Reactome | HNRNPL [nucleoplasm]

HNRNPL [nucleoplasm]

Stable Identifier

R-HSA-71947

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

hnRNP L, ROL_HUMAN, Heterogeneous nuclear ribonucleoprotein L

Locations in the PathwayBrowser

Expand all

Metabolism of RNA (Homo sapiens)

- Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
  - Formation of pre-mRNPs (Homo sapiens)
    - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
      - shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
    - capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
      - Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
  - mRNA Splicing (Homo sapiens)
    - mRNA Splicing - Major Pathway (Homo sapiens)
      - Formation of the Spliceosomal A complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal B* complex (Homo sapiens)
        
        Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Bact complex (Homo sapiens)
        
        Spliceosomal B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal C* complex (Homo sapiens)
        
        Spliceosomal C complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal E complex (Homo sapiens)
        
        Spliceosomal E complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
        
        Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
      - Formation of the Spliceosomal Pre-B complex (Homo sapiens)
        
        Spliceosomal A complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
        
        capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
      - Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
        
        Spliceosomal P complex [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)
        
        spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
        
        Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
        
        shuttling HNRNPs [nucleoplasm] (Homo sapiens)
        
        HNRNPL [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P14866 HNRNPL

Gene Names

HNRNPL, HNRPL, P/OKcl.14

Chain

chain:1-589

Reference Genes

BioGPS Gene:3191 HNRNPL

COSMIC (genes):HNRNPL HNRNPL

CTD Gene:3191 HNRNPL

dbSNP Gene:3191 HNRNPL

ENSEMBL:ENSG00000104824 HNRNPL

ENSEMBL:ENSG00000104824.18 HNRNPL

ENSEMBL:ENSG00000282947.2 HNRNPL

HGNC:5045 HNRNPL

KEGG Gene (Homo sapiens):3191 HNRNPL

Monarch:3191 HNRNPL

NCBI Gene:3191 HNRNPL

OMIM:603083 HNRNPL

UCSC:P14866 HNRNPL

Reference Transcript

Other Identifiers

11726224_s_at

11753332_s_at

16872052

202072_PM_at

202072_at

2940655

2940664

2940666

3191

35201_PM_at

35201_at

3617560

3617562

3617563

3617569

3861618

3861619

3861621

3861623

3861624

3861626

3861629

3861631

3861640

3861642

3861645

3861647

3861649

3861652

3861653

3861654

3861655

45504_f_at

8036613

A_23_P119677

GE59731

GO:0000381

GO:0000785

GO:0000976

GO:0003676

GO:0003677

GO:0003723

GO:0003729

GO:0005515

GO:0005576

GO:0005615

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0006351

GO:0006355

GO:0006396

GO:0006397

GO:0016020

GO:0016071

GO:0035770

GO:0043226

GO:0043484

GO:0045892

GO:0070062

GO:0097157

GO:1990904

HMNXSV003037114

HMNXSV003040246

ILMN_2389582

PH_hs_0033554

TC19002699.hg

X16135_at

g4557644_3p_s_at

p33943

Participates

as a component of

hnRNP proteins [nucleoplasm] (Homo sapiens)

as a member of

shuttling HNRNPs [nucleoplasm] (Homo sapiens)

Inferred To

hnrnpl [nucleoplasm] (Danio rerio)

hnrnpl [nucleoplasm] (Xenopus tropicalis)

sm [nucleoplasm] (Drosophila melanogaster)

Hnrnpl [nucleoplasm] (Mus musculus)

Hnrnpl [nucleoplasm] (Rattus norvegicus)

Homologues of HNRNPL [nucleoplasm] (Danio rerio)

HNRNPL [nucleoplasm] (Bos taurus)

HNRNPL [nucleoplasm] (Canis familiaris)

HNRNPL [nucleoplasm] (Danio rerio)

HNRNPL [nucleoplasm] (Dictyostelium discoideum)

HNRNPL [nucleoplasm] (Gallus gallus)

HNRNPL [nucleoplasm] (Plasmodium falciparum)

HNRNPL [nucleoplasm] (Sus scrofa)

hrpl-1 [nucleoplasm] (Caenorhabditis elegans)

Cross References

RefSeq

NP_001005335.1, NP_001524.2, XP_011525191.1

OpenTargets

ENSG00000104824

GeneCards

P14866

HPA

ENSG00000104824-HNRNPL

Ensembl

ENST00000600873, ENST00000221419, ENSP00000470231, ENSP00000221419, ENST00000634753, ENSP00000489021, ENST00000634237, ENSG00000282947, ENSP00000489244, ENSG00000104824

PRO

P14866

Pharos - Targets

P14866

PDB

7EVR, 3R27, 3TO8

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	12
UniProt:P61978 HNRNPK	2	polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532) HNRNPK [nucleoplasm] (R-HSA-71945)	0.537	4
UniProt:P67809 YBX1	5	p-S32,S36-YBX1 [nucleoplasm] (R-HSA-9733227) p-S32,S36-YBX1 [cytosol] (R-HSA-9736837) YBX1 [cytosol] (R-HSA-9736840) YBX1 [nucleoplasm] (R-HSA-72041) YBX1 [extracellular region] (R-HSA-9017791)	0.527	3
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [extracellular exosome] (R-HSA-8950304) HNRNPA2B1 [nucleoplasm] (R-HSA-71929)	0.499	2

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