Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HNRNPL [nucleoplasm]
Stable Identifier
R-HSA-71947
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP L, ROL_HUMAN, Heterogeneous nuclear ribonucleoprotein L
Locations in the PathwayBrowser
Expand all
Disease (Homo sapiens)
Infectious disease (Homo sapiens)
Viral Infection Pathways (Homo sapiens)
Dengue Virus Infection (Homo sapiens)
Dengue Virus-Host Interactions (Homo sapiens)
NS5 interacts with Spliceosome (Homo sapiens)
NS5:Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of pre-mRNPs (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
mRNA 3'-end processing (Homo sapiens)
mRNA Polyadenylation (Homo sapiens)
CPA complex components dissociate from polyadenylated pre-mRNA (distal 3'UTR PAS) (Homo sapiens)
Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
CPA complex components dissociate from polyadenylated pre-mRNA (intronic PAS) (Homo sapiens)
Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
CPA complex components dissociate from polyadenylated pre-mRNA (proximal 3'UTR PAS) (Homo sapiens)
Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
CPSF3 cleaves pre-mRNA at distal 3'UTR PAS (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
CPSF3 cleaves pre-mRNA at proximal 3'UTR PAS (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Core CPA complex binds capped pre-mRNA (Homo sapiens)
Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
PABPN1-stimulated PAPOL synthesizes polyA tail at distal 3'UTR PAS (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at distal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
PABPN1-stimulated PAPOL synthesizes polyA tail at intronic PAS (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at intronic PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
PABPN1-stimulated PAPOL synthesizes polyA tail at proximal 3'UTR PAS (Homo sapiens)
Ub-K63-CPA:PABPN1:Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA polyadenylated at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at proximal 3'UTR PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
PP1 dephosphorylates RNA Pol II (Homo sapiens)
CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
RBBP6 activates CPSF complex (Homo sapiens)
CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Recruitment of other CPA components to pre-mRNA-bound CPA core (Homo sapiens)
CPA:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Core CPA complex:Spliceosomal A complex (uncleaved pre-mRNA) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
U1 snRNP suppresses CPSF3-mediated pre-mRNA cleavage at intronic PAS (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (pre-mRNA cleaved at intronal PAS) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (pre-mRNA cleaved at intronic PAS) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Ub-K63-CPA:Spliceosomal A complex (uncleaved pre-mRNA, RNA Pol II Ser2 dephosphorylated) [nucleoplasm] (Homo sapiens)
Spliceosomal A complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex (RNA Pol II Ser5 dephosphorylated) [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex (capped, methylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C complex containing intron lariat (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex (capped, methylated, polyadenylated pre-mRNA) [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated, polyadenylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPL [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P14866 HNRNPL
Gene Names
HNRNPL, HNRPL, P/OKcl.14
Chain
chain:1-589
Reference Genes
BioGPS Gene:3191 HNRNPL
COSMIC (genes):HNRNPL HNRNPL
CTD Gene:3191 HNRNPL
dbSNP Gene:3191 HNRNPL
ENSEMBL:ENSG00000104824 HNRNPL
HGNC:5045 HNRNPL
KEGG:hsa:3191 HNRNPL
Monarch:3191 HNRNPL
NCBI Gene:3191 HNRNPL
OMIM:603083 HNRNPL
UCSC:P14866 HNRNPL
Reference Transcript
RefSeq:XM_011526889.1 HNRNPL
RefSeq:NM_001005335.2 HNRNPL
RefSeq:NM_001533.2 HNRNPL
Participates
as a component of
hnRNP proteins [nucleoplasm] (Homo sapiens)
as a member of
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
Inferred To
hnrnpl [nucleoplasm]
(Danio rerio)
hnrnpl [nucleoplasm]
(Xenopus tropicalis)
sm [nucleoplasm]
(Drosophila melanogaster)
Hnrnpl [nucleoplasm]
(Mus musculus)
Hnrnpl [nucleoplasm]
(Rattus norvegicus)
HNRNPL [nucleoplasm]
(Bos taurus)
HNRNPL [nucleoplasm]
(Canis familiaris)
HNRNPL [nucleoplasm]
(Dictyostelium discoideum)
HNRNPL [nucleoplasm]
(Plasmodium falciparum)
HNRNPL [nucleoplasm]
(Sus scrofa)
hrpl-1 [nucleoplasm]
(Caenorhabditis elegans)
LOC101749377 [nucleoplasm]
(Gallus gallus)
Cross References
RefSeq
XP_011525191.1
,
NP_001005335.1
,
NP_001524.2
OpenTargets
ENSG00000104824
ENSEMBL
ENST00000634237
,
ENST00000221419
,
ENSP00000470231
,
ENSP00000221419
,
ENSP00000489244
,
ENST00000600873
,
ENSG00000104824
,
ENSP00000489021
,
ENST00000634753
,
ENSG00000282947
HPA
ENSG00000104824-HNRNPL
GeneCards
HNRNPL
PRO
P14866
Pharos - Targets
P14866
GlyGen
P14866
PDB
3R27
,
3TO8
,
7EVR
Interactors (11)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P61978 HNRNPK
2
HNRNPK [nucleoplasm]
(R-HSA-71945)
polySUMO2-K422-HNRNPK [nucleoplasm]
(R-HSA-4570532)
0.649
5
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
0.623
4
UniProt:P09651 HNRNPA1
2
HNRNPA1 [nucleoplasm]
(R-HSA-71927)
HNRNPA1 [cytosol]
(R-HSA-9727902)
0.615
3
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
0.615
12
UniProt:P07910 HNRNPC
3
HNRNPC [nucleoplasm]
(R-HSA-71933)
SUMO1-K250-HNRNPC [nucleoplasm]
(R-HSA-4570543)
HNRNPC [cytosol]
(R-HSA-9715136)
0.527
3
UniProt:Q00839 HNRNPU
1
HNRNPU [nucleoplasm]
(R-HSA-71953)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
0.527
4
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.527
2
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [extracellular region]
(R-HSA-9017791)
YBX1 [nucleoplasm]
(R-HSA-72041)
0.527
3
UniProt:Q12906 ILF3
3
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
ILF3 [nucleoplasm]
(R-HSA-9760401)
0.527
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.483
2
© 2025
Reactome
This website requires cookies and the limited processing of your personal data in order to function. By using the site you are agreeing to this as outlined in our
Privacy Notice
.
I agree, dismiss this banner
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
