Reactome | EFTUD2 [nucleoplasm]

EFTUD2 [nucleoplasm]

Stable Identifier

R-HSA-71883

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U5-116 kDa protein, U5S1_HUMAN, 116 kDa U5 small nuclear ribonucleoprotein component (U5 snRNP- specific protein, 116 kDa) (U5-116 kDa), 116 kDa U5 small nuclear ribonucleoprotein component, U5 snRNP- specific protein, 116 kDa, U5-116 kDa

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15029 EFTUD2

Gene Names

EFTUD2, KIAA0031, SNRP116

Chain

chain:1-972

Reference Genes

BioGPS Gene:9343 EFTUD2

COSMIC (genes):EFTUD2 EFTUD2

CTD Gene:9343 EFTUD2

dbSNP Gene:9343 EFTUD2

ENSEMBL:ENSG00000108883 EFTUD2

HGNC:30858 EFTUD2

KEGG:hsa:9343 EFTUD2

Monarch:9343 EFTUD2

NCBI Gene:9343 EFTUD2

OMIM:603892 EFTUD2

UCSC:Q15029 EFTUD2

Reference Transcript

Other Identifiers

11716057_a_at

11716058_a_at

11716059_x_at

11740353_a_at

11740354_a_at

11758740_at

16845742

222397_PM_at

222397_at

222398_PM_s_at

222398_s_at

3759358

3759359

3759360

3759361

3759362

3759364

3759366

3759367

3759368

3759369

3759370

3759371

3759372

3759373

3759374

3759375

3759376

3759377

3759378

3759379

3759380

3759381

3759382

3759384

3759385

3759386

3759389

3759390

3759392

3759393

3759394

3759395

3759396

3759397

3759398

3759399

3759400

3759401

3759402

3759403

3759404

3759405

3759406

3759407

3759408

3759409

8016099

9343

A_23_P55190

D21163_at

GE57110

GO:0000398

GO:0003723

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005634

GO:0005654

GO:0005681

GO:0005829

GO:0006397

GO:0008380

GO:0015030

GO:0016020

GO:0016071

GO:0016607

GO:0016787

GO:0030623

GO:0042220

GO:0043226

GO:0043231

GO:0046540

GO:0071005

GO:0071007

GO:0071013

GO:0071466

HMNXSV003035382

Hs.151787.0.S3_3p_at

ILMN_1738819

PH_hs_0031865

PH_hs_0038658

TC17001586.hg

g12803112_3p_a_at

Participates

as a component of

Inferred To

Dmel\CG4849 [nucleoplasm] (Drosophila melanogaster)

eftu-2 [nucleoplasm] (Caenorhabditis elegans)

eftud2 [nucleoplasm] (Danio rerio)

eftud2 [nucleoplasm] (Dictyostelium discoideum)

eftud2 [nucleoplasm] (Xenopus tropicalis)

EFTUD2 [nucleoplasm] (Bos taurus)

EFTUD2 [nucleoplasm] (Canis familiaris)

EFTUD2 [nucleoplasm] (Gallus gallus)

EFTUD2 [nucleoplasm] (Mus musculus)

EFTUD2 [nucleoplasm] (Plasmodium falciparum)

EFTUD2 [nucleoplasm] (Schizosaccharomyces pombe)

EFTUD2 [nucleoplasm] (Sus scrofa)

Eftud2 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_001245282.1, NP_001245283.1, NP_004238.3, NP_001136077.1

OpenTargets

ENSG00000108883

ENSEMBL

ENST00000591382, ENST00000402521, ENSP00000465058, ENSP00000385873, ENST00000426333, ENSP00000467805, ENST00000592576, ENSP00000392094

HPA

ENSG00000108883-EFTUD2

PRO

Q15029

Pharos - Targets

Q15029

Orphanet

EFTUD2

GlyGen

Q15029

HMDB Protein

HMDBP08614

PDB

6ICZ, 8R09, 6QW6, 8R0A, 8RM5, 7ABG, 8R0B, 7ABI, 5Z56, 8CH6, 7W5B, 8H6E, 5Z57, 6ID1, 5O9Z, 8QP8, 8Q7Q, 8QPE, 6ID0, 8R08, 8QXD, 8QPB, 8Q7V, 5Z58, 8H6L, 8H6J, 7AAV, 8Q91, 7QTT, 5YZG, 6AHD, 8QZS, 8QO9, 8Q7W, 8QPK, 7W59, 3JCR, 7W5A, 6QDV, 8Y6O, 7ABF, 5XJC, 6FF7, 8QPA, 8QOZ, 8QP9, 6QX9, 6FF4, 8Q7X, 5MQF, 8Q7N, 8RC0, 8H6K, 7DVQ, 8C6J, 6AH0, 6ZYM

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O94906 PRPF6	1	PRPF6 [nucleoplasm] (R-HSA-71881)	0.838	7
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.706	5
UniProt:Q9BUQ8 DDX23	1	DDX23 [nucleoplasm] (R-HSA-71879)	0.706	5
UniProt:P01106 MYC	2	MYC [nucleoplasm] (R-HSA-188379) PolyUb-MYC [nucleoplasm] (R-HSA-6783169)	0.677	6
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.669	3
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.643	5
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.643	5
UniProt:Q13123 IK	1	IK [nucleoplasm] (R-HSA-9770239)	0.618	3
UniProt:Q53GS9 USP39	1	USP39 [nucleoplasm] (R-HSA-6806793)	0.615	3
UniProt:Q13523 PRPF4B	1	PRPF4B [nucleoplasm] (R-HSA-9769525)	0.527	2
UniProt:P83876 TXNL4A	1	TXNL4A [nucleoplasm] (R-HSA-71875)	0.527	2
UniProt:P11387 TOP1	2	TOP1 [nucleoplasm] (R-HSA-4641363) monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364)	0.527	2
UniProt:P04792 HSBP1	3	HSPB1 [cytosol] (R-HSA-450563) p-S15,S78,S82-HSP27 [cytosol] (R-HSA-5218697) p-S78,S82 HSPB1 [cytosol] (R-HSA-5687009)	0.508	2
UniProt:Q00613 HSF1	11	HSF1 [cytosol] (R-HSA-3371452) p-S326-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082355) hC36,103-HSF1 [nucleoplasm] (R-HSA-3371416) Ac-K80-hC36,103-HSF1 [nucleoplasm] (R-HSA-5097238) p-S230-hC36,103-HSF1 [nucleoplasm] (R-HSA-5082361) hC36,103-HSF1 [cytosol] (R-HSA-4793916) HSF1 [nucleoplasm] (R-HSA-5082385) p-S303,307-HSF1 [cytosol] (R-HSA-4793922) p-S307-HSF1 [cytosol] (R-HSA-4793929) p-S303-HSF1 [cytosol] (R-HSA-4793927) p-S121-HSF1 [cytosol] (R-HSA-4793906)	0.508	2
UniProt:Q9H9Z2 LIN28A	1	LIN28A [cytosol] (R-HSA-500391)	0.504	4
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.483	2
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.483	2
UniProt:Q9Y265 RUVBL1	1	RUVBL1 [nucleoplasm] (R-HSA-418323)	0.483	2
UniProt:Q9Y230 RUVBL2	1	RUVBL2 [nucleoplasm] (R-HSA-418321)	0.483	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6
UniProt:Q9NZ63 C9orf78	1	C9orf78 [nucleoplasm] (R-HSA-9769588)	0.483	2
UniProt:Q9BRR8 GPATCH1	1	GPATCH1 [nucleoplasm] (R-HSA-9770419)	0.483	3

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