Reactome | PCBP1 [nucleoplasm]

PCBP1 [nucleoplasm]

Stable Identifier

R-HSA-71919

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hnRNP-E1, PCB1_HUMAN, Poly(rC)-binding protein 1, Alpha-CP1, Nucleic acid binding protein SUB2.3

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15365 PCBP1

Gene Names

PCBP1

Chain

chain:1-356

Reference Genes

BioGPS Gene:5093 PCBP1

COSMIC (genes):PCBP1 PCBP1

CTD Gene:5093 PCBP1

dbSNP Gene:5093 PCBP1

ENSEMBL:ENSG00000169564 PCBP1

HGNC:8647 PCBP1

KEGG:hsa:5093 PCBP1

Monarch:5093 PCBP1

NCBI Gene:5093 PCBP1

OMIM:601209 PCBP1

UCSC:Q15365 PCBP1

Reference Transcript

RefSeq:NM_006196.3 PCBP1

Other Identifiers

11758107_x_at

16881153

208620_PM_at

208620_at

2487640

2487641

2487642

2487643

2487644

2487645

2487646

3416066

34305_at

5093

8042515

A_14_P103385

A_23_P68040

A_24_P103025

GE81608

GO:0000981

GO:0003676

GO:0003677

GO:0003697

GO:0003723

GO:0003729

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0014069

GO:0016020

GO:0016607

GO:0036464

GO:0039694

GO:0043226

GO:0045296

GO:0045944

GO:0070062

GO:0098847

GO:0140110

GO:1990904

HMNXSV003058173

ILMN_1673215

PH_hs_0028716

PH_hs_0030894

TC02000414.hg

Z29505_at

g1215670_3p_at

Participates

as a component of

hnRNP proteins [nucleoplasm] (Homo sapiens)

as a member of

Alternative Splicing Factors [nucleoplasm] (Homo sapiens)

Inferred To

PCBP1 [nucleoplasm] (Bos taurus)

PCBP1 [nucleoplasm] (Canis familiaris)

PCBP1 [nucleoplasm] (Plasmodium falciparum)

PCBP1 [nucleoplasm] (Sus scrofa)

Pcbp1 [nucleoplasm] (Mus musculus)

Pcbp1 [nucleoplasm] (Rattus norvegicus)

pcbp2 [nucleoplasm] (Danio rerio)

pes-4 [nucleoplasm] (Caenorhabditis elegans)

pcbp3 [nucleoplasm] (Xenopus tropicalis)

mub [nucleoplasm] (Drosophila melanogaster)

usp108 [nucleoplasm] (Schizosaccharomyces pombe)

Cross References

ENSEMBL

ENSG00000169564, ENST00000303577, ENSP00000305556

OpenTargets

ENSG00000169564

GeneCards

PCBP1

HPA

ENSG00000169564-PCBP1

PRO

Q15365

Pharos - Targets

Q15365

GlyGen

Q15365

PDB

3VKE, 1ZTG, 1WVN

Interactors (13)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.569	5
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.564	3
UniProt:O00425 IGF2BP3	1	IGF2BP3 [cytosol] (R-HSA-428313)	0.556	3
UniProt:P42336 PIK3CA	20	PIK3CA H1047L [cytosol] (R-HSA-1500714) PIK3CA H1047R [cytosol] (R-HSA-1500716) PIK3CA [cytosol] (R-HSA-74787) PIK3CA R38C [cytosol] (R-HSA-1500691) PIK3CA R38G [cytosol] (R-HSA-2395950) PIK3CA R38S [cytosol] (R-HSA-2395947) PIK3CA R38H [cytosol] (R-HSA-1500718) PIK3CA E542Q [cytosol] (R-HSA-2328003) PIK3CA Q546P [cytosol] (R-HSA-1500695) PIK3CA Q546R [cytosol] (R-HSA-2362373) PIK3CA Q546H [cytosol] (R-HSA-2362374) PIK3CA E545G [cytosol] (R-HSA-1500709) PIK3CA Q546L [cytosol] (R-HSA-2362375) PIK3CA E542V [cytosol] (R-HSA-2328074) PIK3CA E545V [cytosol] (R-HSA-2362365) PIK3CA Q546E [cytosol] (R-HSA-2362383) PIK3CA E545Q [cytosol] (R-HSA-2362362) PIK3CA E545K [cytosol] (R-HSA-1500706) PIK3CA E545A [cytosol] (R-HSA-2362355) PIK3CA Q546K [cytosol] (R-HSA-1500705)	0.527	2
UniProt:P08581 MET	7	p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-6806973) MET [plasma membrane] (R-HSA-419603) p-Y1003,4Y-MET [plasma membrane] (R-HSA-8874689) MonoUb-K,p-Y1003,4Y-MET [plasma membrane] (R-HSA-8875180) MonoUb-K,p-Y1234,Y1235,Y1349,Y1356-MET [plasma membrane] (R-HSA-8875181) p-Y1234,Y1235,Y1356-MET [plasma membrane] (R-HSA-6807014) p-Y1349,Y1356-MET [plasma membrane] (R-HSA-6807032)	0.527	2
UniProt:P11940 PABPC1	1	PABPC1 [cytosol] (R-HSA-156803)	0.527	2
UniProt:P42685 FRK	4	FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235) FRK [azurophil granule lumen] (R-HSA-6799142) p-Y387-FRK [cytosol] (R-HSA-8847965)	0.527	2
UniProt:Q13153 PAK1	5	p-S144,T423-PAK1 [cytosol] (R-HSA-399819) PAK1 [cytosol] (R-HSA-162629) Active PAK1 [cytosol] (R-HSA-8964622) p-S144,T423-PAK1 [plasma membrane] (R-HSA-3928472) PAK1 [plasma membrane] (R-HSA-3928409)	0.524	2
UniProt:Q9Y2W2 WBP11	1	WBP11 [nucleoplasm] (R-HSA-8867887)	0.508	2
UniProt:Q15366 PCBP2	2	PCBP2 [cytosol] (R-HSA-983457) PCBP2 [nucleoplasm] (R-HSA-71921)	0.508	2
UniProt:Q13427 PPIG	2	PPIG [nucleoplasm] (R-HSA-9769592) PPIG [cytosol] (R-HSA-9728768)	0.508	2
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	13

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