Reactome | SNRPA1 [nucleoplasm]

SNRPA1 [nucleoplasm]

Stable Identifier

R-HSA-71958

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U2 A' protein, RU2A_HUMAN, U2 small nuclear ribonucleoprotein A', U2 snRNP-A'

Locations in the PathwayBrowser for interactor UniProt:Q96GM8 TOE1

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-12 family signaling (Homo sapiens)
      - Interleukin-12 signaling (Homo sapiens)
        
        Gene and protein expression by JAK-STAT signaling after Interleukin-12 stimulation (Homo sapiens)
        
        Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)
        
        SNRPA1 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:P09661 SNRPA1

Gene Names

SNRPA1

Chain

initiator methionine:, chain:2-255

Reference Genes

BioGPS Gene:6627 SNRPA1

COSMIC (genes):SNRPA1 SNRPA1

CTD Gene:6627 SNRPA1

dbSNP Gene:6627 SNRPA1

ENSEMBL:ENSG00000131876 SNRPA1

ENSEMBL_homo_sapiens_GENE:ENSG00000131876.18 SNRPA1

HGNC:11152 SNRPA1

KEGG Gene (Homo sapiens):6627 SNRPA1

Monarch:6627 SNRPA1

NCBI Gene:6627 SNRPA1

OMIM:603521 SNRPA1

UCSC:P09661 SNRPA1

Reference Transcript

RefSeq:NM_003090.3 SNRPA1

Other Identifiers

11720945_x_at

11755612_s_at

206055_PM_s_at

206055_s_at

215722_PM_s_at

215722_s_at

216977_PM_x_at

216977_x_at

2501659

2501660

2501661

2501663

3642163

3642164

3642168

3642169

3642171

3642175

3642178

3642180

3642185

3642188

3642192

3642193

37585_at

3966224

6627

74683_at

8180357

GE59711

GO:0000398

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005684

GO:0005686

GO:0006397

GO:0007283

GO:0008380

GO:0016071

GO:0016604

GO:0016607

GO:0022414

GO:0030532

GO:0030620

GO:0043226

GO:0065003

GO:0071005

GO:0071007

GO:0071013

GO:1903241

GO:1990904

HMNXSV003046596

Hs.80506.2.S1_3p_a_at

ILMN_1715179

TC15002007.hg

X13482_at

g4507120_3p_a_at

Participates

as an output of

Expression U2 small nuclear ribonucleoprotein A' (Homo sapiens)

as a component of

Inferred To

snrpA1 [nucleoplasm] (Dictyostelium discoideum)

mog-2 [nucleoplasm] (Caenorhabditis elegans)

Ghost homologue of SNRPA1 [nucleoplasm] (Danio rerio)

Ghost homologue of SNRPA1 [nucleoplasm] (Plasmodium falciparum)

Ghost homologue of SNRPA1 [nucleoplasm] (Xenopus tropicalis)

lea1 [nucleoplasm] (Schizosaccharomyces pombe)

U2A [nucleoplasm] (Drosophila melanogaster)

SNRPA1 [nucleoplasm] (Bos taurus)

SNRPA1 [nucleoplasm] (Canis familiaris)

SNRPA1 [nucleoplasm] (Gallus gallus)

SNRPA1 [nucleoplasm] (Sus scrofa)

Snrpa1 [nucleoplasm] (Mus musculus)

Snrpa1 [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_003081.2

OpenTargets

ENSG00000131876

HPA

ENSG00000131876-SNRPA1

GeneCards

P09661

Ensembl

ENSP00000254193, ENSG00000131876, ENST00000254193

PRO

P09661

Pharos - Targets

P09661

PDB

7ABI, 7W59, 5Z56, 6AHD, 5YZG, 7EVO, 5O9Z, 5XJC, 6QDV, 8C6J, 6Y5Q, 6ID0, 6ICZ, 5Z57, 6FF7, 5MQF, 7VPX, 6QX9, 5Z58, 1A9N, 7W5B, 8HK1, 7W5A, 6ID1, 7ABG, 8CH6, 6Y53, 7A5P, 8QO9, 6AH0

Interactors (51)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P08579 SNRPB2	1	SNRPB2 [nucleoplasm] (R-HSA-71960)	0.833	9
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.831	10
UniProt:Q15428 SF3A2	1	SF3A2 [nucleoplasm] (R-HSA-71964)	0.744	6
UniProt:P62306 SNRPF	2	SNRPF [nucleoplasm] (R-HSA-71907) SNRPF [cytosol] (R-HSA-191852)	0.738	5
UniProt:Q9HCS7 XAB2	1	XAB2 [nucleoplasm] (R-HSA-67411)	0.688	5
UniProt:O60306 AQR	1	AQR [nucleoplasm] (R-HSA-6781960)	0.648	5
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.643	5
UniProt:Q9BWJ5 SF3B5	1	SF3B5 [nucleoplasm] (R-HSA-71979)	0.643	3
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.643	5
UniProt:Q15459 SF3A1	1	SF3A1 [nucleoplasm] (R-HSA-71962)	0.643	5
UniProt:Q15393 SF3B3	1	SF3B3 [nucleoplasm] (R-HSA-71973)	0.643	5
UniProt:P62316 SNRPD2	2	SNRPD2 [nucleoplasm] (R-HSA-71901) SNRPD2 [cytosol] (R-HSA-191810)	0.643	5
UniProt:Q12874 SF3A3	1	SF3A3 [nucleoplasm] (R-HSA-71966)	0.643	5
UniProt:Q9ULR0 ISY1	1	ISY1 [nucleoplasm] (R-HSA-6781963)	0.59	4
UniProt:Q8N5A5-2 ZGPAT			0.556	3
UniProt:Q13422-7 IKZF1			0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q8TEQ6 GEMIN5	2	GEMIN5 [cytosol] (R-HSA-191833) GEMIN5 [nucleoplasm] (R-HSA-191765)	0.527	4
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	4
UniProt:Q659A1 ICE2	1	ICE2 [nucleoplasm] (R-HSA-6807421)	0.527	4
UniProt:Q96I25 RBM17	1	RBM17 [nucleoplasm] (R-HSA-8865891)	0.527	2
UniProt:Q9Y2F5 ICE1	1	ICE1 [nucleoplasm] (R-HSA-6807433)	0.527	2
UniProt:Q99459 CDC5L	1	CDC5L [nucleoplasm] (R-HSA-5420887)	0.527	2
UniProt:Q96DF8 ESS2			0.527	4
UniProt:Q9BWU0 NADAP			0.527	4
UniProt:O95926 SYF2	1	SYF2 [nucleoplasm] (R-HSA-8867884)	0.527	2
UniProt:Q7RTV0 PHF5A	1	PHF5A [nucleoplasm] (R-HSA-66652)	0.527	3
UniProt:Q8N954 GPT11			0.527	4
UniProt:Q96RS0 TGS1	2	TGS1 [cytosol] (R-HSA-192209) TGS1 [nucleoplasm] (R-HSA-400176)	0.527	4
UniProt:Q96GM8 TOE1			0.527	4
UniProt:Q9Y3B4 SF3B6	1	SF3B6 [nucleoplasm] (R-HSA-83808)	0.527	2
UniProt:O15042 U2SURP	1	U2SURP [nucleoplasm] (R-HSA-8865950)	0.527	2
UniProt:P63162 SNRPN	1	Me2-R108,R112-SNRPN [nucleoplasm] (R-HSA-8865931)	0.527	4
UniProt:P55199 ELL	1	ELL [nucleoplasm] (R-HSA-54257)	0.527	2
UniProt:Q15427 SF3B4	1	SF3B4 [nucleoplasm] (R-HSA-71975)	0.527	4
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	2
UniProt:P14678 SNRPB	4	SNRPB [nucleoplasm] (R-HSA-71896) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [cytosol] (R-HSA-191798) 2xMe-SNRPB [cytosol] (R-HSA-192218)	0.527	4
UniProt:P62304 SNRPE	2	SNRPE [nucleoplasm] (R-HSA-71905) SNRPE [cytosol] (R-HSA-191782)	0.527	4
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.527	4
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.527	2
UniProt:Q9H875 PRKRIP1	1	PRKRIP1 [nucleoplasm] (R-HSA-9769594)	0.527	3
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [cytosol] (R-HSA-192217)	0.527	4
UniProt:P62318 SNRPD3	3	SNRPD3 [nucleoplasm] (R-HSA-71903) 2xMe-SNRPD3 [nucleoplasm] (R-HSA-192219) 2xMe-SNRPD3 [cytosol] (R-HSA-191781)	0.527	3
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P16383 GCFC2	1	GCFC2 [nucleoplasm] (R-HSA-8869311)	0.527	4
UniProt:O43719 HTATSF1	1	HTATSF1 [nucleoplasm] (R-HSA-9770246)	0.527	4
UniProt:Q8WUD4 CCDC12	1	CCDC12 [nucleoplasm] (R-HSA-9769561)	0.527	4
UniProt:Q9H814 PHAX	2	PHAX [cytosol] (R-HSA-191804) PHAX [nucleoplasm] (R-HSA-191803)	0.527	4
UniProt:O95149 SNUPN	1	SNUPN [cytosol] (R-HSA-191857)	0.527	4
UniProt:O60508 CDC40	1	CDC40 [nucleoplasm] (R-HSA-72062)	0.527	4
UniProt:P11387 TOP1	2	monoSUMO1-K117-TOP1 [nucleoplasm] (R-HSA-4641364) TOP1 [nucleoplasm] (R-HSA-4641363)	0.462	2

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