Reactome | PTBP1 [nucleoplasm]

PTBP1 [nucleoplasm]

Stable Identifier

R-HSA-71923

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hnRNP I, PTB_HUMAN, Polypyrimidine tract-binding protein 1, PTB, Heterogeneous nuclear ribonucleoprotein I, 57 kDa RNA-binding protein PPTB-1

Locations in the PathwayBrowser for interactor UniProt:Q96PU8 QKI

Expand all

External Reference Information

External Reference

UniProt:P26599 PTBP1

Gene Names

PTBP1, PTB

Chain

chain:1-557

Reference Genes

BioGPS Gene:5725 PTBP1

COSMIC (genes):PTBP1 PTBP1

CTD Gene:5725 PTBP1

dbSNP Gene:5725 PTBP1

ENSEMBL:ENSG00000011304 PTBP1

ENSEMBL_homo_sapiens_GENE:ENSG00000011304.22 PTBP1

HGNC:9583 PTBP1

KEGG Gene (Homo sapiens):5725 PTBP1

Monarch:5725 PTBP1

NCBI Gene:5725 PTBP1

OMIM:600693 PTBP1

UCSC:P26599 PTBP1

Reference Transcript

Other Identifiers

11742456_a_at

11742457_s_at

11742677_x_at

11742678_s_at

16856257

16856273

202189_PM_x_at

202189_x_at

211270_PM_x_at

211270_x_at

211271_PM_x_at

211271_x_at

212015_PM_x_at

212015_x_at

212016_3p_s_at

212016_PM_s_at

212016_s_at

216306_PM_x_at

216306_x_at

3815167

3815169

3815170

3815171

3815172

3815174

3815176

3815178

3815179

3815181

3815183

3815188

3815192

3815193

3815194

3815195

3815196

3815197

3815198

3815199

3815200

3815201

3815202

3815203

40593_at

5725

8024019

A_14_P138892

A_24_P14367

GE59935

GE87923

GO:0000381

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005730

GO:0006351

GO:0006355

GO:0006397

GO:0008187

GO:0008380

GO:0010467

GO:0016020

GO:0016071

GO:0022008

GO:0023052

GO:0030154

GO:0033119

GO:0035307

GO:0036002

GO:0036211

GO:0043226

GO:0043484

GO:0045595

GO:0045665

GO:0045944

GO:0048025

GO:0048856

GO:0051148

GO:0070062

GO:0070886

GO:0075522

HMNXSV003020025

HMNXSV003036042

Hs.172550.3.S1_3p_a_at

Hs.172550.3.S1_3p_x_at

Hs.172550.6.A1_3p_a_at

ILMN_1655154

ILMN_2333319

PH_hs_0010319

TC19000015.hg

TC19000016.hg

g13325139_3p_a_at

g4506242_3p_x_at

p8489

Participates

as a component of

as a member of

Alternative Splicing Factors [nucleoplasm] (Homo sapiens)

as an input of

PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)

Inferred To

PTBP1 [nucleoplasm] (Bos taurus)

PTBP1 [nucleoplasm] (Canis familiaris)

PTBP1 [nucleoplasm] (Dictyostelium discoideum)

PTBP1 [nucleoplasm] (Gallus gallus)

PTBP1 [nucleoplasm] (Plasmodium falciparum)

PTBP1 [nucleoplasm] (Sus scrofa)

ptb-1 [nucleoplasm] (Caenorhabditis elegans)

ptbp1 [nucleoplasm] (Xenopus tropicalis)

Ptbp1 [nucleoplasm] (Mus musculus)

Ptbp1 [nucleoplasm] (Rattus norvegicus)

ptbp1a [nucleoplasm] (Danio rerio)

heph [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_002810.1, NP_114368.1, NP_114367.1

OpenTargets

ENSG00000011304

HPA

ENSG00000011304-PTBP1

GeneCards

P26599

Ensembl

ENSP00000408096, ENSP00000349428, ENST00000349038, ENSP00000014112, ENST00000356948, ENSG00000011304, ENST00000394601

PRO

P26599

Pharos - Targets

P26599

PDB

1SJQ, 2AD9, 1QM9, 8BWF, 2ADC, 2ADB, 1SJR, 3ZZZ, 2EVZ, 3ZZY, 2N3O, 8BGF

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.8	7
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.749	13
UniProt:P23246 SFPQ	3	SFPQ [cytosol] (R-HSA-9635505) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [nucleoplasm] (R-HSA-3900138)	0.702	4
UniProt:P98175 RBM10	1	RBM10 [nucleoplasm] (R-HSA-9770262)	0.666	4
UniProt:Q7ZYE9 Q7ZYE9			0.639	4
UniProt:Q96PU8 QKI	2	QKI(1-504)-RAF1(278-648) fusion [cytosol] (R-HSA-6802466) QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] (R-HSA-6802546)	0.635	3
UniProt:P26599 PTBP1	1	PTBP1 [nucleoplasm] (R-HSA-71923)	0.553	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q9NZI8 IGF2BP1	1	IGF2BP1 [cytosol] (R-HSA-428366)	0.527	2
UniProt:Q9UBW7 ZMYM2	6	ZMYM2(1-913)-p-FGFR1(429-822) fusion [cytosol] (R-HSA-1839016) ZMYM2(1-913)-FGFR1(429-822) fusion [cytosol] (R-HSA-1604544) ZMYM2(1-1059)-p-4Y-FLT3(594-993) fusion [cytosol] (R-HSA-9703309) ZMYM2(1-1057)-p-5Y-FLT3(586-993) fusion [cytosol] (R-HSA-9703319) ZMYM2(1-1059)-FLT3(594-993) fusion [cytosol] (R-HSA-9703310) ZMYM2(1-1057)-FLT3(586-993) fusion [cytosol] (R-HSA-9703311)	0.524	2
UniProt:Q15365 PCBP1	1	PCBP1 [nucleoplasm] (R-HSA-71919)	0.508	2
UniProt:Q8IUH3 RBM45			0.462	2

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