Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
HNRNPU [nucleoplasm]
Stable Identifier
R-HSA-71953
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
hnRNP U, ROU_HUMAN, Scaffold Attachment Factor A, SAF-A, Heterogenous nuclear ribonucleoprotein U, Scaffold attachment factor A
Locations in the PathwayBrowser for interactor UniProt:P14866 HNRNPL
Expand all
Developmental Biology (Homo sapiens)
Adipogenesis (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation (Homo sapiens)
Transcriptional regulation of brown and beige adipocyte differentiation by EBF2 (Homo sapiens)
EBF2 binds Blnc1 lncRNA (Homo sapiens)
HNRNPU [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00839 HNRNPU
Gene Names
HNRNPU, C1orf199, HNRPU, SAFA, U21.1
Chain
initiator methionine:, chain:2-825
Reference Genes
BioGPS Gene:3192 HNRNPU
COSMIC (genes):HNRNPU HNRNPU
CTD Gene:3192 HNRNPU
dbSNP Gene:3192 HNRNPU
ENSEMBL:ENSG00000153187 HNRNPU
HGNC:5048 HNRNPU
KEGG:hsa:3192 HNRNPU
Monarch:3192 HNRNPU
NCBI Gene:3192 HNRNPU
OMIM:602869 HNRNPU
UCSC:Q00839 HNRNPU
Reference Transcript
RefSeq:XM_017001117.1 HNRNPU
RefSeq:NM_004501.3 HNRNPU
RefSeq:XM_017001116.1 HNRNPU
RefSeq:XM_017001115.1 HNRNPU
RefSeq:NM_031844.2 HNRNPU
Other Identifiers
11721999_s_at
11722000_a_at
11722001_a_at
11722002_a_at
11723663_a_at
11744381_s_at
11757197_s_at
11758860_at
11763439_s_at
11763725_a_at
16701317
16701324
1694_s_at
200593_PM_s_at
200593_s_at
200594_PM_x_at
200594_x_at
216855_PM_s_at
216855_s_at
225786_PM_at
225786_at
225805_PM_at
225805_at
235603_PM_at
235603_at
236723_PM_at
236723_at
2464479
2464480
2464482
2464483
2464485
2464486
2464488
2464490
2464492
2464494
2464496
2464498
2464500
2464501
2464502
2464503
2464504
2464505
2464506
2464507
2464508
2464509
2464510
2464511
2464512
2464513
2464514
2464515
2464516
2464517
2464518
2464519
2464520
2464521
2464522
2464523
2464524
2464525
2464526
2464527
2464528
2464529
2464530
2464531
2464532
2464533
2464534
2464535
2464536
2464537
2464538
2464539
2464540
2464541
2464542
2464543
2464544
2464545
2464546
2464547
2464548
2464549
2464550
2464551
2464552
2464553
2464554
2464555
2464556
2464557
2464558
3192
3533964
3533966
3533967
38654_at
45451_at
54026_at
63438_at
64068_at
72766_at
7925561
7925565
91699_at
A_23_P160862
A_23_P501515
A_24_P171110
A_32_P51894
A_33_P3380161
A_33_P3416483
GE54612
GE736321
GE84044
GO:0000122
GO:0000228
GO:0000381
GO:0000398
GO:0000775
GO:0000776
GO:0000922
GO:0000978
GO:0000993
GO:0001097
GO:0001649
GO:0003677
GO:0003682
GO:0003690
GO:0003697
GO:0003714
GO:0003723
GO:0003725
GO:0003727
GO:0003730
GO:0003779
GO:0005515
GO:0005524
GO:0005634
GO:0005654
GO:0005681
GO:0005694
GO:0005697
GO:0005737
GO:0005813
GO:0005815
GO:0005819
GO:0005829
GO:0005856
GO:0006325
GO:0006355
GO:0006396
GO:0006397
GO:0007018
GO:0007346
GO:0008092
GO:0008143
GO:0008380
GO:0009048
GO:0009986
GO:0016020
GO:0016071
GO:0016363
GO:0016607
GO:0017069
GO:0017130
GO:0030154
GO:0030496
GO:0031047
GO:0031048
GO:0031490
GO:0032211
GO:0032839
GO:0032922
GO:0032991
GO:0033673
GO:0034046
GO:0034244
GO:0034584
GO:0036002
GO:0036464
GO:0042802
GO:0043021
GO:0043226
GO:0043565
GO:0044877
GO:0045944
GO:0048255
GO:0048511
GO:0048856
GO:0051301
GO:0051457
GO:0055013
GO:0060090
GO:0060816
GO:0070034
GO:0070934
GO:0070937
GO:0071013
GO:0071385
GO:0072686
GO:0090336
GO:0090575
GO:0098577
GO:0098963
GO:0099122
GO:0106222
GO:0140110
GO:1900152
GO:1901673
GO:1902275
GO:1902425
GO:1902889
GO:1990023
GO:1990280
GO:1990498
GO:1990830
GO:1990837
GO:1990841
GO:1990845
GO:1990904
GO:2000373
GO:2000648
GO:2000737
GO:2000767
HMNXSV003002286
HMNXSV003013709
Hs.103804.2.S1_3p_a_at
Hs.223232.0.A1_3p_at
Hs.26425.0.A1_3p_at
Hs.279934.1.S1_3p_at
Hs.279934.1.S1_3p_x_at
Hs.6616.0.A1_3p_at
ILMN_1743677
ILMN_2370135
PH_hs_0027918
PH_hs_0031959
PH_hs_0039508
TC01006247.hg
TC01006390.hg
TC01006391.hg
X65488_at
g13177672_3p_a_at
g4758545_3p_a_at
p33901
p741
p742
p743
Participates
as an input of
EBF2 binds Blnc1 lncRNA (Homo sapiens)
as a component of
EBF2:Blnc1 lncRNA:HNRNPU [nucleoplasm] (Homo sapiens)
hnRNP proteins [nucleoplasm] (Homo sapiens)
as a member of
nonshuttling HNRNPs [nucleoplasm] (Homo sapiens)
Inferred To
HNRNPU [nucleoplasm]
(Bos taurus)
HNRNPU [nucleoplasm]
(Canis familiaris)
HNRNPU [nucleoplasm]
(Gallus gallus)
HNRNPU [nucleoplasm]
(Mus musculus)
HNRNPU [nucleoplasm]
(Plasmodium falciparum)
HNRNPU [nucleoplasm]
(Rattus norvegicus)
HNRNPU [nucleoplasm]
(Sus scrofa)
Homologues of HNRNPU [nucleoplasm]
(Caenorhabditis elegans)
hrpu-1 [nucleoplasm]
(Caenorhabditis elegans)
Dmel\CG30122 [nucleoplasm]
(Drosophila melanogaster)
hnrnpu [nucleoplasm]
(Xenopus tropicalis)
tofu-2 [nucleoplasm]
(Caenorhabditis elegans)
Cross References
RefSeq
XP_016856604.1
,
XP_016856605.1
,
XP_016856606.1
,
NP_004492.2
,
NP_114032.2
OpenTargets
ENSG00000153187
ENSEMBL
ENSP00000491215
,
ENST00000444376
,
ENSP00000393151
,
ENST00000640218
HPA
ENSG00000153187-HNRNPU
PRO
Q00839
Pharos - Targets
Q00839
GlyGen
Q00839
Orphanet
HNRNPU
Interactors (51)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q14103 HNRNPD
1
HNRNPD [nucleoplasm]
(R-HSA-71935)
0.752
5
UniProt:Q9NZI8 IGF2BP1
1
IGF2BP1 [cytosol]
(R-HSA-428366)
0.677
7
UniProt:P0DTC9 N
13
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729340)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-COV-9729341)
ADPr-p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729275)
p-11S,2T-metR95,177-N [cytosol]
(R-COV-9729308)
p-11S,2T-N [cytosol]
(R-COV-9729264)
p-8S,2T-N [cytosol]
(R-COV-9729277)
p-8S-N [cytosol]
(R-COV-9729335)
p-S188,206-N [cytosol]
(R-COV-9729324)
N [cytosol]
(R-COV-9694300)
SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol]
(R-COV-9756489)
N [plasma membrane]
(R-COV-9694356)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus]
(R-COV-9729339)
SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane]
(R-COV-9729325)
0.643
5
UniProt:Q08211 DHX9
3
DHX9 [nucleoplasm]
(R-HSA-53517)
DHX9 [cytosol]
(R-HSA-847700)
p-DHX9 [cytosol]
(R-HSA-9836168)
0.643
3
UniProt:Q9NR30 DDX21
1
DDX21 [nucleoplasm]
(R-HSA-5250652)
0.615
3
UniProt:P09429 HMGB1
5
HC23,45-HMGB1 [extracellular region]
(R-HSA-6797422)
HMGB1 [nucleoplasm]
(R-HSA-266221)
HMGB1 [extracellular region]
(R-HSA-879382)
HMGB1 [secretory granule lumen]
(R-HSA-6803337)
HMGB1 [ficolin-1-rich granule lumen]
(R-HSA-6803291)
0.613
3
UniProt:Q8IUH3 RBM45
0.597
3
UniProt:P11387 TOP1
2
TOP1 [nucleoplasm]
(R-HSA-4641363)
monoSUMO1-K117-TOP1 [nucleoplasm]
(R-HSA-4641364)
0.597
4
UniProt:Q8TDN6 BRX1
0.564
2
UniProt:P09012 SNRPA
1
SNRPA [nucleoplasm]
(R-HSA-71915)
0.564
2
UniProt:O60506 HNRPQ
0.547
2
UniProt:Q92804 TAF15
1
TAF15 [nucleoplasm]
(R-HSA-9020680)
0.536
2
UniProt:Q9Y291 MRPS33
1
MRPS33 [mitochondrial inner membrane]
(R-HSA-5368228)
0.527
2
UniProt:P82673 MRPS35
1
MRPS35 [mitochondrial inner membrane]
(R-HSA-5368185)
0.527
2
UniProt:P52292 KPNA2
2
KPNA2 [cytosol]
(R-HSA-205976)
KPNA2 [nucleoplasm]
(R-HSA-206045)
0.527
3
UniProt:Q99873 PRMT1
2
PRMT1 [nucleoplasm]
(R-HSA-3215140)
PRMT1 [cytosol]
(R-HSA-9632173)
0.527
2
UniProt:P10636-8 MAPT
3
MAPT-8 [cytosol]
(R-HSA-9619519)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
0.527
5
UniProt:O14979 HNRNPDL
1
HNRNPDL [cytosol]
(R-HSA-8950323)
0.527
2
UniProt:P62249 RPS16
2
RPS16 [cytosol]
(R-HSA-72337)
RPS16 [nucleoplasm]
(R-HSA-6791196)
0.527
2
UniProt:Q12906 ILF3
3
ILF3 [nucleoplasm]
(R-HSA-9760401)
ILF3 [cytosol]
(R-HSA-450564)
p-T188,T315-ILF3 [cytosol]
(R-HSA-9836381)
0.527
2
UniProt:Q13573 SNW1
1
SNW1 [nucleoplasm]
(R-HSA-351663)
0.527
2
UniProt:Q14974 KPNB1
5
KPNB1 [cytosol]
(R-HSA-180733)
KPNB1 [nucleoplasm]
(R-HSA-180714)
KPNB1 [specific granule lumen]
(R-HSA-6799646)
KPNB1 [extracellular region]
(R-HSA-6806306)
KPNB1 [ficolin-1-rich granule lumen]
(R-HSA-6800978)
0.527
3
UniProt:P67809 YBX1
5
p-S32,S36-YBX1 [nucleoplasm]
(R-HSA-9733227)
p-S32,S36-YBX1 [cytosol]
(R-HSA-9736837)
YBX1 [cytosol]
(R-HSA-9736840)
YBX1 [nucleoplasm]
(R-HSA-72041)
YBX1 [extracellular region]
(R-HSA-9017791)
0.527
2
UniProt:Q9Y399 MRPS2
2
MRPS2 [mitochondrial inner membrane]
(R-HSA-8866677)
MRPS2 [mitochondrial matrix]
(R-HSA-9839682)
0.527
2
UniProt:P51398 DAP3
1
DAP3 [mitochondrial inner membrane]
(R-HSA-5368174)
0.527
2
UniProt:O95793 STAU1
0.527
2
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.527
5
UniProt:P82663 MRPS25
1
MRPS25 [mitochondrial inner membrane]
(R-HSA-5368204)
0.527
2
UniProt:Q96GA3 LTV1
2
LTV1 [cytosol]
(R-HSA-6791520)
LTV1 [nucleoplasm]
(R-HSA-6791566)
0.527
2
UniProt:Q92552 MRPS27
1
MRPS27 [mitochondrial inner membrane]
(R-HSA-5368214)
0.527
2
UniProt:P22626 HNRNPA2B1
2
HNRNPA2B1 [nucleoplasm]
(R-HSA-71929)
HNRNPA2B1 [extracellular exosome]
(R-HSA-8950304)
0.527
2
UniProt:Q5JTH9 RRP12
0.527
2
UniProt:P82933 MRPS9
1
MRPS9 [mitochondrial inner membrane]
(R-HSA-5368194)
0.527
2
UniProt:Q14684 RRP1B
0.527
2
UniProt:Q8N5N7 MRPL50
1
MRPL50 [mitochondrial inner membrane]
(R-HSA-5368181)
0.527
2
UniProt:Q9Y3I0 RTCB
1
RTCB [nucleoplasm]
(R-HSA-5696792)
0.527
2
UniProt:P49790 NUP153
1
NUP153 [nucleoplasm]
(R-HSA-157695)
0.527
2
UniProt:Q2NL82 TSR1
2
TSR1 [nucleoplasm]
(R-HSA-6791574)
TSR1 [cytosol]
(R-HSA-6791570)
0.527
2
UniProt:Q15020 SART3
0.527
2
UniProt:P62841 RPS15
2
RPS15 [cytosol]
(R-HSA-72335)
RPS15 [nucleoplasm]
(R-HSA-6798706)
0.527
2
UniProt:Q96PV0 SYNGAP1
1
SYNGAP1 [cytosol]
(R-HSA-5658217)
0.527
2
UniProt:Q13151 HNRNPA0
1
HNRNPA0 [nucleoplasm]
(R-HSA-71925)
0.527
2
UniProt:O43390 HNRNPR
1
HNRNPR [nucleoplasm]
(R-HSA-71951)
0.527
2
UniProt:O95900 TRUB2
0.527
2
UniProt:P14866 HNRNPL
1
HNRNPL [nucleoplasm]
(R-HSA-71947)
0.527
2
UniProt:P33469 NCAP
0.527
3
UniProt:Q9UHD9 UBQLN2
1
UBQLN2 [cytosol]
(R-HSA-8866007)
0.508
3
UniProt:P42771 CDKN2A
20
p16INK4A D84G [cytosol]
(R-HSA-9632461)
p16INK4A E88* [cytosol]
(R-HSA-9632588)
p16INK4A R87P [cytosol]
(R-HSA-9632335)
p16INK4A V126D [cytosol]
(R-HSA-9631055)
p16INK4A W110* [cytosol]
(R-HSA-9632585)
p16INK4A D84H [cytosol]
(R-HSA-9632489)
p16INK4A R80* [cytosol]
(R-HSA-9632586)
p16INK4A P114L [cytosol]
(R-HSA-9630916)
p16INK4A R58* [cytosol]
(R-HSA-9632582)
p16INK4A D84N [cytosol]
(R-HSA-9632483)
p16INK4A M53I [cytosol]
(R-HSA-9630911)
p16INK4A D84Y [cytosol]
(R-HSA-9632478)
p16INK4A G101W [cytosol]
(R-HSA-9631257)
p16INK4A P81L [cytosol]
(R-HSA-9632280)
p16INK4A A20P [cytosol]
(R-HSA-9630805)
p16INK4A D84V [cytosol]
(R-HSA-9632465)
p16INK4A P81T [cytosol]
(R-HSA-9632275)
p16INK4A P81H [cytosol]
(R-HSA-9632293)
p16INK4A D84A [cytosol]
(R-HSA-9632486)
p16INK4A P81R [cytosol]
(R-HSA-9632294)
0.508
2
UniProt:P13569 CFTR
17
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR [endosome membrane]
(R-HSA-6782965)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [lysosomal membrane]
(R-HSA-5627279)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
0.483
12
UniProt:P26196 DDX6
1
DDX6 [cytosol]
(R-HSA-430032)
0.483
2
IntAct:EBI-6857440 NS3
0.462
2
© 2025
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text
