase, Fumarylacetoacetase , Fumarylacetoacetate hydrolase, Beta-diketonase

Locations in the PathwayBrowser

Expand all

Metabolism (Homo sapiens)

- Metabolism of amino acids and derivatives (Homo sapiens)
  - Phenylalanine and tyrosine metabolism (Homo sapiens)
    - Tyrosine catabolism (Homo sapiens)
      - FAH cleaves 4FAA (Homo sapiens)
        
        FAH dimer [cytosol] (Homo sapiens)
        
        FAH [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P16930 FAH

Gene Names

FAH

Chain

initiator methionine:, chain:2-419

Reference Genes

BioGPS Gene:2184 FAH

COSMIC (genes):FAH FAH

CTD Gene:2184 FAH

dbSNP Gene:2184 FAH

ENSEMBL:ENSG00000103876 FAH

HGNC:3579 FAH

KEGG:hsa:2184 FAH

Monarch:2184 FAH

NCBI Gene:2184 FAH

OMIM:613871 FAH

UCSC:P16930 FAH

Reference Transcript

RefSeq:NM_000137.2 FAH

Other Identifiers

11717400_a_at

11761712_a_at

16803680

202862_PM_at

202862_at

2184

236481_PM_at

236481_at

3603934

3603935

3603936

3603937

3603938

3603939

3603943

3603944

3603945

3603946

3603947

3603948

3603949

3603950

3603951

3603952

3603953

3603954

3603955

3603956

3603957

3603958

3603959

3603960

3603963

3603964

3603965

3603968

3603969

3603970

36876_at

48002_at

7985268

A_14_P129073

A_23_P129221

GE57969

GE84254

GO:0003824

GO:0004334

GO:0005515

GO:0005829

GO:0006520

GO:0006527

GO:0006559

GO:0006572

GO:0006629

GO:0009072

GO:0016787

GO:0043226

GO:0046872

GO:0070062

GO:1902000

HMNXSV003033611

Hs.18001.0.S1_3p_at

ILMN_1781536

M55150_at

PH_hs_0004222

TC15000747.hg

g4557586_3p_at

Participates

as a component of

FAH dimer [cytosol] (Homo sapiens)

Inferred To

Faa [cytosol] (Drosophila melanogaster)

FAH [cytosol] (Bos taurus)

FAH [cytosol] (Caenorhabditis elegans)

FAH [cytosol] (Canis familiaris)

FAH [cytosol] (Dictyostelium discoideum)

FAH [cytosol] (Gallus gallus)

FAH [cytosol] (Mus musculus)

FAH [cytosol] (Rattus norvegicus)

FAH [cytosol] (Sus scrofa)

fah [cytosol] (Xenopus tropicalis)

Cross References

ENSEMBL

ENST00000561421, ENST00000407106, ENSP00000261755, ENST00000261755, ENSP00000453347, ENSP00000385080

OpenTargets

ENSG00000103876

HPA

ENSG00000103876-FAH

PRO

P16930

Pharos - Targets

P16930

GlyGen

P16930

Orphanet

FAH

HMDB Protein

HMDBP00713

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.553	2

Cite Us!