Reactome | FUS [nucleoplasm]

FUS [nucleoplasm]

Stable Identifier

R-HSA-72040

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

FUS - RNA binding protein/TLS, RNA-binding protein FUS, Oncogene FUS, Oncogene TLS, Translocated in liposarcoma protein, POMp75, 75 kDa DNA-pairing protein

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P35637 FUS

Gene Names

FUS, TLS

Chain

chain:1-526

Reference Genes

BioGPS Gene:2521 FUS

COSMIC (genes):FUS FUS

CTD Gene:2521 FUS

dbSNP Gene:2521 FUS

ENSEMBL:ENSG00000089280 FUS

HGNC:4010 FUS

KEGG:hsa:2521 FUS

Monarch:2521 FUS

NCBI Gene:2521 FUS

OMIM:137070 FUS

UCSC:P35637 FUS

Reference Transcript

Other Identifiers

11745190_a_at

1564802_3p_at

1564802_PM_at

1564802_at

1565717_PM_s_at

1565717_s_at

16818207

200959_3p_at

200959_PM_at

200959_at

217370_3p_x_at

217370_PM_x_at

217370_x_at

231108_PM_at

231108_at

2521

3656910

3656912

3656913

3656914

3656915

3656916

3656917

3656918

3656919

3656920

3656921

3656922

3656923

3656924

3656925

3656926

3656927

3656928

3656932

3656933

3656934

3656935

3656936

3656937

3656938

3656939

3656940

3656941

3656942

3656943

3656944

3656945

3656946

3656947

3656948

3656949

3656951

3656952

3656953

3656955

3656956

3656958

3656960

3656962

3656963

39180_at

43501_at

46825_at

63941_at

73061_at

7995069

A_14_P116276

A_14_P136409

A_14_P136436

A_14_P139905

A_23_P106887

GE58786

GE646248

GE85981

GE85986

GE88499

GO:0003676

GO:0003677

GO:0003682

GO:0003712

GO:0003713

GO:0003723

GO:0003730

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006357

GO:0008380

GO:0010467

GO:0042802

GO:0043226

GO:0043232

GO:0043484

GO:0045893

GO:0046872

GO:0048255

GO:0051260

GO:0060090

GO:0065003

GO:0098978

GO:0098982

GO:0099523

GO:0099524

GO:0140110

GO:0140693

GO:0140694

GO:1905168

GO:1990000

HMNXSV003036649

HMNXSV003041499

Hs.107720.0.A1_3p_at

Hs.99969.2.S1_3p_a_at

Hs.99969.2.S1_3p_s_at

Hs.99969.2.S1_3p_x_at

Hs.99969.3.S1_3p_at

Hs2.382749.1.S1_3p_x_at

Hs2.392171.1.S1_3p_s_at

ILMN_2306066

PH_hs_0022279

PH_hs_0031515

TC16000372.hg

TC16001494.hg

TC16001495.hg

X71428_at

g4826733_3p_at

g4826733_3p_s_at

g4826733_3p_x_at

p6361

Participates

as a component of

Spliceosomal Intermediate C Complex [nucleoplasm] (Homo sapiens)

as a member of

Alternative Splicing Factors [nucleoplasm] (Homo sapiens)

Inferred To

Dmel\CG14718 [nucleoplasm] (Drosophila melanogaster)

caz [nucleoplasm] (Drosophila melanogaster)

fust-1 [nucleoplasm] (Caenorhabditis elegans)

Fus [nucleoplasm] (Mus musculus)

Fus [nucleoplasm] (Rattus norvegicus)

fus [nucleoplasm] (Xenopus tropicalis)

FUS [nucleoplasm] (Bos taurus)

FUS [nucleoplasm] (Canis familiaris)

FUS [nucleoplasm] (Gallus gallus)

FUS [nucleoplasm] (Sus scrofa)

Homologues of FUS [nucleoplasm] (Drosophila melanogaster)

Cross References

RefSeq

NP_001164105.1, NP_004951.1

OpenTargets

ENSG00000089280

ENSEMBL

ENSP00000254108, ENST00000254108, ENST00000380244, ENSP00000369594

HPA

ENSG00000089280-FUS

PRO

P35637

Pharos - Targets

P35637

GlyGen

P35637

Orphanet

FUS

PDB

5YVI, 5YVH, 5XSG, 7CYL, 6KJ3, 6KJ4, 7VQQ, 6SNJ, 6XFM, 6BZP, 5XRR, 6BXV, 6G99, 6BWZ, 5YVG, 6KJ1, 4FDD, 2LCW, 2LA6, 6GBM, 6KJ2, 5W3N, 4FQ3

Interactors (31)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q15424 SAFB	3	monoSUMO1-K231,K294-SAFB [nucleoplasm] (R-HSA-4085343) polySUMO2,3-K231,K294-SAFB [nucleoplasm] (R-HSA-4085357) SAFB [nucleoplasm] (R-HSA-4085379)	0.727	8
UniProt:P09651 HNRNPA1	2	HNRNPA1 [nucleoplasm] (R-HSA-71927) HNRNPA1 [cytosol] (R-HSA-9727902)	0.671	5
UniProt:Q99873 PRMT1	2	PRMT1 [nucleoplasm] (R-HSA-3215140) PRMT1 [cytosol] (R-HSA-9632173)	0.657	5
UniProt:Q08211 DHX9	3	DHX9 [nucleoplasm] (R-HSA-53517) DHX9 [cytosol] (R-HSA-847700) p-DHX9 [cytosol] (R-HSA-9836168)	0.63	9
UniProt:Q12906 ILF3	3	ILF3 [nucleoplasm] (R-HSA-9760401) ILF3 [cytosol] (R-HSA-450564) p-T188,T315-ILF3 [cytosol] (R-HSA-9836381)	0.615	3
UniProt:P07910 HNRNPC	3	HNRNPC [nucleoplasm] (R-HSA-71933) SUMO1-K250-HNRNPC [nucleoplasm] (R-HSA-4570543) HNRNPC [cytosol] (R-HSA-9715136)	0.615	6
UniProt:P45481 Crebbp	4	CREBBP [nucleoplasm] (R-MMU-193545) Crebbp [nucleoplasm] (R-MMU-556795) Foxo4-S-S-Crebbp [nucleoplasm] (R-MMU-9617719) monoSumo1-K999,K1034,K1057-Crebbp [nucleoplasm] (R-MMU-3927936)	0.602	4
UniProt:Q12905 ILF2	5	ILF2 [cytosol] (R-HSA-9836392) ILF2 [specific granule lumen] (R-HSA-6799611) ILF2 [extracellular region] (R-HSA-6799684) ILF2 [tertiary granule lumen] (R-HSA-6800995) ILF2 [ficolin-1-rich granule lumen] (R-HSA-6801001)	0.597	8
UniProt:Q09472 EP300	5	EP300 [nucleoplasm] (R-HSA-381325) p-S,T-EP300 [nucleoplasm] (R-HSA-8878072) FOXO4-S-S-EP300 [nucleoplasm] (R-HSA-9617691) Foxo4-S-S-EP300 [nucleoplasm] (R-HSA-9617720) monoSUMO1-K1020,1024-EP300 [nucleoplasm] (R-HSA-3899306)	0.591	4
UniProt:P23246 SFPQ	3	SFPQ [nucleoplasm] (R-HSA-3900138) p-Y-SFPQ [nucleoplasm] (R-HSA-8849461) SFPQ [cytosol] (R-HSA-9635505)	0.564	2
UniProt:P60896 SEM1	2	SEM1 [cytosol] (R-HSA-8866674) SEM1 [nucleoplasm] (R-HSA-8866665)	0.556	3
UniProt:P19793 RXRA	4	RXRA [nucleoplasm] (R-HSA-381319) monoSUMO1-K108-RXRA [nucleoplasm] (R-HSA-4341130) p-S21-RXRA [nucleoplasm] (R-HSA-5334811) RXRA [cytosol] (R-HSA-9619757)	0.556	3
UniProt:Q05586 GRIN1	3	GRIN1 [transport vesicle membrane] (R-HSA-9610565) GRIN1 [endoplasmic reticulum membrane] (R-HSA-9609763) GRIN1 [plasma membrane] (R-HSA-419564)	0.556	3
UniProt:Q13242 SRSF9	1	SRSF9 [nucleoplasm] (R-HSA-72037)	0.547	2
UniProt:P61978 HNRNPK	2	HNRNPK [nucleoplasm] (R-HSA-71945) polySUMO2-K422-HNRNPK [nucleoplasm] (R-HSA-4570532)	0.527	2
UniProt:Q6PKG0 LARP1	1	LARP1 [cytosol] (R-HSA-9760421)	0.527	3
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q9Y2W1 THRAP3	1	THRAP3 [nucleoplasm] (R-HSA-8932115)	0.527	2
UniProt:Q92841 DDX17	2	monoSUMO1-K50-DDX17 [nucleoplasm] (R-HSA-3900104) DDX17 [nucleoplasm] (R-HSA-3900090)	0.527	3
UniProt:Q13573 SNW1	1	SNW1 [nucleoplasm] (R-HSA-351663)	0.527	2
UniProt:Q00839 HNRNPU	1	HNRNPU [nucleoplasm] (R-HSA-71953)	0.527	5
UniProt:P52272 HNRNPM	1	HNRNPM [nucleoplasm] (R-HSA-71949)	0.527	4
UniProt:P62314 SNRPD1	3	2xMe-SNRPD1 [cytosol] (R-HSA-192217) SNRPD1 [cytosol] (R-HSA-191890) 2xMe-SNRPD1 [nucleoplasm] (R-HSA-192215)	0.527	2
UniProt:P17844 DDX5	4	DDX5 [nucleoplasm] (R-HSA-3900136) DDX5 [cytosol] (R-HSA-9682643) polySUMO2-K53-DDX5 [nucleoplasm] (R-HSA-3900186) monoSUMO1-K53-DDX5 [nucleoplasm] (R-HSA-3900041)	0.527	5
UniProt:P62304 SNRPE	2	SNRPE [cytosol] (R-HSA-191782) SNRPE [nucleoplasm] (R-HSA-71905)	0.527	2
UniProt:P22626 HNRNPA2B1	2	HNRNPA2B1 [nucleoplasm] (R-HSA-71929) HNRNPA2B1 [extracellular exosome] (R-HSA-8950304)	0.527	2
UniProt:Q07666 KHDRBS1	3	p-Y435,Y440,Y443-KHDRBS1 [nucleoplasm] (R-HSA-8848970) p-Y435,Y440,Y443-KHDRBS1 [cytosol] (R-HSA-8848995) KHDRBS1 [nucleoplasm] (R-HSA-8848941)	0.527	2
UniProt:Q15717 ELAVL1	6	ELAVL1 [nucleoplasm] (R-HSA-450601) p-S158,S221-ELAVL1 [nucleoplasm] (R-HSA-450576) p-S221,S318-ELAVL1 [nucleoplasm] (R-HSA-450532) ELAVL1 [cytosol] (R-HSA-450582) p-S221,S318-ELAVL1 [cytosol] (R-HSA-450448) p-S158,S221-ELAVL1 [cytosol] (R-HSA-450376)	0.527	4
UniProt:Q92993 KAT5	1	KAT5 [nucleoplasm] (R-HSA-3321979)	0.524	2
UniProt:Q15149 PLEC	3	PLEC(2396-4684) [cytosol] (R-HSA-350618) PLEC(1-2395) [cytosol] (R-HSA-350638) PLEC [cytosol] (R-HSA-201575)	0.518	4
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.462	2