Reactome | U2AF2 [nucleoplasm]

U2AF2 [nucleoplasm]

Stable Identifier

R-HSA-71987

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

U2AF 65 kDa subunit, Splicing factor U2AF 65 kDa subunit, U2 auxiliary factor 65 kDa subunit, U2 snRNP auxiliary factor large subunit, hU2AF(65)

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P26368 U2AF2

Gene Names

U2AF2, U2AF65

Chain

initiator methionine:, chain:2-475

Reference Genes

BioGPS Gene:11338 U2AF2

COSMIC (genes):U2AF2 U2AF2

CTD Gene:11338 U2AF2

dbSNP Gene:11338 U2AF2

ENSEMBL:ENSG00000063244 U2AF2

HGNC:23156 U2AF2

KEGG:hsa:11338 U2AF2

Monarch:11338 U2AF2

NCBI Gene:11338 U2AF2

OMIM:191318 U2AF2

UCSC:P26368 U2AF2

Reference Transcript

Participates

as an input of

JMJD6 dimer hydroxylates lysine residues of U2AF2 (Homo sapiens)

as a component of

as an output of

Docking of the TAP:EJC Complex with the NPC (Homo sapiens)

Other forms of this molecule

5OHK15,276-U2AF2 [nucleoplasm]

Inferred To

Ghost homologue of U2AF2 [nucleoplasm] (Danio rerio)

U2af50 [nucleoplasm] (Drosophila melanogaster)

U2AF2 [nucleoplasm] (Bos taurus)

U2AF2 [nucleoplasm] (Canis familiaris)

U2AF2 [nucleoplasm] (Gallus gallus)

U2AF2 [nucleoplasm] (Plasmodium falciparum)

U2AF2 [nucleoplasm] (Sus scrofa)

u2af2 [nucleoplasm] (Dictyostelium discoideum)

u2af2 [nucleoplasm] (Xenopus tropicalis)

uaf-1 [nucleoplasm] (Caenorhabditis elegans)

MUD2 [nucleoplasm] (Saccharomyces cerevisiae)

prp2 [nucleoplasm] (Schizosaccharomyces pombe)

U2af2 [nucleoplasm] (Mus musculus)

U2af2 [nucleoplasm] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000063244

ENSEMBL

ENSP00000388475, ENST00000308924, ENST00000450554, ENSP00000307863, ENSG00000063244

GeneCards

U2AF2

HPA

ENSG00000063244-U2AF2

PRO

P26368

Pharos - Targets

P26368

GlyGen

P26368

PDB

7SN6, 4TU9, 3VAK, 7S3C, 2U2F, 4TU8, 3VAJ, 6TR0, 3VAL, 6XLW, 6XLV, 3VAH, 3VAG, 1JMT, 4TU7, 7S3A, 1OPI, 2M0G, 7S3B, 3VAI, 2G4B, 3VAF, 1U2F, 1O0P, 5W0G, 9C7A, 5EV2, 8P25, 5EV3, 9C7B, 4FXW, 5W0H, 5EV4, 2YH0, 3VAM, 2HZC, 5EV1, 6XLX, 2YH1

Interactors (46)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15637 SF1	1	SF1 [nucleoplasm] (R-HSA-8865928)	0.948	23
UniProt:Q01081 U2AF1	1	U2AF1 [nucleoplasm] (R-HSA-71985)	0.948	14
UniProt:Q9UHX1 PUF60	1	PUF60 [nucleoplasm] (R-HSA-8865910)	0.849	7
UniProt:P78362 SRPK2	1	SRPK2 [cytosol] (R-HSA-9729332)	0.803	8
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.727	6
UniProt:Q8IWZ8 SUGP1	1	SUGP1 [nucleoplasm] (R-HSA-72043)	0.713	4
UniProt:O43395 PRPF3	1	PRPF3 [nucleoplasm] (R-HSA-6806806)	0.707	4
UniProt:P09012 SNRPA	1	SNRPA [nucleoplasm] (R-HSA-71915)	0.703	5
UniProt:P54253 ATX1			0.674	5
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.669	5
UniProt:Q9NVV9 THAP1			0.666	4
UniProt:Q8IX12 CCAR1	1	CCAR1 [nucleoplasm] (R-HSA-72048)	0.64	3
UniProt:Q99590 SCAFB			0.64	5
UniProt:Q07955 SRSF1	1	SRSF1 [nucleoplasm] (R-HSA-72031)	0.64	4
UniProt:P98175 RBM10	1	RBM10 [nucleoplasm] (R-HSA-9770262)	0.632	3
UniProt:P52756 RBM5	1	RBM5 [nucleoplasm] (R-HSA-72049)	0.629	3
UniProt:Q8N684 CPSF7	2	CPSF7 [cytosol] (R-HSA-9715140) CPSF7 [nucleoplasm] (R-HSA-72012)	0.618	3
UniProt:Q8IWX8 CHERP	1	CHERP [nucleoplasm] (R-HSA-8865901)	0.618	3
UniProt:Q9UKV3 ACIN1	4	ACIN1 [cytosol] (R-HSA-212519) ACIN1(1094-1341) [cytosol] (R-HSA-212516) ACIN1(1-1093) [cytosol] (R-HSA-212520) ACIN1 [nucleoplasm] (R-HSA-9770238)	0.615	5
UniProt:Q9NWB6 ARGL1			0.583	4
UniProt:Q08117 TLE5	1	AES [nucleoplasm] (R-HSA-4648963)	0.556	3
UniProt:Q9UI36-2 DACH1			0.556	3
UniProt:P62995 TRA2B	2	TRA2B [cytosol] (R-HSA-9715137) TRA2B [nucleoplasm] (R-HSA-8850859)	0.527	3
UniProt:Q09161 NCBP1	2	NCBP1 [nucleoplasm] (R-HSA-51469) NCBP1 [cytosol] (R-HSA-162459)	0.527	3
UniProt:P82933 MRPS9	1	MRPS9 [mitochondrial inner membrane] (R-HSA-5368194)	0.527	3
UniProt:Q96SB4 SRPK1	2	SRPK1 [cytosol] (R-HSA-9729349) SRPK1 [nucleoplasm] (R-HSA-9821984)	0.527	4
UniProt:P0DTC9 N	13	SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729340) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-COV-9729341) ADPr-p-11S,2T-metR95,177-N [cytosol] (R-COV-9729275) p-11S,2T-metR95,177-N [cytosol] (R-COV-9729308) p-11S,2T-N [cytosol] (R-COV-9729264) p-8S,2T-N [cytosol] (R-COV-9729277) p-8S-N [cytosol] (R-COV-9729335) p-S188,206-N [cytosol] (R-COV-9729324) N [cytosol] (R-COV-9694300) SUMO1-K62,ADPr-,p-11S,2T,met-R95,177,Ac-K375-N [cytosol] (R-COV-9756489) N [plasma membrane] (R-COV-9694356) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [nucleolus] (R-COV-9729339) SUMO1-K62-ADPr-p-11S,2T-metR95,177-N [plasma membrane] (R-COV-9729325)	0.527	2
UniProt:O14641 DVL2	5	pp-DVL2 [cytosol] (R-HSA-3772398) p-DVL2 [cytosol] (R-HSA-201706) p-DVL2 [clathrin-coated endocytic vesicle] (R-HSA-5138444) DVL2 [cytosol] (R-HSA-201694) ub-DVL2 [cytosol] (R-HSA-4652689)	0.519	2
UniProt:Q96PU8 QKI	2	QKI(1-504)-p-RAF1(278- 648) fusion [cytosol] (R-HSA-6802546) QKI(1-504)-RAF1(278-648) fusion [cytosol] (R-HSA-6802466)	0.519	2
UniProt:Q9BWF3 RBM4	1	RBM4 [cytosol] (R-HSA-8878898)	0.519	2
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.519	2
UniProt:Q7Z7F0 KHDC4			0.519	2
UniProt:Q9HCK8 CHD8	1	CHD8 [nucleoplasm] (R-HSA-3221598)	0.483	2
UniProt:Q86VM9 ZC3H18	1	ZC3H18 [nucleoplasm] (R-HSA-9930040)	0.483	3
UniProt:O43290 SART1	1	SART1 [nucleoplasm] (R-HSA-4615999)	0.483	2
UniProt:Q86XP3 DDX42	1	DDX42 [nucleoplasm] (R-HSA-8867894)	0.483	2
UniProt:O15042 U2SURP	1	U2SURP [nucleoplasm] (R-HSA-8865950)	0.483	4
UniProt:Q6P2Q9 PRPF8	1	PRPF8 [nucleoplasm] (R-HSA-83810)	0.483	2
UniProt:Q13435 SF3B2	1	SF3B2 [nucleoplasm] (R-HSA-71971)	0.483	3
UniProt:P46013 KI67			0.483	2
UniProt:Q9UKJ3 GPTC8			0.483	2
UniProt:Q9NYF8 BCLF1			0.483	3
UniProt:Q9NW64 RBM22	1	RBM22 [nucleoplasm] (R-HSA-5215975)	0.483	2
UniProt:P82979 SARNP	1	SARNP [nucleoplasm] (R-HSA-8849146)	0.471	3
UniProt:P15941 MUC1	19	GalNAc-MUC1(24-1255) [plasma membrane] (R-HSA-8858449) Core 2 (MUC1) [Golgi lumen] (R-HSA-1462167) Core 2a (MUC1) [Golgi lumen] (R-HSA-6784286) GalNAc-MUC1(24-1255) [Golgi lumen] (R-HSA-913642) Sialyl Tn antigen (MUC1) [Golgi lumen] (R-HSA-1463526) T-antigen (MUC1) [Golgi lumen] (R-HSA-1462359) Sialyl-2,3 T-antigen (MUC1) [Golgi lumen] (R-HSA-1463483) Sialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463531) Disialyl T-antigen (MUC1) [Golgi lumen] (R-HSA-1463518) MUC1(24-1255) [Golgi lumen] (R-HSA-913611) Core 6 (MUC1) [Golgi lumen] (R-HSA-1462085) extended Core 6 (MUC1) [Golgi lumen] (R-HSA-1967019) Core 7 (MUC1) [Golgi lumen] (R-HSA-1462105) Core 3 (MUC1) [Golgi lumen] (R-HSA-1462068) Core 4 (MUC1) [Golgi lumen] (R-HSA-1462154) Core 5 (MUC1) [Golgi lumen] (R-HSA-1462231) Core 2S (MUC1) [Golgi lumen] (R-HSA-6786333) Core 8 (MUC1) [Golgi lumen] (R-HSA-1462219) MUC1(24-1255) [plasma membrane] (R-HSA-6793976)	0.471	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2

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