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HNRNPC [nucleoplasm]
Stable Identifier
R-HSA-71933
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP C1/C2, ROC_HUMAN, Heterogeneous nuclear ribonucleoproteins C1/C2, hnRNP C1 / hnRNP C2
Locations in the PathwayBrowser for interactor UniProt:Q9UKM9 RALY
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of RNA binding proteins (Homo sapiens)
RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)
HNRNPC [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P07910 HNRNPC
Gene Names
HNRNPC, HNRPC
Chain
initiator methionine:, chain:2-306
Reference Genes
BioGPS Gene:3183 HNRNPC
COSMIC (genes):HNRNPC HNRNPC
CTD Gene:3183 HNRNPC
dbSNP Gene:3183 HNRNPC
ENSEMBL:ENSG00000092199 HNRNPC
ENSEMBL_homo_sapiens_GENE:ENSG00000092199.19 HNRNPC
HGNC:5035 HNRNPC
KEGG Gene (Homo sapiens):3183 HNRNPC
Monarch:3183 HNRNPC
NCBI Gene:3183 HNRNPC
OMIM:164020 HNRNPC
UCSC:P07910 HNRNPC
Reference Transcript
RefSeq:XM_017021253.1 HNRNPC
RefSeq:NM_004500.3 HNRNPC
RefSeq:XM_006720125.2 HNRNPC
RefSeq:XM_011536712.1 HNRNPC
RefSeq:NM_001077442.1 HNRNPC
RefSeq:XM_011536710.2 HNRNPC
RefSeq:XM_017021252.1 HNRNPC
RefSeq:NM_001077443.1 HNRNPC
RefSeq:XM_011536708.1 HNRNPC
RefSeq:XM_011536711.2 HNRNPC
RefSeq:NM_031314.2 HNRNPC
RefSeq:XM_011536709.2 HNRNPC
Other Identifiers
11732246_a_at
11732247_s_at
11756337_x_at
11758144_x_at
1568941_3p_a_at
1568941_PM_a_at
1568941_a_at
16653739
16653741
16653743
16653745
16653747
18671138
18671144
18671145
18671146
18671147
18671148
18671149
200014_PM_s_at
200014_s_at
200751_PM_s_at
200751_s_at
212626_PM_x_at
212626_x_at
214737_3p_x_at
214737_PM_x_at
214737_x_at
227110_PM_at
227110_at
2520052
2520055
2520056
2520057
3183
32408_s_at
3343617
33666_at
3384883
3555883
3555884
3555885
3555886
3555887
3555888
3555889
3555891
3555893
3555896
3555897
3555898
3555903
3555905
3555906
3555907
3555908
3555909
3555922
3555923
3555924
3555925
3555926
3555927
3555928
3555932
3556310
3556312
3556314
3556316
3556318
3556320
3556322
3648218
723_s_at
7892621
7892865
7892979
7893081
7893196
7893325
7893460
7894042
7894045
7894107
7894110
7894294
7894404
7894439
7894595
7894914
7894953
7895062
7895404
7895571
7895574
7896007
7896256
7896423
7977657
8047059
A_23_P163006
A_32_P142028
A_33_P3294017
GE61328
GO:0000398
GO:0000785
GO:0001649
GO:0003676
GO:0003677
GO:0003723
GO:0003730
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005681
GO:0005694
GO:0005697
GO:0005829
GO:0005856
GO:0006325
GO:0006338
GO:0006397
GO:0008266
GO:0008380
GO:0015629
GO:0016020
GO:0016071
GO:0030154
GO:0031492
GO:0032200
GO:0032211
GO:0032991
GO:0042802
GO:0043226
GO:0070034
GO:0070062
GO:0070935
GO:0071013
GO:1990247
GO:1990904
HMNXSV003005460
Hs.182447.0.A1_3p_a_at
Hs.182447.0.A1_3p_x_at
Hs.182447.1.A1_3p_x_at
Hs.182447.2.A1_3p_at
Hs.182447.3.A1_3p_a_at
Hs2.250158.1.S1_3p_at
Hs2.250158.1.S1_3p_s_at
ILMN_2334587
M16342_at
PH_hs_0030525
TC14000915.hg
g4758543_3p_a_at
Participates
as an input of
RANBP2 (NUP358) SUMOylates HNRNPC with SUMO1 (Homo sapiens)
as a component of
hnRNP proteins [nucleoplasm] (Homo sapiens)
as a member of
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
Other forms of this molecule
HNRNPC [cytosol]
SUMO1-K250-HNRNPC [nucleoplasm]
Inferred To
hnrnpc [nucleoplasm]
(Xenopus tropicalis)
Hnrnpc [nucleoplasm]
(Mus musculus)
Hnrnpc [nucleoplasm]
(Rattus norvegicus)
CG18656 [nucleoplasm]
(Drosophila melanogaster)
HNRNPC [nucleoplasm]
(Schizosaccharomyces pombe)
HNRNPC [nucleoplasm]
(Sus scrofa)
NAB3 [nucleoplasm]
(Saccharomyces cerevisiae)
HNRPC [nucleoplasm]
(Bos taurus)
LOC119869089 [nucleoplasm]
(Canis familiaris)
Cross References
RefSeq
XP_016876742.1
,
XP_011535011.1
,
NP_001070910.1
,
NP_004491.2
,
XP_006720188.1
,
XP_011535014.1
,
NP_112604.2
,
NP_001070911.1
,
XP_016876741.1
,
XP_011535013.1
,
XP_011535012.1
,
XP_011535010.1
OpenTargets
ENSG00000092199
HPA
ENSG00000092199-HNRNPC
GeneCards
P07910
Ensembl
ENST00000556628
,
ENSP00000451652
,
ENSP00000450629
,
ENSP00000450725
,
ENSP00000452276
,
ENSP00000451176
,
ENST00000554455
,
ENST00000557201
,
ENST00000554969
,
ENST00000555883
,
ENSP00000450544
,
ENST00000430246
,
ENSP00000451291
,
ENST00000556897
,
ENSP00000442816
,
ENSG00000092199
,
ENSP00000404848
,
ENST00000420743
,
ENST00000553300
PRO
P07910
Pharos - Targets
P07910
PDB
2MXY
,
1WF2
,
3LN4
,
1TXP
,
2MZ1
Interactors (102)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P07910 HNRNPC
3
HNRNPC [cytosol]
(R-HSA-9715136)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [nucleoplasm]
(R-HSA-71933)
0.863
8
UniProt:O00505 KPNA3
2
KPNA3 [nucleoplasm]
(R-HSA-1176061)
KPNA3 [cytosol]
(R-HSA-1176070)
0.845
7
UniProt:O00629 KPNA4
2
KPNA4 [cytosol]
(R-HSA-1176066)
KPNA4 [nucleoplasm]
(R-HSA-1176058)
0.834
8
UniProt:P09651 HNRNPA1
2
HNRNPA1 [cytosol]
(R-HSA-9727902)
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
0.792
5
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.749
5
UniProt:Q86SE5 RALYL
0.742
7
UniProt:Q9UKM9 RALY
0.742
5
UniProt:Q96IZ5 RBM41
0.742
5
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.731
4
UniProt:O00560 SDCBP
3
SDCBP [extracellular region]
(R-HSA-6806206)
SDCBP [azurophil granule lumen]
(R-HSA-6799372)
SDCBP [cytosol]
(R-HSA-373639)
0.718
6
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.718
6
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
18
UniProt:Q12906 ILF3
3
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [cytosol]
(R-HSA-450564)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.706
4
UniProt:P42858 HTT
1
HTT [nucleoplasm]
(R-HSA-9023590)
0.675
7
UniProt:P52292 KPNA2
2
KPNA2 [nucleoplasm]
(R-HSA-206045)
KPNA2 [cytosol]
(R-HSA-205976)
0.666
4
UniProt:B2RXH8 HNRC2
0.666
4
UniProt:O60812 HNRC1
0.666
6
UniProt:P63104 YWHAZ
2
YWHAZ [nucleoplasm]
(R-HSA-450469)
YWHAZ [cytosol]
(R-HSA-206099)
0.65
3
UniProt:Q09161 NCBP1
2
NCBP1 [nucleoplasm]
(R-HSA-51469)
NCBP1 [cytosol]
(R-HSA-162459)
0.643
5
UniProt:Q13435 SF3B2
1
SF3B2 [nucleoplasm]
(R-HSA-71971)
0.64
3
UniProt:O60506 HNRPQ
0.615
3
UniProt:Q53F19 NCBP3
0.615
4
UniProt:Q96KR1 ZFR
0.615
3
UniProt:Q96SI9 STRBP
0.615
3
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.615
3
UniProt:O43390 HNRNPR
1
HNRNPR [nucleoplasm]
(R-HSA-71951)
0.615
3
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.615
6
UniProt:Q8IUH3 RBM45
0.597
3
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.597
4
UniProt:Q96QD9 FYTTD1
1
FYTTD1 [nucleoplasm]
(R-HSA-8852176)
0.564
2
UniProt:P01106 MYC
2
PolyUb-MYC [nucleoplasm]
(R-HSA-6783169)
MYC [nucleoplasm]
(R-HSA-188379)
0.564
2
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
0.564
3
UniProt:Q9NQR1 KMT5A
1
SETD8 [nucleoplasm]
(R-HSA-417142)
0.564
2
UniProt:Q6ZRY4 RBPS2
0.556
3
UniProt:P78317 RNF4
2
RNF4 [nucleoplasm]
(R-HSA-5684076)
RNF4 [cytosol]
(R-HSA-975974)
0.556
3
UniProt:Q86SE5-3 RALYL
0.556
3
UniProt:Q13148 TADBP
0.556
3
UniProt:O15131 KPNA5
2
KPNA5 [nucleoplasm]
(R-HSA-1176068)
KPNA5 [cytosol]
(R-HSA-1176062)
0.556
3
UniProt:Q7KZS0 Q7KZS0
0.556
3
UniProt:Q6FHY5 Q6FHY5
0.556
3
UniProt:Q53GL6 Q53GL6
0.556
3
UniProt:Q12929 EPS8
1
EPS8 [cytosol]
(R-HSA-9662382)
0.556
3
UniProt:P26367 PAX6
1
PAX6 [nucleoplasm]
(R-HSA-3009044)
0.556
3
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.556
3
UniProt:Q68DK2-5 ZFYVE26
0.556
3
UniProt:Q9NRI5-2 DISC1
0.556
3
IntAct:EBI-10178797 4005
0.556
3
UniProt:P38340 NTM1
0.556
3
UniProt:G2XKQ0 SUMO5
0.556
3
UniProt:Q14103 HNRNPD
1
HNRNPD [nucleoplasm]
(R-HSA-71935)
0.547
3
UniProt:Q9Y618 NCOR2
2
monoSUMO1-K672-NCOR2 [nucleoplasm]
(R-HSA-3927904)
NCOR2 [nucleoplasm]
(R-HSA-442469)
0.536
2
UniProt:Q9UHX1 PUF60
1
PUF60 [nucleoplasm]
(R-HSA-8865910)
0.536
2
UniProt:Q92917 GPKOW
1
GPKOW [nucleoplasm]
(R-HSA-8850839)
0.536
3
UniProt:Q9NQZ2 UTP3
1
UTP3 [nucleoplasm]
(R-HSA-6790637)
0.536
3
UniProt:Q9H9Z2 LIN28A
1
LIN28A [cytosol]
(R-HSA-500391)
0.527
3
UniProt:P14866 HNRNPL
1
HNRNPL [nucleoplasm]
(R-HSA-71947)
0.527
3
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
4
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.527
2
UniProt:P09234 SNRPC
1
SNRPC [nucleoplasm]
(R-HSA-8865876)
0.527
2
UniProt:P38919 EIF4A3
2
EIF4A3 [nucleoplasm]
(R-HSA-8849149)
EIF4A3 [cytosol]
(R-HSA-927868)
0.527
2
UniProt:P49761 CLK3
0.527
2
UniProt:Q9NZB2 F120A
0.527
2
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
2
UniProt:P78362 SRPK2
1
SRPK2 [cytosol]
(R-HSA-9729332)
0.525
2
UniProt:Q92879 CELF1
0.519
2
UniProt:Q9BYB0 SHANK3
1
SHANK3 [cytosol]
(R-HSA-6794277)
0.508
2
UniProt:Q9NYF8 BCLF1
0.483
2
UniProt:Q8WXF1 PSPC1
0.483
2
UniProt:O14979 HNRNPDL
1
HNRNPDL [cytosol]
(R-HSA-8950323)
0.483
2
UniProt:P52294 KPNA1
2
KPNA1 [cytosol]
(R-HSA-180612)
KPNA1 [nucleoplasm]
(R-HSA-188865)
0.483
2
UniProt:P17844 DDX5
4
DDX5 [nucleoplasm]
(R-HSA-3900136)
DDX5 [cytosol]
(R-HSA-9682643)
polySUMO2-K53-DDX5 [nucleoplasm]
(R-HSA-3900186)
monoSUMO1-K53-DDX5 [nucleoplasm]
(R-HSA-3900041)
0.483
2
UniProt:Q13151 HNRNPA0
1
HNRNPA0 [nucleoplasm]
(R-HSA-71925)
0.483
2
UniProt:Q07666 KHDRBS1
3
p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm]
(R-HSA-8848970)
p-Y435,Y440,Y443-KHDRBS1 [cytosol]
(R-HSA-8848995)
KHDRBS1 [nucleoplasm]
(R-HSA-8848941)
0.483
2
UniProt:Q1KMD3 HNRL2
0.483
2
UniProt:Q8IX01 SUGP2
0.483
2
UniProt:O75152 ZC3H11A
1
ZC3H11A [nucleoplasm]
(R-HSA-8850659)
0.483
2
UniProt:Q9HCK8 CHD8
1
CHD8 [nucleoplasm]
(R-HSA-3221598)
0.483
2
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
UniProt:Q8NEY8 PPHLN1
1
PPHLN1 [nucleoplasm]
(R-HSA-9844032)
0.483
2
UniProt:Q86VM9 ZCH18
0.483
6
UniProt:Q9BQ04 RBM4B
0.483
2
UniProt:Q9BZJ0 CRNKL1
1
CRNKL1 [nucleoplasm]
(R-HSA-8867899)
0.483
2
UniProt:Q13595 TRA2A
0.483
2
UniProt:Q14562 DHX8
1
DHX8 [nucleoplasm]
(R-HSA-5688092)
0.483
2
UniProt:Q14974 KPNB1
5
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [cytosol]
(R-HSA-180733)
0.483
2
UniProt:Q2TBE0 CWF19L2
1
CWF19L2 [nucleoplasm]
(R-HSA-9770846)
0.483
2
UniProt:Q14151 SAFB2
0.483
2
UniProt:Q9NW64 RBM22
1
RBM22 [nucleoplasm]
(R-HSA-5215975)
0.483
2
UniProt:O75533 SF3B1
1
SF3B1 [nucleoplasm]
(R-HSA-71968)
0.483
2
UniProt:Q9Y6M1 IGF2BP2
1
IGF2BP2 [cytosol]
(R-HSA-428302)
0.483
2
UniProt:O15226 NKRF
0.483
2
UniProt:O15504 NUP42
1
NUPL2 [cytosol]
(R-HSA-157697)
0.483
2
UniProt:Q9NUL3 STAU2
0.483
2
UniProt:Q9Y2W1 THRAP3
1
THRAP3 [nucleoplasm]
(R-HSA-8932115)
0.483
2
UniProt:Q15003 NCAPH
3
p-T-NCAPH [cytosol]
(R-HSA-2517885)
p-S570-NCAPH [cytosol]
(R-HSA-2529017)
NCAPH [cytosol]
(R-HSA-1638139)
0.483
2
UniProt:P09012 SNRPA
1
SNRPA [nucleoplasm]
(R-HSA-71915)
0.483
2
UniProt:Q13285 NR5A1
3
NR5A1 [nucleoplasm]
(R-HSA-452955)
polySUMO2-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546383)
monoSUMO1-K119,K194-NR5A1 [nucleoplasm]
(R-HSA-4546382)
0.483
2
UniProt:Q96DF8 ESS2
0.483
2
UniProt:Q6PJT7 ZC3HE
0.483
2
UniProt:Q15459 SF3A1
1
SF3A1 [nucleoplasm]
(R-HSA-71962)
0.483
2
UniProt:Q9H307 PNN
1
PNN [nucleoplasm]
(R-HSA-9770779)
0.483
2
UniProt:O95758 PTBP3
0.483
2
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