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HNRNPA2B1 [nucleoplasm]
Stable Identifier
R-HSA-71929
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP A2, ROA2_HUMAN, Heterogeneous nuclear ribonucleoproteins A2/B1, hnRNP A2 / hnRNP B1
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of pre-mRNPs (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPA2B1 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P22626 HNRNPA2B1
Gene Names
HNRNPA2B1, HNRPA2B1
Chain
chain:1-353
Reference Genes
BioGPS Gene:3181 HNRNPA2B1
COSMIC (genes):HNRNPA2B1 HNRNPA2B1
CTD Gene:3181 HNRNPA2B1
dbSNP Gene:3181 HNRNPA2B1
ENSEMBL:ENSG00000122566 HNRNPA2B1
ENSEMBL_homo_sapiens_GENE:ENSG00000122566.22 HNRNPA2B1
HGNC:5033 HNRNPA2B1
KEGG Gene (Homo sapiens):3181 HNRNPA2B1
Monarch:3181 HNRNPA2B1
NCBI Gene:3181 HNRNPA2B1
OMIM:600124 HNRNPA2B1
UCSC:P22626 HNRNPA2B1
Reference Transcript
RefSeq:XM_017012110.1 HNRNPA2B1
RefSeq:NM_002137.3 HNRNPA2B1
RefSeq:NM_031243.2 HNRNPA2B1
RefSeq:XM_005249729.1 HNRNPA2B1
RefSeq:XM_017012109.1 HNRNPA2B1
Other Identifiers
11742679_s_at
11742680_at
17056031
205292_3p_s_at
205292_PM_s_at
205292_s_at
225107_PM_at
225107_at
225932_PM_s_at
225932_s_at
240089_PM_at
240089_at
3042402
3042404
3042405
3042407
3042416
3042420
3042422
3042423
3042424
3042425
3042426
3042427
3042428
3042429
3042430
3042431
3042432
3042433
3042434
3042435
3042436
3042437
3042438
3042439
3042440
3042441
3042443
3042449
3042450
3042452
3042453
3042455
3042456
3042457
3042458
3042460
3042465
3042466
3042467
3042468
3042469
3042470
3042471
3042472
3042473
3042474
3042475
3042476
3181
36654_s_at
75485_at
78748_at
78749_g_at
8138670
88815_s_at
91752_at
A_24_P3973
A_33_P3337318
A_33_P3362891
GE81123
GE86684
GO:0000122
GO:0000398
GO:0000781
GO:0003676
GO:0003677
GO:0003723
GO:0003730
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005681
GO:0005694
GO:0005737
GO:0006351
GO:0006355
GO:0006397
GO:0006406
GO:0006913
GO:0008380
GO:0015030
GO:0016020
GO:0016071
GO:0016363
GO:0031047
GO:0031053
GO:0032200
GO:0035198
GO:0042802
GO:0043047
GO:0043226
GO:0043231
GO:0044806
GO:0048025
GO:0050658
GO:0051028
GO:0060090
GO:0070062
GO:0071013
GO:0097157
GO:0098505
GO:0140693
GO:1904358
GO:1905663
GO:1990247
GO:1990428
GO:1990904
HMNXSV003026027
HMNXSV003036875
Hs.232400.0.S1_3p_a_at
Hs.232400.1.S1_3p_s_at
Hs.301185.0.A1_3p_at
ILMN_1886493
ILMN_2369682
M29064_at
PH_hs_0012740
PH_hs_0037449
TC07001214.hg
TC07002845.hg
g4504446_3p_a_at
g4504446_3p_s_at
Participates
as a component of
hnRNP proteins [nucleoplasm] (Homo sapiens)
as a member of
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
Other forms of this molecule
HNRNPA2B1 [extracellular exosome]
Inferred To
hrp-1 [nucleoplasm]
(Caenorhabditis elegans)
HNRNPA2B1 [nucleoplasm]
(Bos taurus)
HNRNPA2B1 [nucleoplasm]
(Caenorhabditis elegans)
HNRNPA2B1 [nucleoplasm]
(Canis familiaris)
HNRNPA2B1 [nucleoplasm]
(Gallus gallus)
HNRNPA2B1 [nucleoplasm]
(Sus scrofa)
Hnrnpa2b1 [nucleoplasm]
(Mus musculus)
Hnrnpa2b1 [nucleoplasm]
(Rattus norvegicus)
Homologues of HNRNPA2B1 [nucleoplasm]
(Caenorhabditis elegans)
sqd-1 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_005249786.1
,
NP_002128.1
,
XP_016867598.1
,
NP_112533.1
,
XP_016867599.1
OpenTargets
ENSG00000122566
HPA
ENSG00000122566-HNRNPA2B1
GeneCards
P22626
Ensembl
ENST00000677631
,
ENST00000679243
,
ENSP00000503429
,
ENSP00000503452
,
ENSP00000503501
,
ENST00000677396
,
ENSP00000504023
,
ENSG00000122566
,
ENSP00000503836
,
ENST00000679318
,
ENST00000678675
,
ENSP00000503460
,
ENSP00000503514
,
ENSP00000354021
,
ENSP00000504329
,
ENST00000676497
,
ENST00000677656
,
ENSP00000504721
,
ENSP00000497298
,
ENST00000354667
,
ENST00000678779
,
ENSP00000503047
,
ENSP00000503961
,
ENST00000677839
,
ENST00000676746
,
ENST00000356674
,
ENSP00000346694
,
ENST00000678697
,
ENSP00000503703
,
ENST00000678962
,
ENSP00000503360
,
ENST00000678449
,
ENSP00000478691
,
ENST00000679001
,
ENST00000677906
,
ENSP00000504799
,
ENST00000678884
,
ENSP00000504439
,
ENSP00000503375
,
ENSP00000504660
,
ENST00000678998
,
ENSP00000504831
,
ENST00000618183
,
ENST00000360787
,
ENSP00000503833
,
ENST00000676524
,
ENST00000608362
,
ENSP00000349101
,
ENST00000678431
,
ENSP00000503021
,
ENST00000677339
,
ENST00000679123
,
ENST00000679021
,
ENSP00000503476
,
ENST00000678501
,
ENSP00000503060
,
ENST00000677574
,
ENSP00000504415
,
ENST00000678935
,
ENSP00000503870
,
ENST00000676749
,
ENSP00000503885
,
ENSP00000503242
,
ENSP00000504571
,
ENST00000676903
PRO
P22626
Pharos - Targets
P22626
Orphanet
22022
PDB
6WQK
,
8DUW
,
5WWF
,
6WPQ
,
8DU2
,
8EC7
,
5HO4
,
5WWE
,
7WM3
,
8HNI
,
5EN1
,
1X4B
,
5WWG
Interactors (32)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14103 HNRNPD
1
HNRNPD [nucleoplasm]
(R-HSA-71935)
0.669
4
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.669
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.643
5
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.643
3
UniProt:P14866-1 HNRNPL
0.632
4
UniProt:P14866 HNRNPL
1
HNRNPL [nucleoplasm]
(R-HSA-71947)
0.623
4
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.623
4
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.615
14
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.597
4
UniProt:Q13151 HNRNPA0
1
HNRNPA0 [nucleoplasm]
(R-HSA-71925)
0.564
2
UniProt:Q5T7N2 LITD1
0.564
2
UniProt:P51991 HNRNPA3
1
HNRNPA3 [nucleoplasm]
(R-HSA-71931)
0.564
2
UniProt:Q99729 ROAA
0.564
2
UniProt:P61978 HNRNPK
2
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
HNRNPK [nucleoplasm]
(R-HSA-71945)
0.564
2
UniProt:P52272 HNRNPM
1
HNRNPM [nucleoplasm]
(R-HSA-71949)
0.564
2
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.564
3
UniProt:O14979 HNRNPDL
1
HNRNPDL [cytosol]
(R-HSA-8950323)
0.564
2
UniProt:Q12906 ILF3
3
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [cytosol]
(R-HSA-450564)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.564
3
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.564
3
IntAct:EBI-11709120 LNC
0.558
6
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.527
2
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.527
2
UniProt:Q96CW1 AP2M1
6
AP2M1 [plasma membrane]
(R-HSA-167585)
AP2M1 [lysosomal membrane]
(R-HSA-196144)
AP2M1 [cytosol]
(R-HSA-182227)
AP2M1 [clathrin-coated endocytic vesicle membrane]
(R-HSA-2130423)
AP2M1 [endolysosome membrane]
(R-HSA-6784828)
p-T156 AP2M1 [cytosol]
(R-HSA-8856805)
0.527
2
UniProt:P62993 GRB2
1
GRB2 [cytosol]
(R-HSA-8983328)
0.527
2
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
2
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.527
2
UniProt:Q9HA38 ZMAT3
0.524
3
UniProt:Q13936 CACNA1C
1
CACNA1C [plasma membrane]
(R-HSA-265551)
0.499
2
UniProt:O60741 HCN1
1
HCN1 [plasma membrane]
(R-HSA-977503)
0.499
3
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.483
2
UniProt:Q4G0J3 LARP7
0.483
2
UniProt:Q8IUH3 RBM45
0.462
3
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