ribose 5-phosphate + xylulose 5-phosphate <=> sedoheptulose 7-phosphate + D-glyceraldehyde 3-phosphate

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic transketolase (TKT) catalyzes the reversible reaction of D-xylulose 5-phosphate and D-ribose 5-phosphate to form D-glyceraldehyde 3-phosphate and sedoheptulose 7-phosphate. The active transketolase enzyme is a homodimer with one molecule of thiamine pyrophosphate and magnesium bound to each monomer (Wang et al. 1997).

Literature References
PubMed ID Title Journal Year
9357955 Aspartate 155 of human transketolase is essential for thiamine diphosphate-magnesium binding, and cofactor binding is required for dimer formation

Wang, JJ, Martin, PR, Singleton, CK

Biochim Biophys Acta 1997
Event Information
Catalyst Activity

transketolase activity of TKT dimer [cytosol]

Orthologous Events
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