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HNRNPA1 [nucleoplasm]
Stable Identifier
R-HSA-71927
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP A1, ROA1_HUMAN, Heterogeneous nuclear ribonucleoprotein A1, Helix-destabilizing protein, Single-strand binding protein, hnRNP core protein A1
Locations in the PathwayBrowser for interactor UniProt:P47756 CAPZB
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
FGFR2 alternative splicing (Homo sapiens)
PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)
HNRNPA1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P09651 HNRNPA1
Gene Names
HNRNPA1, HNRPA1
Chain
chain:1-372, initiator methionine:, chain:2-372
Reference Genes
COSMIC (genes):HNRNPA1 HNRNPA1
dbSNP Gene:3178 HNRNPA1
ENSEMBL:ENSG00000135486 HNRNPA1
Participates
as a component of
hnRNP proteins [nucleoplasm] (Homo sapiens)
FGFR2 IIIc-specific splicing complex [nucleoplasm] (Homo sapiens)
as a member of
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
as an input of
PTB and hnRNPA1 bind FGFR2 pre-mRNA to repress IIIb splicing and promote formation of FGFR2c mRNA (Homo sapiens)
Other forms of this molecule
HNRNPA1 [cytosol]
Inferred To
hnrnpa1b [nucleoplasm]
(Danio rerio)
hrp-1 [nucleoplasm]
(Caenorhabditis elegans)
hnrnpa1 [nucleoplasm]
(Xenopus tropicalis)
Hnrnpa1 [nucleoplasm]
(Mus musculus)
Hnrnpa1 [nucleoplasm]
(Rattus norvegicus)
Homologues of HNRNPA1 [nucleoplasm]
(Caenorhabditis elegans)
HNRNPA1 [nucleoplasm]
(Bos taurus)
HNRNPA1 [nucleoplasm]
(Caenorhabditis elegans)
HNRNPA1 [nucleoplasm]
(Canis familiaris)
HNRNPA1 [nucleoplasm]
(Gallus gallus)
HNRNPA1 [nucleoplasm]
(Sus scrofa)
sqd-1 [nucleoplasm]
(Caenorhabditis elegans)
Interactors (68)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.875
10
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.792
5
UniProt:P31943 HNRNPH1
1
HNRNPH1 [nucleoplasm]
(R-HSA-71941)
0.706
4
UniProt:P38159 RBMX
2
RBMX [cytosol]
(R-HSA-9715135)
RBMX [nucleoplasm]
(R-HSA-71939)
0.706
4
UniProt:Q8IUH3 RBM45
0.672
6
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.671
5
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
0.669
3
UniProt:P31942 HNRH3
0.659
3
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.643
4
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.643
3
UniProt:Q96PK6 RBM14
1
RBM14 [nucleoplasm]
(R-HSA-8938345)
0.615
3
UniProt:Q9NZB2 F120A
0.615
3
UniProt:P23246 SFPQ
3
SFPQ [nucleoplasm]
(R-HSA-3900138)
p-Y-SFPQ [nucleoplasm]
(R-HSA-8849461)
SFPQ [cytosol]
(R-HSA-9635505)
0.615
3
UniProt:P14866 HNRNPL
1
HNRNPL [nucleoplasm]
(R-HSA-71947)
0.615
3
UniProt:P59595 N
9
N [cytosol]
(R-COV-9683625)
p-S177-N [cytosol]
(R-COV-9683754)
ADPr-p-S177-N [cytosol]
(R-COV-9686058)
SUMO1-K62-ADPr-p-S177-N [cytosol]
(R-COV-9682916)
SUMO1-K62-ADPr-p-S177-N [viral capsid]
(R-COV-9685478)
SUMO1-K62-ADPr-p-S177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9683641)
N [plasma membrane]
(R-COV-9683611)
SUMO1-K62-ADPr-p-S177-N [nucleolus]
(R-COV-9683730)
SUMO1-K62-ADPr-p-S177-N [plasma membrane]
(R-COV-9686063)
0.602
3
UniProt:P27958-PRO_0000037577
0.599
4
UniProt:Q5BKZ1 ZN326
0.597
4
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.597
4
UniProt:P51991 HNRNPA3
1
HNRNPA3 [nucleoplasm]
(R-HSA-71931)
0.564
2
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.564
2
UniProt:Q8NC51 SERB1
0.548
4
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.536
2
UniProt:P63104 YWHAZ
2
YWHAZ [cytosol]
(R-HSA-206099)
YWHAZ [nucleoplasm]
(R-HSA-450469)
0.536
2
UniProt:Q12906 ILF3
3
ILF3 [nucleoplasm]
(R-HSA-9760401)
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
0.527
2
UniProt:O75319 DUS11
0.527
2
UniProt:P43243 MATR3
0.527
2
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.527
2
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.527
3
UniProt:Q9Y5S9 RBM8A
2
RBM8A [cytosol]
(R-HSA-162462)
RBM8A [nucleoplasm]
(R-HSA-156659)
0.527
2
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.524
2
UniProt:Q8IZH2 XRN1
1
XRN1 [cytosol]
(R-HSA-429835)
0.519
2
UniProt:Q14141 SEPT6
0.499
3
UniProt:Q32P51 RA1L2
0.499
2
UniProt:Q14151 SAFB2
0.483
2
UniProt:Q15717 ELAVL1
6
ELAVL1 [nucleoplasm]
(R-HSA-450601)
p-S158,S221-ELAVL1 [nucleoplasm]
(R-HSA-450576)
p-S221,S318-ELAVL1 [nucleoplasm]
(R-HSA-450532)
ELAVL1 [cytosol]
(R-HSA-450582)
p-S221,S318-ELAVL1 [cytosol]
(R-HSA-450448)
p-S158,S221-ELAVL1 [cytosol]
(R-HSA-450376)
0.483
2
UniProt:Q15233 NONO
0.483
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.483
2
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.483
2
UniProt:Q13151 HNRNPA0
1
HNRNPA0 [nucleoplasm]
(R-HSA-71925)
0.483
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
10
UniProt:Q96I24 FUBP3
0.483
2
UniProt:Q7L2J0 MEPCE
0.483
2
UniProt:Q6UN15 FIP1L1
9
FIP1L1 [nucleoplasm]
(R-HSA-6805150)
FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9672499)
FIP1L1(1-272)-PDGFRA(567-1089) fusion [cytosol]
(R-HSA-9672496)
FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
(R-HSA-9672502)
FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
(R-HSA-9672506)
p-11Y-FIP1L1(1-339)-PDGFRA(580-1089) fusion [cytosol]
(R-HSA-9673872)
p-11Y-FIP1L1(1-392)insDCY-PDGFRA(585-1089) fusion [cytosol]
(R-HSA-9673621)
p-11Y-FIP1L1(1-391)insAQCP-PDGFRA(577-1089) fusion [cytosol]
(R-HSA-9673879)
p-11Y-FIP1L1(1-272)-PDGFRA(567-1069) fusion [cytosol]
(R-HSA-9673867)
0.483
2
UniProt:O43823 AKAP8
0.483
2
UniProt:P47756 CAPZB
1
CAPZB [cytosol]
(R-HSA-879409)
0.483
2
UniProt:Q8IX01 SUGP2
0.483
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
UniProt:Q86VM9 ZCH18
0.483
2
UniProt:Q14966 ZNF638
1
ZNF638 [nucleoplasm]
(R-HSA-8939429)
0.483
2
UniProt:Q12905 ILF2
5
ILF2 [cytosol]
(R-HSA-9836392)
ILF2 [specific granule lumen]
(R-HSA-6799611)
ILF2 [extracellular region]
(R-HSA-6799684)
ILF2 [tertiary granule lumen]
(R-HSA-6800995)
ILF2 [ficolin-1-rich granule lumen]
(R-HSA-6801001)
0.483
2
UniProt:P55265 ADAR
2
ADAR1 [cytosol]
(R-HSA-9835955)
ADAR [nucleoplasm]
(R-HSA-53939)
0.483
2
UniProt:P62316 SNRPD2
2
SNRPD2 [cytosol]
(R-HSA-191810)
SNRPD2 [nucleoplasm]
(R-HSA-71901)
0.483
2
UniProt:O95758 PTBP3
0.483
2
UniProt:Q96KR1 ZFR
0.483
2
UniProt:P78332 RBM6
0.483
2
UniProt:P55795 HNRNPH2
1
HNRNPH2 [nucleoplasm]
(R-HSA-71943)
0.483
2
UniProt:Q13285 NR5A1
3
NR5A1 [nucleoplasm]
(R-HSA-452955)
polySUMO2-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546383)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546382)
0.483
2
UniProt:Q9UKV3 ACIN1
4
ACIN1 [cytosol]
(R-HSA-212519)
ACIN1(1094-1341) [cytosol]
(R-HSA-212516)
ACIN1(1-1093) [cytosol]
(R-HSA-212520)
ACIN1 [nucleoplasm]
(R-HSA-9770238)
0.483
2
UniProt:Q9HCK8 CHD8
1
CHD8 [nucleoplasm]
(R-HSA-3221598)
0.483
2
UniProt:Q9BXP5 SRRT
1
SRRT [nucleoplasm]
(R-HSA-6814858)
0.483
2
UniProt:Q9UKV8 AGO2
2
AGO2 [cytosol]
(R-HSA-209723)
AGO2 [nucleoplasm]
(R-HSA-5578701)
0.483
2
UniProt:Q9H0D6 XRN2
2
XRN2 [nucleoplasm]
(R-HSA-6791205)
XRN2 [cytosol]
(R-HSA-391297)
0.483
2
UniProt:Q15424 SAFB
3
monoSUMO1-K231,K294-SAFB [nucleoplasm]
(R-HSA-4085343)
polySUMO2,3-K231,K294-SAFB [nucleoplasm]
(R-HSA-4085357)
SAFB [nucleoplasm]
(R-HSA-4085379)
0.483
2
UniProt:Q16630 CPSF6
2
CPSF6(1-490)-FGFR1(429-822) fusion [cytosol]
(R-HSA-1614368)
CPSF6(1-490)-p-FGFR1(429-822) fusion [cytosol]
(R-HSA-1838987)
0.483
2
UniProt:Q14498 RBM39
1
RBM39 [nucleoplasm]
(R-HSA-9770254)
0.483
2
IntAct:EBI-6857440 NS3
0.462
2
UniProt:O60477 BRNP1
0.462
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.462
2
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