PGAM dimers (PGAM1,2) isomerise 2PG to 3PG

Stable Identifier
Reaction [transition]
Homo sapiens
2R)-2-phosphoglycerate => (2R)-3-phosphoglycerate
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Cytosolic phosphoglycerate mutase dimers (PGAM1,2) catalyze the reversible isomerisation of 2- and 3-phosphoglycerate (2PG; 3PG). There are two isoforms of this enzyme, PGAM1 (isoform B) and PGAM2 (isoform M). In the body, erythrocytes express only PGAM1, while skeletal muscle expresses only PGAM2. Other tissues express both isoforms (Omenn & Cheung 1974; Repiso et al. 2005; Tsujino et al. 1993).

Literature References
PubMed ID Title Journal Year
4827367 Phosphoglycerate mutase isozyme marker for tissue differentiation in man

Omenn, GS, Cheung, SC

Am J Hum Genet 1974
15710582 Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies

Baso, MJR, Repiso, A, Climent, F, Corrons, J-LV, Carreras, J

Haematologica 2005
8447317 The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency

Fenichel, G, Sakoda, S, Tsujino, S, DiMauro, S, Shanske, S

Am J Hum Genet 1993
Catalyst Activity

phosphoglycerate mutase activity of PGAM dimers [cytosol]

Orthologous Events
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