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HNRNPM [nucleoplasm]
Stable Identifier
R-HSA-71949
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP M, ROM_HUMAN, Heterogeneous nuclear ribonucleoprotein M
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of pre-mRNPs (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by FGFR (Homo sapiens)
Signaling by FGFR2 (Homo sapiens)
FGFR2 alternative splicing (Homo sapiens)
ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)
FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
FGFR2b-specific alternative splicing produces FGFR2b transcript (Homo sapiens)
FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
FGFR2c-specific alternative splicing produces FGFR2c transcript (Homo sapiens)
FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
HNRNPM [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52272 HNRNPM
Gene Names
HNRNPM, HNRPM, NAGR1
Chain
initiator methionine:1, chain:2-730
Reference Genes
BioGPS Gene:4670 HNRNPM
COSMIC (genes):HNRNPM HNRNPM
CTD Gene:4670 HNRNPM
dbSNP Gene:4670 HNRNPM
ENSEMBL:ENSG00000099783 HNRNPM
ENSEMBL:ENSG00000099783.12 HNRNPM
HGNC:5046 HNRNPM
KEGG Gene (Homo sapiens):4670 HNRNPM
Monarch:4670 HNRNPM
NCBI Gene:4670 HNRNPM
OMIM:160994 HNRNPM
UCSC:P52272 HNRNPM
Reference Transcript
RefSeq:NM_005968.4 HNRNPM
RefSeq:NM_031203.3 HNRNPM
Other Identifiers
11739175_a_at
1555844_PM_s_at
1555844_s_at
16857913
18671197
18671198
18671199
18671200
18671201
18671202
18671203
18671204
18671205
18671206
18671207
18671208
18671209
18671210
18671211
18671212
18671213
200072_PM_s_at
200072_s_at
37717_at
3819544
3819545
3819546
3819550
3819562
3819566
3819568
3819569
3819571
3819572
3819577
3819579
3819582
3819584
3819585
3819597
3819599
3819600
3819602
3819607
3819608
3819609
4670
7892644
7893160
7893356
7893439
7893966
7894380
7894419
7894436
7894449
7894712
7894742
7894860
7894964
7895005
7895034
7895288
7895545
7895661
7895665
7896232
7896250
8025429
A_14_P137898
A_23_P16615
A_33_P3242919
GE81583
GO:0000380
GO:0000398
GO:0003676
GO:0003723
GO:0003729
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005681
GO:0005730
GO:0006397
GO:0008380
GO:0016020
GO:0016071
GO:0016363
GO:0019904
GO:0030312
GO:0031012
GO:0042382
GO:0043226
GO:0045202
GO:0062023
GO:0070062
GO:0071013
GO:1990904
HMNXSV003007567
HMNXSV003036194
ILMN_1745385
ILMN_1805371
L03532_at
PH_hs_0024371
TC19000151.hg
g3126877_3p_s_at
Participates
as a component of
FGFR2 IIIb-specific splicing complex [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
as an input of
ESRP1 and 2 bind FGFR2 pre-mRNA to promote FGFR2b maturation and expression (Homo sapiens)
as a member of
shuttling HNRNPs [nucleoplasm] (Homo sapiens)
Inferred To
HNRNPM [nucleoplasm]
(Caenorhabditis elegans)
HNRNPM [nucleoplasm]
(Dictyostelium discoideum)
Cross References
RefSeq
NP_005959.2
,
NP_112480.2
OpenTargets
ENSG00000099783
HPA
ENSG00000099783-HNRNPM
GeneCards
P52272
Ensembl
ENSP00000325732
,
ENST00000348943
,
ENSG00000099783
,
ENST00000325495
,
ENSP00000325376
PRO
P52272
Pharos - Targets
P52272
PDB
2DGV
,
2OT8
,
2DO0
,
2DH9
Interactors (21)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P52597 HNRNPF
2
HNRNPF [plasma membrane]
(R-HSA-8950714)
HNRNPF [nucleoplasm]
(R-HSA-71937)
0.718
6
UniProt:P25791 LMO2
1
LMO2 [nucleoplasm]
(R-HSA-8956513)
0.666
4
UniProt:Q99459 CDC5L
1
CDC5L [nucleoplasm]
(R-HSA-5420887)
0.631
7
UniProt:Q92973 TNPO1
2
TNPO1 [cilium]
(R-HSA-5624896)
TNPO1 [cytosol]
(R-HSA-180743)
0.618
3
UniProt:O43660 PLRG1
1
PLRG1 [nucleoplasm]
(R-HSA-5420890)
0.613
5
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
0.564
3
UniProt:Q8WW24 TEKT4
0.556
3
UniProt:Q96PV6 LENG8
0.556
3
UniProt:P31943 HNRNPH1
1
HNRNPH1 [nucleoplasm]
(R-HSA-71941)
0.556
3
UniProt:Q8NEA9 GMCL2
0.556
3
UniProt:Q13077 TRAF1
3
TRAF1 [cytosol]
(R-HSA-5634163)
TRAF1(1-163) [cytosol]
(R-HSA-5634199)
TRAF1(164-416) [cytosol]
(R-HSA-5634204)
0.556
3
UniProt:O14964 HGS
2
HGS [cytosol]
(R-HSA-182954)
HGS [phagocytic vesicle lumen]
(R-HSA-9635660)
0.556
3
UniProt:Q99996-2 AKAP9
0.556
3
UniProt:P25800 LMO1
1
LMO1 [nucleoplasm]
(R-HSA-8956514)
0.556
3
IntAct:EBI-10178797 4005
0.556
3
UniProt:Q9BZW7 TSG10
0.556
3
UniProt:P43360 MAGA6
0.556
3
UniProt:P25791-3 LMO2
0.556
3
UniProt:Q8AZK7 EBNA5
0.499
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
UniProt:P03372 ESR1
8
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
ESR1 [nucleoplasm]
(R-HSA-446168)
ESR1 [cytosol]
(R-HSA-9020968)
0.462
2
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