Reactome | SF3B4 [nucleoplasm]

SF3B4 [nucleoplasm]

Stable Identifier

R-HSA-71975

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

SAP49, Splicing factor 3B subunit 4 (Spliceosome associated protein 49) (SAP 49) (SF3b50) (Pre-mRNA splicing factor SF3b 49 kDa subunit), Splicing factor 3B subunit 4, Spliceosome associated protein 49, SAP 49, SF3b50, Pre-mRNA splicing factor SF3b 49 kDa subunit

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q15427 SF3B4

Gene Names

SF3B4, SAP49

Chain

initiator methionine:, chain:2-424

Reference Genes

BioGPS Gene:10262 SF3B4

COSMIC (genes):SF3B4 SF3B4

CTD Gene:10262 SF3B4

dbSNP Gene:10262 SF3B4

ENSEMBL:ENSG00000143368 SF3B4

HGNC:10771 SF3B4

KEGG:hsa:10262 SF3B4

Monarch:10262 SF3B4

NCBI Gene:10262 SF3B4

OMIM:605593 SF3B4

UCSC:Q15427 SF3B4

Reference Transcript

RefSeq:NM_005850.4 SF3B4

Other Identifiers

10262

11724493_s_at

11724494_x_at

11744950_s_at

16692656

209044_PM_x_at

209044_x_at

2434160

2434161

2434162

2434163

2434164

2434165

2434166

2434167

2434169

2434170

2434171

33909_at

3541040

3541043

3541048

7919659

A_23_P35131

GE61193

GO:0000375

GO:0000398

GO:0003676

GO:0003723

GO:0005515

GO:0005634

GO:0005654

GO:0005681

GO:0005684

GO:0005686

GO:0005689

GO:0006397

GO:0008380

GO:0016071

GO:0043226

GO:0048026

GO:0065003

GO:0071005

GO:1903241

GO:1990935

HMNXSV003044244

ILMN_1722648

PH_hs_0030054

TC01003196.hg

g13279088_3p_at

g13279088_3p_x_at

Participates

as a component of

SF3B [nucleoplasm] (Homo sapiens)

Inferred To

sap-49 [nucleoplasm] (Caenorhabditis elegans)

Sf3b4 [nucleoplasm] (Mus musculus)

Sf3b4 [nucleoplasm] (Rattus norvegicus)

sap49 [nucleoplasm] (Schizosaccharomyces pombe)

sf3b4 [nucleoplasm] (Danio rerio)

sf3b4 [nucleoplasm] (Dictyostelium discoideum)

sf3b4 [nucleoplasm] (Xenopus tropicalis)

Spx [nucleoplasm] (Drosophila melanogaster)

SF3B4 [nucleoplasm] (Bos taurus)

SF3B4 [nucleoplasm] (Canis familiaris)

SF3B4 [nucleoplasm] (Gallus gallus)

SF3B4 [nucleoplasm] (Plasmodium falciparum)

SF3B4 [nucleoplasm] (Sus scrofa)

Cross References

RefSeq

NP_005841.1

OpenTargets

ENSG00000143368

ENSEMBL

ENSP00000271628, ENST00000271628

HPA

ENSG00000143368-SF3B4

PRO

Q15427

Pharos - Targets

Q15427

Orphanet

SF3B4

GlyGen

Q15427

PDB

5Z58, 7DVQ, 8QO9, 6Y53, 7ABI, 7ABH, 7ONB, 8CH6, 7QTT, 6AH0, 5GVQ, 8Y7E, 7EVO, 6AHD, 5Z56, 5Z57, 7VPX, 7ABG, 8HK1, 6QX9, 6Y5Q, 1X5T

Interactors (18)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O43639 NCK2	1	NCK2 [cytosol] (R-HSA-204885)	0.781	7
UniProt:Q2TBE0 CWF19L2	1	CWF19L2 [nucleoplasm] (R-HSA-9770846)	0.718	6
UniProt:P42685 FRK	4	p-Y387-FRK [cytosol] (R-HSA-8847965) FRK [specific granule lumen] (R-HSA-6801037) FRK [extracellular region] (R-HSA-6806235) FRK [azurophil granule lumen] (R-HSA-6799142)	0.666	4
UniProt:Q14498 RBM39	1	RBM39 [nucleoplasm] (R-HSA-9770254)	0.666	4
UniProt:P62993 GRB2	1	GRB2 [cytosol] (R-HSA-8983328)	0.665	3
UniProt:P62306 SNRPF	2	SNRPF [cytosol] (R-HSA-191852) SNRPF [nucleoplasm] (R-HSA-71907)	0.643	4
UniProt:Q9UQB8 BAIAP2	1	BAIAP2 [cytosol] (R-HSA-442574)	0.556	3
UniProt:P47897 QARS1	2	QARS [cytosol] (R-HSA-379615) QARS [mitochondrial matrix] (R-HSA-379592)	0.556	3
UniProt:P20081	1	FPR1 [cytosol] (R-SCE-2026007)	0.556	3
UniProt:P00519 ABL1	6	p-S456-ABL1 [nucleoplasm] (R-HSA-5686576) ABL1 [nucleoplasm] (R-HSA-5686579) p-Y226,Y393-ABL1 [cytosol] (R-HSA-8942610) ABL1 [cytosol] (R-HSA-375987) p-Y226,Y393-ABL1 [nucleoplasm] (R-HSA-8985251) p-Y393-ABL1 [cytosol] (R-HSA-9865161)	0.536	2
UniProt:P14678 SNRPB	4	2xMe-SNRPB [cytosol] (R-HSA-192218) SNRPB [cytosol] (R-HSA-191798) Me2-R108,R112-SNRPB [nucleoplasm] (R-HSA-192213) SNRPB [nucleoplasm] (R-HSA-71896)	0.527	3
UniProt:P09661 SNRPA1	1	SNRPA1 [nucleoplasm] (R-HSA-71958)	0.527	4
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.527	4
UniProt:O43143 DHX15	1	DHX15 [nucleoplasm] (R-HSA-5688097)	0.527	2
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.519	2
UniProt:O75533 SF3B1	1	SF3B1 [nucleoplasm] (R-HSA-71968)	0.483	3
UniProt:O60563 CCNT1	1	CCNT1 [nucleoplasm] (R-HSA-51611)	0.483	2
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.483	2