3-Phospho-D-glycerate <=> 2-Phospho-D-glycerate

Stable Identifier
Reaction [transition]
Homo sapiens
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Cytosolic phosphoglycerate mutase catalyzes the reversible isomerisation of 3- and 2-phosphoglycerate. The active form of the enzyme is a dimer. There are two isoforms of this enzyme, PGAM1 (isoform B, widely expressed in non-muscle tissue) and PGAM2 (isoform M, expressed in muscle) (Blouquit et al. 1988; Omenn and Cheung 1974; Repiso et al. 2005; Tsujino et al. 1993).
Literature References
PubMed ID Title Journal Year
4827367 Phosphoglycerate mutase isozyme marker for tissue differentiation in man

Omenn, GS, Cheung, SC

Am J Hum Genet 1974
15710582 Phosphoglycerate mutase BB isoenzyme deficiency in a patient with non-spherocytic anemia: familial and metabolic studies

Baso, MJR, Repiso, A, Climent, F, Corrons, J-LV, Carreras, J

Haematologica 2005
2846554 Sequence of the human erythrocyte phosphoglycerate mutase by microsequencer and mass spectrometry

Calvin, MC, Prome, JC, Rosa, R, Cohen-Solal, M, Prome, D, Blouquit, Y, Rosa, J, Pratbernou, F

J Biol Chem 1988
8447317 The molecular genetic basis of muscle phosphoglycerate mutase (PGAM) deficiency

Fenichel, G, Sakoda, S, Tsujino, S, DiMauro, S, Shanske, S

Am J Hum Genet 1993
Event Information
Catalyst Activity

phosphoglycerate mutase activity of PGAM dimers [cytosol]

Orthologous Events
Cross References
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