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PXLP-SHMT1 [cytosol]
Stable Identifier
R-HSA-71242
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SHMT1, serine hydroxymethyltransferase, glycine hydroxymethyltransferase, Serine methylase
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of amino acids and derivatives (Homo sapiens)
Carnitine synthesis (Homo sapiens)
SHMT1 tetramer cleaves HTMLYS to yield TEABL and Gly (Homo sapiens)
PXLP-SHMT1 [cytosol] (Homo sapiens)
SHMT1 tetramer [cytosol] (Homo sapiens)
PXLP-SHMT1 [cytosol] (Homo sapiens)
Metabolism of vitamins and cofactors (Homo sapiens)
Metabolism of water-soluble vitamins and cofactors (Homo sapiens)
Metabolism of folate and pterines (Homo sapiens)
5,10-methyleneTHF polyglutamate + glycine <=> tetrahydrofolate polyglutamate (THF polyglutamate) + serine (Homo sapiens)
PXLP-SHMT1 [cytosol] (Homo sapiens)
SHMT1 tetramer [cytosol] (Homo sapiens)
PXLP-SHMT1 [cytosol] (Homo sapiens)
SHMT1 tetramer transfers hydroxymethyl group to THFPG to form 5,10-methylene-THFPG (Homo sapiens)
PXLP-SHMT1 [cytosol] (Homo sapiens)
SHMT1 tetramer [cytosol] (Homo sapiens)
PXLP-SHMT1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P34896 SHMT1
Gene Names
SHMT1
Chain
chain:1-483
Reference Genes
BioGPS Gene:6470 SHMT1
COSMIC (genes):SHMT1 SHMT1
CTD Gene:6470 SHMT1
dbSNP Gene:6470 SHMT1
ENSEMBL:ENSG00000176974 SHMT1
ENSEMBL_homo_sapiens_GENE:ENSG00000176974.21 SHMT1
ENSEMBL_homo_sapiens_GENE:ENSG00000284320.3 SHMT1
HGNC:10850 SHMT1
KEGG Gene (Homo sapiens):6470 SHMT1
Monarch:6470 SHMT1
NCBI Gene:6470 SHMT1
OMIM:182144 SHMT1
UCSC:P34896 SHMT1
Reference Transcript
RefSeq:NM_148918.2 SHMT1
RefSeq:XM_005256767.3 SHMT1
RefSeq:XM_011523992.2 SHMT1
RefSeq:XM_017024957.1 SHMT1
RefSeq:XM_017024958.1 SHMT1
RefSeq:NM_001281786.1 SHMT1
RefSeq:NM_004169.4 SHMT1
Other Identifiers
11733969_a_at
11740366_a_at
11751011_x_at
11756209_x_at
16842103
209980_PM_s_at
209980_s_at
224954_PM_at
224954_at
2409444
2409446
2409449
2409450
34738_at
3748322
3748324
3748325
3748326
3748327
3748330
3748331
3748333
3748334
3748335
3748336
3748338
3748340
3748342
3748347
3748348
3748353
6470
712_s_at
78803_at
8013243
A_23_P502654
A_24_P205364
GE81357
GO:0000900
GO:0003723
GO:0003824
GO:0004372
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0006231
GO:0006520
GO:0006544
GO:0006563
GO:0006565
GO:0006575
GO:0006730
GO:0006766
GO:0008270
GO:0009113
GO:0016740
GO:0017148
GO:0019264
GO:0030170
GO:0035999
GO:0036094
GO:0042802
GO:0042803
GO:0043226
GO:0045182
GO:0046653
GO:0046655
GO:0048027
GO:0051289
GO:0055086
GO:0065003
GO:0070062
GO:0070905
GO:1901135
GO:1904482
GO:1990830
HMNXSV003039652
Hs.8889.1.A2_3p_at
ILMN_1743784
ILMN_1811933
ILMN_2402463
L11931_at
PH_hs_0029657
TC17001201.hg
TC17002528.hg
g438633_3p_a_at
Participates
as a component of
SHMT1 tetramer [cytosol] (Homo sapiens)
Inferred To
mel-32 [cytosol]
(Caenorhabditis elegans)
zgc:77524 [cytosol]
(Danio rerio)
Shmt [cytosol]
(Drosophila melanogaster)
Shmt1 [cytosol]
(Mus musculus)
Shmt1 [cytosol]
(Rattus norvegicus)
SHMT1 [cytosol]
(Bos taurus)
SHMT1 [cytosol]
(Canis familiaris)
SHMT1 [cytosol]
(Sus scrofa)
PXLP-SHMT1 [cytosol]
(Gallus gallus)
PXLP-SHMT1 [cytosol]
(Plasmodium falciparum)
shmt1 [cytosol]
(Dictyostelium discoideum)
shmt1 [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
N6-pyridoxal phosphate-L-lysine at 257
Coordinate
257
PsiMod Name
N6-pyridoxal phosphate-L-lysine [MOD:00128]
PsiMod Definition
A protein modification that effectively converts an L-lysine residue to N6-pyridoxal phosphate-L-lysine.
Cross References
RefSeq
XP_016880447.1
,
XP_011522294.1
,
XP_005256824.1
,
XP_016880446.1
,
NP_004160.3
,
NP_001268715.1
,
NP_683718.1
OpenTargets
ENSG00000176974
IntEnz
2.1.2.1
GeneCards
P34896
HPA
ENSG00000176974-SHMT1
ZINC target
P34896
Ensembl
ENST00000354098
,
ENSG00000284320
,
ENSP00000318868
,
ENST00000640392
,
ENSP00000492715
,
ENSG00000176974
,
ENSP00000318805
,
ENST00000316694
PRO
P34896
Pharos - Targets
P34896
Orphanet
24898
HMDB Protein
HMDBP00794
PDB
7RJL
,
8A11
,
7RJP
,
1BJ4
,
6FL5
,
6M5W
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DMM9 SULT1A3
1
SULT1A3 [cytosol]
(R-HSA-5634741)
0.556
3
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