Reactome | 2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate

2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate

Stable Identifier

R-HSA-71445

Type

Reaction [transition]

Species

Homo sapiens

Compartment

cytosol

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2-Phospho-D-glycerate <=> 3-Phospho-D-glycerate

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Cytosolic phosphoglycerate mutase dimer catalyzes the reversible isomerisation of 2- and 3-phosphoglycerate. There are two isoforms of this enzyme, PGAM1 (isoform B) and PGAM2 (isoform M). In the body, erythrocytes express only PGAM1, while skeletal muscle expresses only PGAM2. Other tissues express both isoforms (Repiso et al. 2005; Tsujino et al. 1993).

Literature References

PubMed ID	Title	Journal	Year
8447317	The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency Tsujino, S, Shanske, S, Sakoda, S, Fenichel, G, DiMauro, S	Am J Hum Genet	1993
15710582	Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies Repiso, A, Baso, MJR, Corrons, J-LV, Carreras, J, Climent, F	Haematologica	2005