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ALDOA [cytosol]
Stable Identifier
R-HSA-71492
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Fructose-bisphosphate aldolase A , Muscle-type aldolase, Lung cancer antigen NY-LU-1
Locations in the PathwayBrowser
Expand all
Metabolism (Homo sapiens)
Metabolism of carbohydrates (Homo sapiens)
Glucose metabolism (Homo sapiens)
Gluconeogenesis (Homo sapiens)
Aldolase tetramers convert GA3P and DHAP to F1,6PP (Homo sapiens)
aldolase tetramer [cytosol] (Homo sapiens)
fructose-bisphosphate aldolase A, class I holoenzyme [cytosol] (Homo sapiens)
ALDOA [cytosol] (Homo sapiens)
Glycolysis (Homo sapiens)
D-fructose 1,6-bisphosphate <=> dihydroxyacetone phosphate + D-glyceraldehyde 3-phosphate (Homo sapiens)
aldolase tetramer [cytosol] (Homo sapiens)
fructose-bisphosphate aldolase A, class I holoenzyme [cytosol] (Homo sapiens)
ALDOA [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P04075 ALDOA
Gene Names
ALDOA, ALDA
Chain
initiator methionine:, chain:2-364
Reference Genes
BioGPS Gene:226 ALDOA
COSMIC (genes):ALDOA ALDOA
CTD Gene:226 ALDOA
dbSNP Gene:226 ALDOA
ENSEMBL:ENSG00000149925 ALDOA
ENSEMBL_homo_sapiens_GENE:ENSG00000149925.22 ALDOA
HGNC:414 ALDOA
KEGG Gene (Homo sapiens):226 ALDOA
Monarch:226 ALDOA
NCBI Gene:226 ALDOA
OMIM:103850 ALDOA
UCSC:P04075 ALDOA
Reference Transcript
RefSeq:NM_001243177.1 ALDOA
RefSeq:XM_011545768.2 ALDOA
RefSeq:NM_184041.2 ALDOA
RefSeq:NM_184043.2 ALDOA
RefSeq:NM_000034.3 ALDOA
RefSeq:NM_001127617.2 ALDOA
Other Identifiers
11733097_x_at
11745964_x_at
16817790
200966_PM_x_at
200966_x_at
214687_PM_x_at
214687_x_at
226
32336_at
3311650
3655930
3655931
3655932
3655933
3655936
3655937
3655938
3655940
3655943
3655944
3655945
3655948
3655951
3655953
3655954
3655955
3655956
7994737
86570_f_at
A_23_P88963
A_24_P921584
GE59667
GO:0003012
GO:0003723
GO:0003779
GO:0003824
GO:0004332
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005737
GO:0005829
GO:0005856
GO:0005975
GO:0006000
GO:0006091
GO:0006096
GO:0006754
GO:0006941
GO:0007010
GO:0007015
GO:0007339
GO:0008092
GO:0008360
GO:0015629
GO:0015631
GO:0016020
GO:0016829
GO:0022414
GO:0030388
GO:0031093
GO:0031410
GO:0031430
GO:0031674
GO:0034774
GO:0042802
GO:0043226
GO:0045296
GO:0046716
GO:0048856
GO:0051289
GO:0055086
GO:0061827
GO:0065003
GO:0070061
GO:0070062
GO:1901135
GO:1904724
GO:1904813
HMNXSV003025296
Hs.273415.1.S1_3p_x_at
ILMN_1681374
ILMN_1736700
ILMN_1741148
ILMN_2251253
PH_hs_0028065
X12447_at
Participates
as a component of
fructose-bisphosphate aldolase A, class I holoenzyme [cytosol] (Homo sapiens)
Other forms of this molecule
ALDOA [platelet alpha granule lumen]
ALDOA [secretory granule lumen]
ALDOA [ficolin-1-rich granule lumen]
ALDOA [extracellular region]
ALDOA [tertiary granule lumen]
Inferred To
Ald2 [cytosol]
(Drosophila melanogaster)
aldoaa [cytosol]
(Danio rerio)
aldoa [cytosol]
(Xenopus tropicalis)
ALDOB [cytosol]
(Caenorhabditis elegans)
ALDOB [cytosol]
(Dictyostelium discoideum)
ALDOB [cytosol]
(Drosophila melanogaster)
ALDOB [cytosol]
(Plasmodium falciparum)
Homologues of ALDOA [cytosol]
(Caenorhabditis elegans)
Homologues of ALDOA [cytosol]
(Drosophila melanogaster)
ALDOA [cytosol]
(Bos taurus)
ALDOA [cytosol]
(Caenorhabditis elegans)
ALDOA [cytosol]
(Canis familiaris)
ALDOA [cytosol]
(Mus musculus)
ALDOA [cytosol]
(Rattus norvegicus)
ALDOA [cytosol]
(Sus scrofa)
Cross References
RefSeq
XP_011544070.1
,
NP_908932.1
,
NP_001121089.1
,
NP_908930.1
,
NP_001230106.1
,
NP_000025.1
OpenTargets
ENSG00000149925
IntEnz
4.1.2.13
GeneCards
P04075
HPA
ENSG00000149925-ALDOA
Ensembl
ENSP00000400452
,
ENST00000563060
,
ENST00000642816
,
ENST00000412304
,
ENSP00000455700
,
ENSG00000149925
,
ENSP00000455800
,
ENSP00000496166
,
ENST00000643777
,
ENSP00000494188
,
ENST00000569545
PRO
P04075
Pharos - Targets
P04075
Orphanet
15491
HMDB Protein
HMDBP00978
PDB
6XMO
,
1ALD
,
4ALD
,
6XMH
,
6XMM
,
2ALD
,
6XML
,
5KY6
Interactors (6)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
18
UniProt:P12004 PCNA
5
monoSUMO1-K164,K254,K-PCNA [nucleoplasm]
(R-HSA-4615861)
K63polyUb-K164-PCNA [nucleoplasm]
(R-HSA-8943000)
ISG-K164,ISG-K168-PCNA [nucleoplasm]
(R-HSA-5653768)
MonoUb-K164-PCNA [nucleoplasm]
(R-HSA-5651986)
PCNA [nucleoplasm]
(R-HSA-68439)
0.571
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.569
10
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.553
2
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:Q86X55 CARM1
1
CARM1 [nucleoplasm]
(R-HSA-400139)
0.499
2
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