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TDO2 [cytosol]
Stable Identifier
R-HSA-71184
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
tryptophan 2,3-dioxygenase, tryptophan oxygenase, Tryptophan pyrrolase, Tryptophanase, Tryptophan oxygenase, Tryptamin 2,3-dioxygenase, TRPO
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Tryptophan catabolism (Homo sapiens)
TDO tetramer dioxygenates L-Trp to NFK (Homo sapiens)
TDO2 tetramer [cytosol] (Homo sapiens)
TDO2 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P48775 TDO2
Gene Names
TDO2, TDO
Chain
chain:1-406
Reference Genes
BioGPS Gene:6999 TDO2
COSMIC (genes):TDO2 TDO2
CTD Gene:6999 TDO2
dbSNP Gene:6999 TDO2
ENSEMBL:ENSG00000151790 TDO2
HGNC:11708 TDO2
KEGG:hsa:6999 TDO2
Monarch:6999 TDO2
NCBI Gene:6999 TDO2
OMIM:191070 TDO2
UCSC:P48775 TDO2
Reference Transcript
RefSeq:NM_005651.3 TDO2
Other Identifiers
11755822_a_at
16971758
205943_PM_at
205943_at
2749012
2749013
2749017
2749021
2749022
2749024
2749025
2749026
2749027
2749028
2749030
2749031
2749032
2749033
2749034
2749035
2749036
2749038
2749039
2749040
2749041
2749042
2749045
38606_at
6999
8097991
A_14_P117363
A_23_P80974
GE61964
GO:0003824
GO:0004833
GO:0005515
GO:0005829
GO:0006520
GO:0006568
GO:0006569
GO:0006790
GO:0016491
GO:0016597
GO:0019441
GO:0019442
GO:0019825
GO:0020037
GO:0042802
GO:0046872
GO:0051213
GO:0051289
GO:0055086
GO:0065003
GO:1901135
GO:1904842
HMNXSV003055056
ILMN_1716859
ILMN_2172091
PH_hs_0010828
TC04000789.hg
U32989_at
g5032164_3p_at
Participates
as a component of
TDO2 tetramer [cytosol] (Homo sapiens)
Inferred To
TDO2 [cytosol]
(Bos taurus)
TDO2 [cytosol]
(Caenorhabditis elegans)
TDO2 [cytosol]
(Canis familiaris)
TDO2 [cytosol]
(Danio rerio)
TDO2 [cytosol]
(Dictyostelium discoideum)
TDO2 [cytosol]
(Drosophila melanogaster)
TDO2 [cytosol]
(Gallus gallus)
TDO2 [cytosol]
(Mus musculus)
TDO2 [cytosol]
(Rattus norvegicus)
TDO2 [cytosol]
(Sus scrofa)
TDO2 [cytosol]
(Xenopus tropicalis)
Cross References
Guide to Pharmacology - Targets
2887
ENSEMBL
ENST00000536354
,
ENST00000573403
,
ENSP00000444788
,
ENSP00000460086
OpenTargets
ENSG00000151790
HPA
ENSG00000151790-TDO2
ZINC target
P48775
PRO
P48775
Pharos - Targets
P48775
Orphanet
TDO2
HMDB Protein
HMDBP05537
PDB
5TI9
,
8R5Q
,
8QV7
,
6PYY
,
6PYZ
,
6VBN
,
6UD5
,
7UI3
,
6A4I
,
9EZJ
,
4PW8
,
7LU7
,
5TIA
,
8R5R
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O00560 SDCBP
3
SDCBP [cytosol]
(R-HSA-373639)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [extracellular region]
(R-HSA-6806206)
0.781
7
UniProt:P06730 EIF4E
1
EIF4E [cytosol]
(R-HSA-72578)
0.666
4
UniProt:P12830 CDH1
8
CDH1(155-882) [plasma membrane]
(R-HSA-198003)
CDH1(751-882) [plasma membrane]
(R-HSA-202929)
CDH1(155-750) [plasma membrane]
(R-HSA-202940)
p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8876938)
Ub-K,p-Y753,Y754-CDH1(155-882) [plasma membrane]
(R-HSA-8877002)
CDH1(701-882) [extracellular region]
(R-HSA-2534158)
CDH1(155-700) [plasma membrane]
(R-HSA-2534244)
CDH1(732-882) [plasma membrane]
(R-HSA-3827997)
0.556
3
UniProt:P36957 DLST
5
Lipo-K110-DLST [mitochondrial matrix]
(R-HSA-69993)
SuccinyllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853502)
LipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9853485)
DLST [mitochondrial matrix]
(R-HSA-6792574)
GlutaryllipoH2-K110-DLST [mitochondrial matrix]
(R-HSA-9858581)
0.556
3
UniProt:P27797 CALR
6
CALR [lumenal side of endoplasmic reticulum membrane]
(R-HSA-985502)
CALR [endoplasmic reticulum lumen]
(R-HSA-195905)
CALR [extracellular region]
(R-HSA-2197641)
CALR [endocytic vesicle lumen]
(R-HSA-2239448)
CALR [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-8863866)
CALR [phagocytic vesicle membrane]
(R-HSA-1236879)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P20393 NR1D1
1
NR1D1 [nucleoplasm]
(R-HSA-375499)
0.556
3
UniProt:P25786 PSMA1
2
PSMA1 [cytosol]
(R-HSA-68724)
PSMA1 [nucleoplasm]
(R-HSA-174333)
0.488
2
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