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SNRNP70 [nucleoplasm]
Stable Identifier
R-HSA-71913
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
U1 - 70K protein, RU17_HUMAN, U1 small nuclear ribonucleoprotein 70 kDa, U1 snRNP 70 kDa, snRNP70, U1-70K
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
U1 snRNP [nucleoplasm] (Homo sapiens)
SNRNP70 [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
U1 snRNP [nucleoplasm] (Homo sapiens)
SNRNP70 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
U1 snRNP [nucleoplasm] (Homo sapiens)
SNRNP70 [nucleoplasm] (Homo sapiens)
U1 snRNP [nucleoplasm] (Homo sapiens)
SNRNP70 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
U1 snRNP [nucleoplasm] (Homo sapiens)
SNRNP70 [nucleoplasm] (Homo sapiens)
U1 snRNP [nucleoplasm] (Homo sapiens)
SNRNP70 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
U1 snRNP [nucleoplasm] (Homo sapiens)
SNRNP70 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
U1 snRNP [nucleoplasm] (Homo sapiens)
SNRNP70 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P08621 SNRNP70
Gene Names
SNRNP70, RNPU1Z, RPU1, SNRP70, U1AP1
Chain
initiator methionine:, chain:2-437
Reference Genes
BioGPS Gene:6625 SNRNP70
COSMIC (genes):SNRNP70 SNRNP70
CTD Gene:6625 SNRNP70
dbSNP Gene:6625 SNRNP70
ENSEMBL:ENSG00000104852 SNRNP70
ENSEMBL_homo_sapiens_GENE:ENSG00000104852.15 SNRNP70
HGNC:11150 SNRNP70
KEGG Gene (Homo sapiens):6625 SNRNP70
Monarch:6625 SNRNP70
NCBI Gene:6625 SNRNP70
OMIM:180740 SNRNP70
UCSC:P08621 SNRNP70
Reference Transcript
RefSeq:NM_001301069.1 SNRNP70
RefSeq:NM_003089.5 SNRNP70
Other Identifiers
11754463_a_at
11755283_a_at
16863974
201221_PM_s_at
201221_s_at
3838186
3838187
3838190
3838192
3838194
3838198
3838199
3838203
3838207
3838208
3838209
3838210
3838211
3838212
3838213
3838218
3838222
3838223
3838224
3838225
3838226
3838227
3838228
3838237
40875_s_at
6625
8030199
87370_at
A_23_P4902
A_23_P4909
GE79537
GO:0000398
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005634
GO:0005654
GO:0005681
GO:0005685
GO:0006397
GO:0006457
GO:0006914
GO:0016071
GO:0016607
GO:0030163
GO:0030619
GO:0043226
GO:0043462
GO:0043484
GO:0048026
GO:0061084
GO:0071004
GO:1904715
GO:1990904
HMNXSV003024985
ILMN_1683049
ILMN_1732053
ILMN_2380839
PH_hs_0010437
TC19000724.hg
TC19002196.hg
TC19002197.hg
X04654_s_at
g4507118_3p_a_at
g4507118_3p_s_at
Participates
as a component of
U1 snRNP [nucleoplasm] (Homo sapiens)
Inferred To
Ghost homologue of SNRNP70 [nucleoplasm]
(Gallus gallus)
Snrnp70 [nucleoplasm]
(Mus musculus)
Snrnp70 [nucleoplasm]
(Rattus norvegicus)
snrp70 [nucleoplasm]
(Danio rerio)
snrnp70 [nucleoplasm]
(Dictyostelium discoideum)
snrnp70 [nucleoplasm]
(Xenopus tropicalis)
usp101 [nucleoplasm]
(Schizosaccharomyces pombe)
SNP1 [nucleoplasm]
(Saccharomyces cerevisiae)
SNRNP70 [nucleoplasm]
(Bos taurus)
SNRNP70 [nucleoplasm]
(Canis familiaris)
SNRNP70 [nucleoplasm]
(Plasmodium falciparum)
SNRNP70 [nucleoplasm]
(Sus scrofa)
snRNP-U1-70K [nucleoplasm]
(Drosophila melanogaster)
rnp-7 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_001287998.1
,
NP_003080.2
OpenTargets
ENSG00000104852
GeneCards
P08621
HPA
ENSG00000104852-SNRNP70
Ensembl
ENST00000595231
,
ENSG00000104852
,
ENSP00000471006
,
ENSP00000385077
,
ENST00000598441
,
ENSP00000468952
,
ENST00000221448
,
ENSP00000472998
,
ENST00000601065
,
ENSP00000221448
,
ENST00000401730
PRO
P08621
Pharos - Targets
P08621
Orphanet
24932
PDB
2L5I
,
3CW1
,
6QX9
,
7VPX
,
3PGW
,
2L5J
,
7B0Y
,
4PKD
,
4PJO
Interactors (9)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P14678 SNRPB
4
Me2-R108,R112-SNRPB [nucleoplasm]
(R-HSA-192213)
SNRPB [nucleoplasm]
(R-HSA-71896)
SNRPB [cytosol]
(R-HSA-191798)
2xMe-SNRPB [cytosol]
(R-HSA-192218)
0.641
4
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
3
UniProt:P62306 SNRPF
2
SNRPF [nucleoplasm]
(R-HSA-71907)
SNRPF [cytosol]
(R-HSA-191852)
0.527
3
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
UniProt:P62316 SNRPD2
2
SNRPD2 [nucleoplasm]
(R-HSA-71901)
SNRPD2 [cytosol]
(R-HSA-191810)
0.527
3
UniProt:P62318 SNRPD3
3
2xMe-SNRPD3 [nucleoplasm]
(R-HSA-192219)
SNRPD3 [nucleoplasm]
(R-HSA-71903)
2xMe-SNRPD3 [cytosol]
(R-HSA-191781)
0.527
3
UniProt:P62304 SNRPE
2
SNRPE [nucleoplasm]
(R-HSA-71905)
SNRPE [cytosol]
(R-HSA-191782)
0.527
3
UniProt:P62314 SNRPD1
3
2xMe-SNRPD1 [nucleoplasm]
(R-HSA-192215)
SNRPD1 [cytosol]
(R-HSA-191890)
2xMe-SNRPD1 [cytosol]
(R-HSA-192217)
0.527
3
UniProt:Q07955 SRSF1
1
SRSF1 [nucleoplasm]
(R-HSA-72031)
0.471
3
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