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HNRNPU [nucleoplasm]
Stable Identifier
R-HSA-71953
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP U, ROU_HUMAN, Scaffold Attachment Factor A, SAF-A, Heterogenous nuclear ribonucleoprotein U, Scaffold attachment factor A
Locations in the PathwayBrowser
Expand all
Metabolism of RNA (Homo sapiens)
Processing of Capped Intron-Containing Pre-mRNA (Homo sapiens)
Formation of pre-mRNPs (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
mRNA Splicing (Homo sapiens)
mRNA Splicing - Major Pathway (Homo sapiens)
Formation of the Spliceosomal A complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal B* complex (Homo sapiens)
Spliceosomal B* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Bact complex (Homo sapiens)
Spliceosomal B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Spliceosomal Bact complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal C* complex (Homo sapiens)
Spliceosomal C complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal E complex (Homo sapiens)
Spliceosomal E complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal P complex and exon ligation (Homo sapiens)
Spliceosomal C* complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Formation of the Spliceosomal Pre-B complex (Homo sapiens)
Spliceosomal A complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Spliceosomal Pre-B complex [nucleoplasm] (Homo sapiens)
capped, methylated pre-mRNP:CBC complex [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
Spliceosomal P complex dissociates yielding the intron-containing complex (ILS) and the spliced mRNP (new) (Homo sapiens)
Spliceosomal P complex [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
spliced mRNA:EJC:CBC complex:Alternative splicing factor [nucleoplasm] (Homo sapiens)
Alternative Splicing Factors [nucleoplasm] (Homo sapiens)
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00839 HNRNPU
Gene Names
HNRNPU, C1orf199, HNRPU, SAFA, U21.1
Chain
initiator methionine:1, chain:2-825
Reference Genes
BioGPS Gene:3192 HNRNPU
COSMIC (genes):HNRNPU HNRNPU
CTD Gene:3192 HNRNPU
dbSNP Gene:3192 HNRNPU
ENSEMBL:ENSG00000153187 HNRNPU
ENSEMBL:ENSG00000153187.21 HNRNPU
HGNC:5048 HNRNPU
KEGG Gene (Homo sapiens):3192 HNRNPU
Monarch:3192 HNRNPU
NCBI Gene:3192 HNRNPU
OMIM:602869 HNRNPU
UCSC:Q00839 HNRNPU
Reference Transcript
RefSeq:XM_017001116.1 HNRNPU
RefSeq:XM_017001117.1 HNRNPU
RefSeq:NM_031844.2 HNRNPU
RefSeq:XM_017001115.1 HNRNPU
RefSeq:NM_004501.3 HNRNPU
Other Identifiers
11721999_s_at
11722000_a_at
11722001_a_at
11722002_a_at
11723663_a_at
11758860_at
11763439_s_at
11763725_a_at
16701317
16701324
1694_s_at
200593_PM_s_at
200593_s_at
200594_PM_x_at
200594_x_at
216855_PM_s_at
216855_s_at
225805_PM_at
225805_at
235603_PM_at
235603_at
236723_PM_at
236723_at
2464494
2464496
2464498
2464500
2464501
2464502
2464503
2464504
2464505
2464506
2464507
2464508
2464509
2464510
2464511
2464512
2464513
2464514
2464517
2464519
2464520
2464522
2464523
2464527
2464528
2464529
2464532
2464534
2464535
2464537
2464539
2464543
2464545
2464548
2464549
2464550
2464551
2464552
2464553
2464554
2464555
2464556
2464557
2464558
3192
3533964
3533966
3533967
38654_at
45451_at
54026_at
72766_at
7925565
A_23_P501515
A_24_P171110
A_32_P51894
GE54612
GO:0000122
GO:0000166
GO:0000228
GO:0000278
GO:0000381
GO:0000398
GO:0000775
GO:0000776
GO:0000922
GO:0000978
GO:0000993
GO:0001097
GO:0001649
GO:0002181
GO:0003677
GO:0003682
GO:0003690
GO:0003697
GO:0003714
GO:0003723
GO:0003725
GO:0003727
GO:0003730
GO:0003779
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005681
GO:0005694
GO:0005697
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0006325
GO:0006351
GO:0006355
GO:0006396
GO:0006397
GO:0007010
GO:0007018
GO:0007049
GO:0007059
GO:0007346
GO:0008092
GO:0008143
GO:0008380
GO:0009048
GO:0009986
GO:0016020
GO:0016071
GO:0016363
GO:0016607
GO:0017069
GO:0017130
GO:0030154
GO:0030496
GO:0031490
GO:0032200
GO:0032211
GO:0032839
GO:0032922
GO:0032991
GO:0033673
GO:0034046
GO:0034244
GO:0036002
GO:0036464
GO:0042802
GO:0043021
GO:0043226
GO:0043565
GO:0044877
GO:0045944
GO:0048255
GO:0048511
GO:0048856
GO:0051301
GO:0051457
GO:0055013
GO:0070034
GO:0070934
GO:0070937
GO:0071013
GO:0071385
GO:0072686
GO:0090336
GO:0090575
GO:0098577
GO:0098963
GO:0099122
GO:0106222
GO:0110165
GO:0140014
GO:0140110
GO:1900152
GO:1901673
GO:1902275
GO:1902425
GO:1902889
GO:1990023
GO:1990280
GO:1990498
GO:1990830
GO:1990837
GO:1990841
GO:1990845
GO:1990904
GO:2000373
GO:2000648
GO:2000737
GO:2000767
HMNXSV003002286
Hs.103804.2.S1_3p_a_at
Hs.223232.0.A1_3p_at
Hs.26425.0.A1_3p_at
Hs.6616.0.A1_3p_at
ILMN_1743677
ILMN_2370135
PH_hs_0031959
TC01006247.hg
TC01006391.hg
X65488_at
g13177672_3p_a_at
g4758545_3p_a_at
p33901
p743
Participates
as a component of
hnRNP proteins [nucleoplasm] (Homo sapiens)
as a member of
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
Inferred To
HNRNPU [nucleoplasm]
(Bos taurus)
HNRNPU [nucleoplasm]
(Canis familiaris)
HNRNPU [nucleoplasm]
(Gallus gallus)
HNRNPU [nucleoplasm]
(Mus musculus)
HNRNPU [nucleoplasm]
(Plasmodium falciparum)
HNRNPU [nucleoplasm]
(Rattus norvegicus)
HNRNPU [nucleoplasm]
(Sus scrofa)
Homologues of HNRNPU [nucleoplasm]
(Caenorhabditis elegans)
hrpu-1 [nucleoplasm]
(Caenorhabditis elegans)
Dmel\CG30122 [nucleoplasm]
(Drosophila melanogaster)
hnrnpu [nucleoplasm]
(Danio rerio)
hnrnpu [nucleoplasm]
(Xenopus tropicalis)
tofu-2 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_016856604.1
,
XP_016856606.1
,
NP_114032.2
,
NP_004492.2
,
XP_016856605.1
OpenTargets
ENSG00000153187
GeneCards
Q00839
HPA
ENSG00000153187-HNRNPU
Ensembl
ENST00000640218
,
ENSP00000393151
,
ENSP00000491215
,
ENST00000444376
,
ENSG00000153187
PRO
Q00839
Pharos - Targets
Q00839
Orphanet
24602
PDB
1ZRJ
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [cytosol]
(R-COV-9694300)
p-S188,206-N [cytosol]
(R-COV-9729324)
p-8S-N [cytosol]
(R-COV-9729335)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
0.643
5
UniProt:P09429 HMGB1
5
HMGB1 [secretory granule lumen]
(R-HSA-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-HSA-6803291)
HMGB1 [extracellular region]
(R-HSA-879382)
HC23,45-HMGB1 [extracellular region]
(R-HSA-6797422)
HMGB1 [nucleoplasm]
(R-HSA-266221)
0.613
3
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.577
6
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.527
2
UniProt:P42771 CDKN2A
20
p16INK4A D84G [cytosol]
(R-HSA-9632461)
p16INK4A E88* [cytosol]
(R-HSA-9632588)
p16INK4A R87P [cytosol]
(R-HSA-9632335)
p16INK4A V126D [cytosol]
(R-HSA-9631055)
p16INK4A W110* [cytosol]
(R-HSA-9632585)
p16INK4A D84H [cytosol]
(R-HSA-9632489)
p16INK4A R80* [cytosol]
(R-HSA-9632586)
p16INK4A P114L [cytosol]
(R-HSA-9630916)
p16INK4A R58* [cytosol]
(R-HSA-9632582)
p16INK4A D84N [cytosol]
(R-HSA-9632483)
p16INK4A M53I [cytosol]
(R-HSA-9630911)
p16INK4A D84Y [cytosol]
(R-HSA-9632478)
p16INK4A G101W [cytosol]
(R-HSA-9631257)
p16INK4A P81L [cytosol]
(R-HSA-9632280)
p16INK4A A20P [cytosol]
(R-HSA-9630805)
p16INK4A D84V [cytosol]
(R-HSA-9632465)
p16INK4A P81T [cytosol]
(R-HSA-9632275)
p16INK4A P81H [cytosol]
(R-HSA-9632293)
p16INK4A D84A [cytosol]
(R-HSA-9632486)
p16INK4A P81R [cytosol]
(R-HSA-9632294)
0.508
2
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
12
UniProt:P11387 TOP1
2
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
TOP1 [nucleoplasm]
(R-HSA-4641363)
0.462
3
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